(Q14905498)

Protein-tyrosine phosphatase-like

1 reference

SH2 domain superfamily

1 reference

Tyrosine specific protein phosphatases domain, protein family

1 reference

SH2 domain, protein family

1 reference

PTP type protein phosphatase domain, protein family

1 reference

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

Protein-tyrosine phosphatase, active site, protein family

1 reference

phosphoprotein phosphatase activity

1 reference

25 May 2022

1 reference

25 May 2022

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

peptide hormone receptor binding

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

22 references

8 April 2019

An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Gab3, a new DOS/Gab family member, facilitates macrophage differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

non-membrane spanning protein tyrosine phosphatase activity

IPI

protein tyrosine phosphatase activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

receptor tyrosine kinase binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

cell adhesion molecule binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

megakaryocyte development

biological process

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

positive regulation of signal transduction

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

negative regulation of insulin secretion

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

regulation of cell adhesion mediated by integrin

intestinal epithelial cell migration

1 reference

8 April 2019

Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

neurotrophin TRK receptor signaling pathway

1 reference

8 April 2019

SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

epidermal growth factor receptor signaling pathway

1 reference

8 April 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

negative regulation of growth hormone secretion

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

1 reference

8 April 2019

SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

regulation of multicellular organism growth

1 reference

14 February 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

regulation of protein export from nucleus

1 reference

8 April 2019

DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

ephrin receptor signaling pathway

abortive mitotic cell cycle

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

DNA damage checkpoint signaling

1 reference

8 April 2019

DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium

microvillus organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

positive regulation of mitotic cell cycle

1 reference

8 April 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

hormone-mediated signaling pathway

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

integrin-mediated signaling pathway

IDA

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

platelet-derived growth factor receptor signaling pathway

1 reference

8 April 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

negative regulation of cortisol secretion

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

peptidyl-tyrosine dephosphorylation

negative regulation of hormone secretion

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

triglyceride metabolic process

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

hormone metabolic process

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

negative regulation of cell adhesion mediated by integrin

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

positive regulation of hormone secretion

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

multicellular organismal reproductive process

1 reference

8 April 2019

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

positive regulation of ERK1 and ERK2 cascade

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

SHP-2 is a novel target of Abl kinases during cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

cellular response to epidermal growth factor stimulus

positive regulation of interferon-beta production

1 reference

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

positive regulation of interleukin-6 production

1 reference

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235

1 reference

Protein-tyrosine phosphatase, catalytic

1 reference

PTP type protein phosphatase domain

1 reference

Tyrosine specific protein phosphatases domain

1 reference

Protein-tyrosine phosphatase, active site

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016