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The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1
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scholarly article
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title
The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1
(English)
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main subject
Rho/rac guanine nucleotide exchange factor (GEF) 2
1 reference
stated in
GOA release 2020-03-11
Ras homolog family member A
1 reference
stated in
GOA release 2020-03-11
Kinase suppressor of ras 1
1 reference
stated in
GOA release 2020-03-11
author
Anne-Claude Gingras
series ordinal
16
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Mitsuhiko Ikura
series ordinal
12
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Troy Ketela
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13
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Oliver A Kent
object named as
Oliver A Kent
series ordinal
5
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Christopher B Marshall
object named as
Christopher B Marshall
series ordinal
11
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Robert Rottapel
object named as
Robert Rottapel
series ordinal
18
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Ming-Sound Tsao
object named as
Ming-Sound Tsao
series ordinal
17
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author name string
Jane Cullis
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1
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David Meiri
series ordinal
2
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Maria Jose Sandi
series ordinal
3
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Nikolina Radulovich
series ordinal
4
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Mauricio Medrano
series ordinal
6
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Daphna Mokady
series ordinal
7
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Josee Normand
series ordinal
8
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Jose Larose
series ordinal
9
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Richard Marcotte
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10
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Jason Moffat
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14
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Benjamin G Neel
series ordinal
15
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language of work or name
English
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publication date
10 February 2014
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published in
Cancer Cell
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volume
25
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issue
2
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page(s)
181-95
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cites work
Tiam1 mutations in human renal-cell carcinomas
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of gef-h1, a guanine nucleotide exchange factor for RhoA, by DNA transfection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GEF-H1 over-expression in hepatocellular carcinoma promotes cell motility via activation of RhoA signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-α.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
Mammalian Ras interacts directly with the serine/threonine kinase Raf
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
KSR, a novel protein kinase required for RAS signal transduction
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA.
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Raf-1 by direct feedback phosphorylation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An essential role for Rac in Ras transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of the BRAF gene in human cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Patterns of somatic mutation in human cancer genomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
Active erk regulates microtubule stability in H-ras-transformed cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
KSR stimulates Raf-1 activity in a kinase-independent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Raf-1/MEK/MAPK pathway is necessary for the G2/M transition induced by nocodazole
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
ConSite: web-based prediction of regulatory elements using cross-species comparison
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
The Ras superfamily of GTPases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
KSR modulates signal propagation within the MAPK cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
The consensus coding sequences of human breast and colorectal cancers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
retrieved
7 January 2021
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inferred from DOI database lookup
MAP kinases in lung endothelial permeability induced by microtubule disassembly
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
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7 January 2021
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inferred from DOI database lookup
Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
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7 January 2021
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inferred from DOI database lookup
Epithelial-cadherin and beta-catenin expression changes in pancreatic intraepithelial neoplasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
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7 January 2021
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Pharmacologic inactivation of kinase suppressor of Ras1 sensitizes epidermal growth factor receptor and oncogenic Ras-dependent tumors to ionizing radiation treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
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7 January 2021
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Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
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7 January 2021
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Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
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7 January 2021
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Oncogenic mutations of PIK3CA in human cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.CCR.2014.01.025
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inferred from DOI database lookup
Identifiers
DOI
10.1016/J.CCR.2014.01.025
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4635736
OpenCitations bibliographic resource ID
4635736
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4635736
PubMed ID
24525234
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4635736
ResearchGate publication ID
260194959
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