(Q95407636)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22952011%20AND%20SRC:MED&resulttype=core&format=json

24 May 2020

title

Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer (English)

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24 May 2020

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2

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24 May 2020

Fabrizio Daddadifagagna

series ordinal

3

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24 May 2020

1

Gabriele Sulli

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24 May 2020

publication date

6 September 2012

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24 May 2020

published in

Nature Reviews Cancer

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24 May 2020

volume

12

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24 May 2020

issue

10

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24 May 2020

page(s)

709-720

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Chromatin Structure: A Repeating Unit of Histones and DNA

24 May 2020

cites work

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Heterochromatin structure and function

31 March 2020

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Living on a break: cellular senescence as a DNA-damage response

31 March 2020

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An oncogene-induced DNA damage model for cancer development

31 March 2020

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

31 March 2020

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

31 March 2020

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The ATR barrier to replication-born DNA damage.

31 March 2020

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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

31 March 2020

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The serial cultivation of human diploid cell strains

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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Cellular senescence: hot or what?

31 March 2020

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The DNA-damage response in human biology and disease

31 March 2020

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The power and the promise of oncogene-induced senescence markers.

31 March 2020

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

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Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

31 March 2020

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Never-ageing cellular senescence

31 March 2020

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Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains

31 March 2020

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gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

31 March 2020

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Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

31 March 2020

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Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals

31 March 2020

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Global chromatin compaction limits the strength of the DNA damage response

31 March 2020

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High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome.

31 March 2020

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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

31 March 2020

1 reference

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.

31 March 2020

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The human Mi-2/NuRD complex and gene regulation

31 March 2020

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KAP1 is associated with peritoneal carcinomatosis in gastric cancer.

31 March 2020

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Novel breast cancer metastasis-associated proteins

31 March 2020

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Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair.

31 March 2020

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Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

31 March 2020

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Positional stability of single double-strand breaks in mammalian cells

31 March 2020

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HMGA1 protein is a novel target of the ATM kinase

31 March 2020

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HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

31 March 2020

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31 March 2020

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Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair

31 March 2020

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INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.

31 March 2020

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A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

31 March 2020

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Mammalian Ino80 mediates double-strand break repair through its role in DNA end strand resection

31 March 2020

1 reference

The mammalian INO80 complex is recruited to DNA damage sites in an ARP8 dependent manner

31 March 2020

1 reference

The Ino80 chromatin-remodeling enzyme regulates replisome function and stability.

31 March 2020

1 reference

Global regulation of H2A.Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity

31 March 2020

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Non-transcriptional control of DNA replication by c-Myc

31 March 2020

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Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction

31 March 2020

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Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex

31 March 2020

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A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair

31 March 2020

1 reference

Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.

31 March 2020

1 reference

SWI/SNF nucleosome remodellers and cancer.

31 March 2020

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SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus

31 March 2020

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HP1: heterochromatin binding proteins working the genome

31 March 2020

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

31 March 2020

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

31 March 2020

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HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

31 March 2020

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ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

31 March 2020

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Heterochromatin protein 1 is recruited to various types of DNA damage.

31 March 2020

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Recruitment of heterochromatin protein 1 to DNA repair sites.

31 March 2020

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HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

31 March 2020

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Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncology

31 March 2020

1 reference

Linking Heterochromatin Protein 1 (HP1) to cancer progression

31 March 2020

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A requirement for dimerization of HP1Hsalpha in suppression of breast cancer invasion.

31 March 2020

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Heterochromatin protein 1gamma epigenetically regulates cell differentiation and exhibits potential as a therapeutic target for various types of cancers

31 March 2020

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Epigenetic alterations associated with cellular senescence: a barrier against tumorigenesis or a red carpet for cancer?

31 March 2020

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

31 March 2020

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

31 March 2020

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Genomic instability in mice lacking histone H2AX

31 March 2020

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

31 March 2020

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H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

31 March 2020

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Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

31 March 2020

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Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression

31 March 2020

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31 March 2020

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Genetic variation in H2AFX contributes to risk of non-Hodgkin lymphoma

31 March 2020

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Histone H2AX Is a Mediator of Gastrointestinal Stromal Tumor Cell Apoptosis following Treatment with Imatinib Mesylate

31 March 2020

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WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

31 March 2020

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Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

31 March 2020

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

31 March 2020

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BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair

31 March 2020

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BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

31 March 2020

1 reference

An anticlastogenic function for the Polycomb Group gene Bmi1.

31 March 2020

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Enhancing chemotherapy response with Bmi-1 silencing in ovarian cancer

31 March 2020

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DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

31 March 2020

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

31 March 2020

1 reference

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

31 March 2020

1 reference

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

31 March 2020

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Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks

31 March 2020

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

31 March 2020

1 reference

Histone ubiquitination associates with BRCA1-dependent DNA damage response

31 March 2020

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Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

31 March 2020

1 reference

Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation

31 March 2020

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Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin

31 March 2020

1 reference

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

31 March 2020

1 reference

The global histone modification pattern correlates with cancer recurrence and overall survival in gastric adenocarcinoma

31 March 2020

1 reference

Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia

31 March 2020

1 reference

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

31 March 2020

1 reference

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

31 March 2020

1 reference

Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage

31 March 2020

1 reference

Complicated tails: histone modifications and the DNA damage response

31 March 2020

1 reference

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

31 March 2020

1 reference

BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response

31 March 2020

1 reference

A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response.

31 March 2020

1 reference

Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair

31 March 2020

1 reference

The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.

31 March 2020

1 reference

Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56

31 March 2020

1 reference

Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells

31 March 2020

1 reference

Histone H3-K56 acetylation is important for genomic stability in mammals

31 March 2020

1 reference

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

31 March 2020

1 reference

CBP/p300-mediated acetylation of histone H3 on lysine 56

31 March 2020

1 reference

Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

31 March 2020

1 reference

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

31 March 2020

1 reference

Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance.

31 March 2020

1 reference

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

31 March 2020

1 reference

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

31 March 2020

1 reference

Molecular dissection of formation of senescence-associated heterochromatin foci

31 March 2020

1 reference

Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci

31 March 2020

1 reference

ATR signaling can drive cells into senescence in the absence of DNA breaks

31 March 2020

1 reference

Replication Stress Interferes with Histone Recycling and Predeposition Marking of New Histones

31 March 2020

1 reference

Chromatin assembly during SV40 DNA replication in vitro

31 March 2020

1 reference

Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway

31 March 2020

1 reference

Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability.

31 March 2020

1 reference

Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest

31 March 2020

1 reference

Mutations in deoxyribonucleotide biosynthesis pathway cause spreading of silencing across heterochromatic barriers at the mating-type region of the fission yeast

31 March 2020

1 reference

Oncogene-induced senescence as an initial barrier in lymphoma development

31 March 2020

1 reference

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

31 March 2020

1 reference

Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer

31 March 2020

1 reference

Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer.

31 March 2020

1 reference

Remodeling chromatin for senescence

31 March 2020

1 reference

Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells

31 March 2020

1 reference

Loss of linker histone H1 in cellular senescence

31 March 2020

1 reference

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

31 March 2020

1 reference

A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation

31 March 2020

1 reference

Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging

31 March 2020

1 reference

Histone macroH2A isoforms predict the risk of lung cancer recurrence

31 March 2020

1 reference

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

31 March 2020

1 reference

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

31 March 2020

1 reference

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

31 March 2020

1 reference

Modulation of cellular radiation responses by histone deacetylase inhibitors

31 March 2020

1 reference

Inhibition of histone deacetylation: a strategy for tumor radiosensitization

31 March 2020

1 reference

Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes

31 March 2020

1 reference

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

31 March 2020

1 reference

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

31 March 2020

1 reference

Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias.

31 March 2020

1 reference

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

31 March 2020

1 reference

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

31 March 2020

1 reference

Site-specific DICER and DROSHA RNA products control the DNA-damage response

31 March 2020

1 reference

Global histone H4K20 trimethylation predicts cancer-specific survival in patients with muscle-invasive bladder cancer

31 March 2020

1 reference

12 December 2020

Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes.

1 reference

12 December 2020

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

1 reference

12 December 2020

Influence of chromatin structure on the induction of DNA double strand breaks by ionizing radiation

1 reference

12 December 2020

Mobilization and recruitment of HP1: a bimodal response to DNA breakage.

1 reference

12 December 2020

Down-regulation of HP1Hsalpha expression is associated with the metastatic phenotype in breast cancer

1 reference

12 December 2020

Expression of four histone lysine-methyltransferases in parotid gland tumors.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3344

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22952011%20AND%20SRC:MED&resulttype=core&format=json

24 May 2020

1 reference