(Q24318857)

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RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange

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scholarly article

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RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange (English)

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RasGEF domain family member 1B

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GOA release 2020-03-11

RasGEF domain family member 1A

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GOA release 2020-03-11

guanyl-nucleotide exchange factor activity

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GOA release 2020-03-11

Alfred Wittinghofer

4

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author name string

Elif Yaman

1

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Raphael Gasper

2

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Carolin Koerner

3

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Uygar H Tazebay

5

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language of work or name

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publication date

August 2009

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276

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16

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4607-16

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The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): potential role for Rap2 in promoting B cell migration.

1 reference

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Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors

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The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes

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Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins

1 reference

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Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation

1 reference

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Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins

1 reference

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GEFs and GAPs: critical elements in the control of small G proteins

1 reference

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Recognizing and defining true Ras binding domains I: biochemical analysis

1 reference

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Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach

1 reference

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The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins

1 reference

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Expression of rasgef1b in zebrafish

1 reference

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Structural and mechanistic insights into ras association domains of phospholipase C epsilon

1 reference

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Rap2-JNK removes synaptic AMPA receptors during depotentiation

1 reference

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Epac proteins: multi-purpose cAMP targets

1 reference

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Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements

1 reference

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Analysis of interaction between Ras and CDC25 guanine nucleotide exchange factor using yeast GAL4 two-hybrid system

1 reference

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The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

1 reference

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The structural basis of the activation of Ras by Sos

1 reference

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Rap1 signalling: adhering to new models

1 reference

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based on heuristic

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Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

1 reference

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Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

1 reference

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A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

1 reference

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Ras oncogenes: split personalities

1 reference

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Rap2 is required for Wnt/beta-catenin signaling pathway in Xenopus early development

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07166.X

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based on heuristic

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Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).

1 reference

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Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex

1 reference

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Mitogenic and oncogenic properties of the small G protein Rap1b

1 reference

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based on heuristic

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Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors

1 reference

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based on heuristic

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Activity of Rap1 is regulated by bombesin, cell adhesion, and cell density in NIH3T3 fibroblasts

1 reference

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based on heuristic

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Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2

1 reference

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based on heuristic

inferred from DOI database lookup

Discriminatory residues in Ras and Rap for guanine nucleotide exchange factor recognition

1 reference

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based on heuristic

inferred from DOI database lookup

PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2

1 reference

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based on heuristic

inferred from DOI database lookup

Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase

1 reference

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based on heuristic

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Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

1 reference

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based on heuristic

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Activation of the Rap GTPases in B Lymphocytes Modulates B Cell Antigen Receptor-induced Activation of Akt but Has No Effect on MAPK Activation

1 reference

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Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression

1 reference

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The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes

1 reference

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The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

1 reference

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based on heuristic

inferred from DOI database lookup

Crystal structure of the RUN domain of the RAP2-interacting protein x

1 reference

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Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration

1 reference

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based on heuristic

inferred from DOI database lookup

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1 reference

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based on heuristic

inferred from DOI database lookup

The Rap1 GTPase functions as a regulator of morphogenesis in vivo

1 reference

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based on heuristic

inferred from DOI database lookup

Possible involvement of Rap1 and Ras in glutamatergic synaptic transmission

1 reference

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based on heuristic

inferred from DOI database lookup

Coot: model-building tools for molecular graphics

1 reference

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based on heuristic

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Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The guanine nucleotide-binding switch in three dimensions

1 reference

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based on heuristic

inferred from DOI database lookup

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07166.X

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based on heuristic

inferred from DOI database lookup

Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07166.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative protein structure modeling of genes and genomes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07166.X

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based on heuristic

inferred from DOI database lookup

Small GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07166.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma

1 reference

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based on heuristic

inferred from DOI database lookup

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10.1111/J.1742-4658.2009.07166.X

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