(Q23923913)

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Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2

journal article published in 2010

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scholarly article

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15 October 2024

Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2 (English)

1 reference

12 July 2017

NIOSH Health Effects Laboratory Division

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HELD

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25 September 2023

1 reference

15 October 2024

1 reference

15 October 2024

1 reference

29 March 2020

2

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Qiang Ma

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author name string

Xiaoqing He

1

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language of work or name

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publication date

January 2010

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Journal of Pharmacology and Experimental Therapeutics

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8 December 2019

332

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1

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66-75

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2802466/fullTextXML

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inferred from PubMed Central ID database lookup

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Wikimedia–NIOSH collaboration

0 references

NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation

2 references

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19 March 2017

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

2 references

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19 March 2017

Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2

2 references

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19 March 2017

Protection against Chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association

2 references

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19 March 2017

Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

2 references

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19 March 2017

Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice

2 references

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19 March 2017

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

2 references

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19 March 2017

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

2 references

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19 March 2017

Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2)

2 references

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19 March 2017

Superinduction of CYP1A1 gene expression. Regulation of 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced degradation of Ah receptor by cycloheximide

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802466

19 March 2017

Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer

2 references

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19 March 2017

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

2 references

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19 March 2017

Xenobiotic-activated receptors: from transcription to drug metabolism to disease

2 references

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19 March 2017

Activation of Nrf2 in defense against cadmium-induced oxidative stress

2 references

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19 March 2017

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

2 references

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19 March 2017

Tributyltin interacts with mitochondria and induces cytochrome c release

2 references

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19 March 2017

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

2 references

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19 March 2017

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

2 references

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19 March 2017

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802466

7 April 2017

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

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7 April 2017

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

1 reference

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27 September 2017

Acute promyelocytic leukemia: from highly fatal to highly curable

1 reference

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27 September 2017

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802466

27 September 2017

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

1 reference

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27 September 2017

Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress

1 reference

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27 September 2017

Arsenic: health effects, mechanisms of actions, and research issues

1 reference

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27 September 2017

Arsenical-resistant trypanosomes lack an unusual adenosine transporter

1 reference

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History of the treatment of psoriasis

1 reference

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27 September 2017

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

1 reference

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29 November 2018

Role of NRF2 in protection against hyperoxic lung injury in mice

1 reference

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29 November 2018

Identifiers

10.1124/JPET.109.160465

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