(Q24299895)

negative regulation of canonical Wnt signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Alexandra Schambony

5

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author name string

Kristina Tanneberger

1

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Astrid S Pfister

2

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Vitezslav Kriz

3

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Vitezslav Bryja

4

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Jürgen Behrens

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

3 June 2011

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published in

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volume

286

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issue

22

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page(s)

19204-14

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cites work

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation

1 reference

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19 March 2017

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Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling

19 March 2017

1 reference

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AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane

19 March 2017

1 reference

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The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

19 March 2017

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E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

19 March 2017

1 reference

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Wnt/beta-catenin signaling in development and disease

19 March 2017

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Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

19 March 2017

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

19 March 2017

1 reference

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beta-catenin destruction complex: insights and questions from a structural perspective

19 March 2017

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

19 March 2017

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Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

19 March 2017

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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

19 March 2017

1 reference

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LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin

19 March 2017

1 reference

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

19 March 2017

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A mechanism for Wnt coreceptor activation

19 March 2017

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Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

19 March 2017

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Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

19 March 2017

1 reference

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Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3103299

Proximal events in Wnt signal transduction

19 March 2017

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

7 April 2017

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Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes

7 April 2017

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Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

27 September 2017

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Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3103299

Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway.

27 September 2017

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Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3103299

Wnt/beta-catenin signaling: new (and old) players and new insights

27 September 2017

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Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3103299

An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

27 September 2017

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Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention.

27 September 2017

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Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK

27 September 2017

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The Wnt signaling pathway and its role in tumor development

27 September 2017

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Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling

27 September 2017

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Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3103299

Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin.

27 September 2017

1 reference

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https://api.crossref.org/works/10.1074%2FJBC.M111.224881

Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.224881

Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.224881

A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21498506