(Q24815444)

5 July 2017

A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment (English)

1 reference

5 July 2017

1 reference

1

Harvey J Clewell

1 reference

5 July 2017

Melvin E Andersen

2

1 reference

PubMed ID

11781169

5 July 2017

Hugh A Barton

series ordinal

3

1 reference

PubMed ID

11781169

5 July 2017

language of work or name

English

0 references

publication date

1 January 2002

1 reference

Environmental Health Perspectives

5 July 2017

1 reference

5 July 2017

110

1 reference

5 July 2017

85-93

1 reference

5 July 2017

1

1 reference

Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

5 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Risk assessment of chemical mixtures: biologic and toxicologic issues

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Computer simulation of cell growth governed by stochastic processes: application to clonal growth cancer models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Incorporation of pharmacokinetics in noncancer risk assessment: example with chloropentafluorobenzene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

The application of physiologically based pharmacokinetic modeling in human health risk assessment of hazardous substances

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Physiologically-based pharmacokinetic modeling and bioactivation of xenobiotics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Incorporating biological information in quantitative risk assessment: an example with methylene chloride

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Tissue dosimetry, pharmacokinetic modeling, and interspecies scaling factors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Saturable metabolism and its relationship to toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

An improved procedure for low-dose carcinogenic risk assessment from animal data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Extrapolation of animal toxicity to humans: interspecies comparisons in drug development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Biologically based pharmacodynamic models: tools for toxicological research and risk assessment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

What is an appropriate measure of exposure when testing drugs for carcinogenicity in rodents?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

A dosimetric analysis of behavioral effects of acute toluene exposure in rats and humans.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Investigation of the potential impact of benchmark dose and pharmacokinetic modeling in noncancer risk assessment

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Risk assessment extrapolations and physiological modeling.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Biologically motivated models for chemical risk assessment.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Limiting the uncertainty in risk assessment by the development of physiologically based pharmacokinetic and pharmacodynamic models.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

A new method for determining allowable daily intakes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

Adjusting Exposure Limits for Long and Short Exposure Periods Using A Physiological Pharmacokinetic Model

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1240697

A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment

28 November 2018

1 reference

12 December 2020

Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans

1 reference

12 December 2020

A physiologically based pharmacokinetic model for retinoic acid and its metabolites

1 reference

12 December 2020

Investigation of the impact of pharmacokinetic variability and uncertainty on risks predicted with a pharmacokinetic model for chloroform

1 reference

12 December 2020

Harmonization: Developing Consistent Guidelines for Applying Mode of Action and Dosimetry Information to Cancer and Noncancer Risk Assessment

1 reference

Crossref

https://api.crossref.org/works/10.1289%2FEHP.0211085

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1289/EHP.0211085

1 reference

5 July 2017

1 reference

5 July 2017

1 reference

PubMed ID

11781169