(Q24300906)

English

STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis

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scholarly article

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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis (English)

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1 reference

based on heuristic

inferred from title

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based on heuristic

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author name string

Ying Dunkel

1

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Andrew Ong

2

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Dimple Notani

3

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Yash Mittal

4

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Michael Lam

5

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Xiaoyi Mi

6

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Pradipta Ghosh

7

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language of work or name

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publication date

7 December 2012

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Journal of Biological Chemistry

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287

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50

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41667-83

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3516717/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Akt/PKB regulates actin organization and cell motility via Girdin/APE

1 reference

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Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles

1 reference

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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

1 reference

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Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer

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1 reference

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STATs and gene regulation

1 reference

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Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling

1 reference

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Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration

1 reference

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Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway

1 reference

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HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop

1 reference

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GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression

1 reference

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1 reference

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STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers

1 reference

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A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals

1 reference

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1 reference

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STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.

1 reference

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Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer

1 reference

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STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer

1 reference

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A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

1 reference

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dGirdin a new player of Akt /PKB signaling in Drosophila Melanogaster

1 reference

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A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate

1 reference

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Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.

1 reference

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Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

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STAT3 as a central regulator of tumor metastases

1 reference

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Reciprocal effects of STAT5 and STAT3 in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

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GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

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Activation of Galphai3 triggers cell migration via regulation of GIV.

1 reference

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Roles of unphosphorylated STATs in signaling

1 reference

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An actin-binding protein Girdin regulates the motility of breast cancer cells

1 reference

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Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

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Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases

1 reference

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Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation

1 reference

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Role of Stat3 in regulating p53 expression and function

1 reference

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Stat3 regulates genes common to both wound healing and cancer

1 reference

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27 September 2017

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

1 reference

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Temporal patterns of gene expression in murine cutaneous burn wound healing

1 reference

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

1 reference

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STAT proteins: novel molecular targets for cancer drug discovery

1 reference

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Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

27 September 2017

Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

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Inhibition of transcription factor binding to the HER2 promoter by triplex-forming oligodeoxyribonucleotides

1 reference

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The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

30 May 2018

Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

30 May 2018

Tumor progression in four mammary epithelial cell lines derived from the same patient

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

30 May 2018

Human skin transcriptome during superficial cutaneous wound healing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

29 November 2018

Girdin maintains the stemness of glioblastoma stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

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ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

29 November 2018

The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

29 November 2018

Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

29 November 2018

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

29 November 2018

A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

29 November 2018

Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

29 November 2018

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation

1 reference

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29 November 2018

Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

29 November 2018

Validating Stat3 in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical implications for girdin protein expression in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Girdin protein: a new potential distant metastasis predictor of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimer stability as a determinant of differential DNA binding activity of Stat3 isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of Stat3 and its target gene products with malignancy in human colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.390781

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