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Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling
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instance of
scholarly article
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review article
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stated in
Europe PubMed Central
title
Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling
(English)
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main subject
clinical chemistry
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Serine/threonine kinase 4
1 reference
stated in
GOA release 2020-03-11
Serine/threonine kinase 3
1 reference
stated in
GOA release 2020-03-11
hippo signaling
1 reference
stated in
GOA release 2020-03-11
author
Brian Hemmings
series ordinal
2
object named as
Brian A Hemmings
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author name string
Alexander Hergovich
series ordinal
1
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language of work or name
English
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publication date
2009
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stated in
PubMed
published in
BioFactors
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volume
35
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page(s)
338-45
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issue
4
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cites work
Mammalian NDR protein kinases: from regulation to a role in centrosome duplication.
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The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP
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Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma
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Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
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Elucidation of a universal size-control mechanism in Drosophila and mammals
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FBIOF.47
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7 January 2021
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inferred from DOI database lookup
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks
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stated in
Crossref
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https://api.crossref.org/works/10.1002%2FBIOF.47
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7 January 2021
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inferred from DOI database lookup
Biosignaling of mammalian Ste20-related kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
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inferred from DOI database lookup
RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
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7 January 2021
based on heuristic
inferred from DOI database lookup
YAP1 increases organ size and expands undifferentiated progenitor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
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7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of Yes-associated protein in common solid tumors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Centrosome-associated NDR kinase regulates centrosome duplication
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of genes associated with tumorigenesis of retinoblastoma by microarray analysis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Men and sin: what's the difference?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A crucial role of WW45 in developing epithelial tissues in the mouse
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
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7 January 2021
based on heuristic
inferred from DOI database lookup
New genes involved in cancer identified by retroviral tagging
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
KLF4, p21 and context-dependent opposing forces in cancer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NDR kinases regulate essential cell processes from yeast to humans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Filling out the Hippo pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PI3K pathway alterations in cancer: variations on a theme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
LATS1 tumor suppressor regulates G2/M transition and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lats2, a putative tumor suppressor, inhibits G1/S transition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lats2 is an essential mitotic regulator required for the coordination of cell division.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contact-dependent inhibition of EGFR signaling by Nf2/Merlin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hippo signaling in organ size control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
"Stemness": transcriptional profiling of embryonic and adult stem cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Merlin is a potent inhibitor of glioma growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.47
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/BIOF.47
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4308644
OpenCitations bibliographic resource ID
4308644
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4308644
PubMed ID
19484742
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4308644
ResearchGate publication ID
26255578
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