(Q24322602)

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Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells

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Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells (English)

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Neurofibromin 1

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GOA release 2020-03-11

positive regulation of GTPase activity

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GOA release 2020-03-11

Neurofibromin 1

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GOA release 2020-03-11

Fibroblast growth factor 2

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GOA release 2020-03-11

Amy M. Munchhof

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object named as

Amy M Munchhof

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author name string

Fang Li

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Hilary A White

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Laura E Mead

4

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Theresa R Krier

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Amy Fenoglio

6

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Xiaohong Li

7

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Jin Yuan

8

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Feng-Chun Yang

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David A Ingram

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language of work or name

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publication date

1 June 2006

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Human Molecular Genetics

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15

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11

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1858-69

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Schwann cell lines derived from malignant peripheral nerve sheath tumors respond abnormally to platelet-derived growth factor-BB.

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7 January 2021

based on heuristic

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Targeting neovascular pericytes in neurofibromatosis type 1.

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7 January 2021

based on heuristic

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The neurofibromatosis type 1 gene encodes a protein related to GAP

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https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ras signaling from plasma membrane and endomembrane microdomains

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7 January 2021

based on heuristic

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Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

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7 January 2021

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Tumor vessel development and maturation impose limits on the effectiveness of anti-vascular therapy

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Imatinib as a paradigm of targeted therapies

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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Blood vessel formation: what is its molecular basis?

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NF1 tumor suppressor gene function: narrowing the GAP

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FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition

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7 January 2021

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Analysis of vascularity of human neurofibromas

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7 January 2021

based on heuristic

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A target for phosphoinositide 3-kinase: Akt/PKB.

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https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

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Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells

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PDGF receptors as cancer drug targets

1 reference

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7 January 2021

based on heuristic

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Neurofibromatosis type 1: piecing the puzzle together

1 reference

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Anti-angiogenic therapy: rationale, challenges and clinical studies

1 reference

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7 January 2021

based on heuristic

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Expression of angiogenic factors in neurofibromas

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

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Proteins regulating Ras and its relatives

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

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Inflammation and cancer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Nf1 has an essential role in endothelial cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Friends or foes - bipolar effects of the tumour stroma in cancer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical translation of angiogenesis inhibitors

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https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurofibromatosis: past, present, and future

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https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential activation of the Rac pathway by Ha-Ras and K-Ras

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurofibromas in NF1: Schwann cell origin and role of tumor environment

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

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based on heuristic

inferred from DOI database lookup

Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Double target for tumor mass destruction.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Origins of circulating endothelial cells and endothelial outgrowth from blood

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL108

7 January 2021

based on heuristic

inferred from DOI database lookup

Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells

1 reference

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7 January 2021

based on heuristic

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10.1093/HMG/DDL108

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