(Q24631421)

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20 January 2020

4 references

2 October 2020

5 July 2021

19 July 2022

31 July 2022

Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22248668%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

0 references

1 reference

18 November 2019

1 reference

28 November 2019

1 reference

11 December 2019

1 reference

18 December 2019

1 reference

19 December 2019

1 reference

20 December 2019

1 reference

2 October 2020

1 reference

5 July 2021

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22248668%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

author name string

Esha Madan

1

1 reference

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20 January 2020

Madan Bhatt

3

1 reference

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20 January 2020

Uttam Pati

4

1 reference

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20 January 2020

Periannan Kuppusamy

5

1 reference

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20 January 2020

Abbas Ali Mahdi

6

1 reference

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20 January 2020

language of work or name

English

0 references

publication date

1 December 2011

11 references

18 November 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

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20 January 2020

2 October 2020

5 July 2021

19 July 2022

31 July 2022

11 references

18 November 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22248668%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

2 October 2020

5 July 2021

19 July 2022

31 July 2022

2

1 reference

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20 January 2020

issue

12

1 reference

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20 January 2020

page(s)

948-957

1 reference

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Creative Commons Attribution 2.5 Generic

20 January 2020

copyright license

10 references

18 November 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

2 October 2020

5 July 2021

19 July 2022

Two faces of p53: aging and tumor suppression

31 July 2022

cites work

1 reference

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Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

7 April 2017

1 reference

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Accelerated telomere shortening in response to life stress

7 April 2017

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

7 April 2017

1 reference

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AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

7 April 2017

1 reference

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TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence.

7 April 2017

1 reference

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7 April 2017

Surfing the p53 network

1 reference

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p53, the cellular gatekeeper for growth and division

7 April 2017

1 reference

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

7 April 2017

1 reference

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Gallium compound GaQ(3) -induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cells

7 April 2017

1 reference

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The IkappaB kinase - a bridge between inflammation and cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen

7 April 2017

1 reference

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p53 regulates mitochondrial respiration

7 April 2017

1 reference

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Roles of tumor suppressor and telomere maintenance genes in cancer and aging--an epidemiological study

7 April 2017

1 reference

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Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase

7 April 2017

1 reference

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Novel SCO2 mutation (G1521A) presenting as a spinal muscular atrophy type I phenotype

7 April 2017

1 reference

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Cytochrome c oxidase deficiency due to a novel SCO2 mutation mimics Werdnig-Hoffmann disease

7 April 2017

1 reference

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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

7 April 2017

1 reference

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Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

7 April 2017

1 reference

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7 April 2017

The genetics of ageing

1 reference

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7 April 2017

1 reference

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

7 April 2017

1 reference

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The antioxidant function of the p53 tumor suppressor

7 April 2017

1 reference

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Obesity, cigarette smoking, and telomere length in women

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

BRAFE600-associated senescence-like cell cycle arrest of human naevi

7 April 2017

1 reference

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

7 April 2017

1 reference

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

7 April 2017

1 reference

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Essential role of mouse telomerase in highly proliferative organs

7 April 2017

1 reference

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

7 April 2017

1 reference

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p53 mutant mice that display early ageing-associated phenotypes

7 April 2017

1 reference

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miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress.

7 April 2017

1 reference

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Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?

27 September 2017

1 reference

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p53, ROS and senescence in the control of aging

27 September 2017

1 reference

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Paradoxical suppression of cellular senescence by p53

27 September 2017

1 reference

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Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling

27 September 2017

1 reference

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Cytoplasmic functions of the tumour suppressor p53.

27 September 2017

1 reference

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Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Loss of function of Sco1 and its interaction with cytochrome c oxidase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Tumor suppressors and cell metabolism: a recipe for cancer growth

27 September 2017

1 reference

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Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Regulation of cancer cell metabolism by hypoxia-inducible factor 1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

ROS and p53: a versatile partnership

27 September 2017

1 reference

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Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity

27 September 2017

1 reference

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Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

The common biology of cancer and ageing

27 September 2017

1 reference

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Cellular senescence in cancer and aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

A pivotal role for p53: balancing aerobic respiration and glycolysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

p53: new roles in metabolism

27 September 2017

1 reference

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Short telomeres limit tumor progression in vivo by inducing senescence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

High-throughput telomere length quantification by FISH and its application to human population studies

27 September 2017

1 reference

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Hypoxia signalling controls metabolic demand

27 September 2017

1 reference

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p53 induced growth arrest versus apoptosis and its modulation by survival cytokines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

p53: at the crossroad between cancer and ageing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

The links between membrane composition, metabolic rate and lifespan

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Cell signaling, the essential role of O-GlcNAc!

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Increased p53 activity does not accelerate telomere-driven ageing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Inflammation-associated cancer: NF-kappaB is the lynchpin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics--current status and future prospects

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

AIF deficiency compromises oxidative phosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Heterozygous telomerase deficiency in mouse and man: when less is definitely not more.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

NF-kappaB: tumor promoter or suppressor?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Modulation of mammalian life span by the short isoform of p53.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Telomere length regulation during postnatal development and ageing in Mus spretus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

TP53 and MTOR crosstalk to regulate cellular senescence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

p53: Pro-aging or pro-longevity?

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Decision-making by p53 and mTOR.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

P53 and aging: A fresh look at an old paradigm

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Glycolysis links p53 function with NF-κB signaling: Impact on cancer and aging process

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

NF-kappaB signaling in the aging process

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Cells die with increased cytosolic ATP during apoptosis: a bioluminescence study with intracellular luciferase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

The DNA excision repair system of the highly radioresistant bacterium Deinococcus radiodurans is facilitated by the pentose phosphate pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282098

SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae

28 November 2018

1 reference

12 December 2020

Reactive oxygen species-mediated p53 core-domain modifications determine apoptotic or necrotic death in cancer cells

1 reference

12 December 2020

Telomere shortening in human coronary artery diseases

1 reference

12 December 2020

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

1 reference

12 December 2020

Identifiers

DOI

10.18632/ONCOTARGET.389

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22248668%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22248668%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

22248668

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22248668%20AND%20SRC:MED&resulttype=core&format=json