(Q36389311)

13 August 2017

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title

Modulation of cellular radiation responses by histone deacetylase inhibitors (English)

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13 August 2017

Karagiannis TC

1

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13 August 2017

El-Osta A

series ordinal

2

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13 August 2017

language of work or name

English

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publication date

6 February 2006

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13 August 2017

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13 August 2017

25

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13 August 2017

3885-3893

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13 August 2017

28

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209417

13 August 2017

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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7 January 2021

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

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7 January 2021

Effects of nucleoside analogs and sodium butyrate on recovery from potentially lethal X ray damage in human colon tumor cells

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7 January 2021

Chemical agents that promote chromatin compaction radiosensitize tumour cells

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7 January 2021

Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies.

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7 January 2021

Antineoplastic action of 5-aza-2'-deoxycytidine and phenylbutyrate on human lung carcinoma cells

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7 January 2021

Valproate in bipolar disorder: 2000 onwards

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7 January 2021

Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation

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7 January 2021

The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

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7 January 2021

Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.

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7 January 2021

Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid

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7 January 2021

Enhancement of xenograft tumor radiosensitivity by the histone deacetylase inhibitor MS-275 and correlation with histone hyperacetylation

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7 January 2021

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Phase II study of phenylacetate in patients with recurrent malignant glioma: a North American Brain Tumor Consortium report.

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7 January 2021

Modulation of radiation response by histone deacetylase inhibition

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylases (HDACs): characterization of the classical HDAC family

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Acetylation of proteins as novel target for antitumor therapy: review article.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Prospects: histone deacetylase inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Clinical development of histone deacetylase inhibitors as anticancer agents

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7 January 2021

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

DNA double strand break repair and chromosomal translocation: lessons from animal models

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7 January 2021

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Binary switches and modification cassettes in histone biology and beyond.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Trifluoromethyl ketones as inhibitors of histone deacetylase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone acetylation and chromatin remodeling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone acetylation in chromatin structure and transcription

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase is a target of valproic acid-mediated cellular differentiation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase inhibitors and cancer: from cell biology to the clinic

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Sensing and repairing DNA double-strand breaks

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

The Greek Goddess, Artemis, reveals the secrets of her cleavage

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Translating the Histone Code

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylases specifically down-regulate p53-dependent gene activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Inhibitors of histone deacetylase as new anticancer agents

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Novel HDAC inhibitors with radiosensitizing properties

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Multiple signaling pathways involving ATM.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid

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7 January 2021

Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase inhibitors: from target to clinical trials

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Cancer risk and the ATM gene: a continuing debate

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Functional significance of histone deacetylase diversity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Substrate specificities and identification of putative substrates of ATM kinase family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone acetylases and deacetylases in cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Acetylation: a regulatory modification to rival phosphorylation?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Effects of sodium butyrate, a new pharmacological agent, on cells in culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Effects of Sodium Butyrate and 3-Aminobenzamide on Survival of Chinese Hamster HA-1 Cells after X Irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Mechanism and regulation of human non-homologous DNA end-joining

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Deacetylation of p53 modulates its effect on cell growth and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylases and cancer: causes and therapies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase inhibitors in programmed cell death and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Clinical pharmacology of sodium butyrate in patients with acute leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Phosphorylation of histone H2AX as a measure of radiosensitivity

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

A review of depsipeptide and other histone deacetylase inhibitors in clinical trials

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Chronic oral administration of CI-994: a phase 1 study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Defying death after DNA damage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Frequent chromosomal translocations induced by DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Megabase chromatin domains involved in DNA double-strand breaks in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

ATM: a mediator of multiple responses to genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Treatment of status epilepticus in children with rectal sodium valproate

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

An increasingly complex code

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone acetylation and transcriptional regulatory mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone Deacetylases: Unique Players in Shaping the Epigenetic Histone Code

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Cellular memory and the histone code

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Yeast DNA ligase IV mediates non-homologous DNA end joining

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

From discovery to the coming generation of histone deacetylase inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

ATM signaling and 53BP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209417

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209417

1 reference

Dimensions Publication ID

13 August 2017

0 references

1 reference