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ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth
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scholarly article
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title
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth
(English)
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main subject
Alsin Rho guanine nucleotide exchange factor ALS2
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stated in
GOA release 2020-03-11
neuron projection morphogenesis
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GOA release 2020-03-11
neurite
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inferred from title
author
Malcolm A Ward
object named as
Malcolm Ward
series ordinal
8
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Declan McLoughlin
object named as
Declan M McLoughlin
series ordinal
12
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Christopher Shaw
object named as
Christopher E Shaw
series ordinal
11
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P Nigel Leigh
series ordinal
10
object named as
P Nigel Leigh
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author name string
Elizabeth L Tudor
series ordinal
1
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Michael S Perkinton
series ordinal
2
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Anja Schmidt
series ordinal
3
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Steven Ackerley
series ordinal
4
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Janet Brownlees
series ordinal
5
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Nicholas J O Jacobsen
series ordinal
6
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Helen L Byers
series ordinal
7
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Alan Hall
series ordinal
9
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Christopher C J Miller
series ordinal
13
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language of work or name
English
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publication date
14 October 2005
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published in
Journal of Biological Chemistry
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volume
280
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page(s)
34735-40
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issue
41
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cites work
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Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood
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Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions
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Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.
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Rho GTPases in growth cone guidance
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Rac proteins and the control of axon development
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The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth
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Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression.
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The role of Rho GTPases and associated kinases in regulating neurite outgrowth
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The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings
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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
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Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo
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Rho GTPases in cell biology
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The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
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A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
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Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord
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Differential neurochemical properties of central serotonergic transmission in Roman high- and low-avoidance rats
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Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease
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The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease
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Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
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The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling
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The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice
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GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation
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A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death
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The genetics of motor neuron diseases
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The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.
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Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons.
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Crossref
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7 January 2021
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inferred from DOI database lookup
Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M506216200
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis
1 reference
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Crossref
reference URL
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inferred from DOI database lookup
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
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Crossref
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7 January 2021
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inferred from DOI database lookup
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.
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Crossref
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7 January 2021
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inferred from DOI database lookup
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics
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Crossref
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Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
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Crossref
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The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
1 reference
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Crossref
reference URL
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7 January 2021
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Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
1 reference
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inferred from DOI database lookup
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M506216200
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7 January 2021
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inferred from DOI database lookup
Unraveling the mechanisms involved in motor neuron degeneration in ALS
1 reference
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Crossref
reference URL
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inferred from DOI database lookup
Rac1 mediates collapsin-1-induced growth cone collapse
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Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: inhibition of collapse by opposing mutants of rac1
1 reference
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inferred from DOI database lookup
Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology.
1 reference
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Crossref
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Identifiers
DOI
10.1074/JBC.M506216200
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3544550
OpenCitations bibliographic resource ID
3544550
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3544550
PubMed ID
16049005
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3544550
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