(Q26745817)

title

Small molecules targeting viral RNA (English)

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author name string

Thomas Hermann

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27307213%20AND%20SRC:MED&resulttype=core&format=json

Wiley interdisciplinary reviews. RNA

8 June 2020

publication date

16 June 2016

0 references

published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27307213%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27307213%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27307213%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

726-743

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27307213%20AND%20SRC:MED&resulttype=core&format=json

Drugs targeting the ribosome

8 June 2020

cites work

1 reference

Antibiotics that target protein synthesis

21 January 2018

1 reference

The central role of RNA in human development and cognition

21 January 2018

1 reference

The rise of regulatory RNA

21 January 2018

1 reference

Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.

21 January 2018

1 reference

The hepatitis C virus internal ribosome-entry site: a new target for antiviral research

21 January 2018

1 reference

Chemical and functional diversity of small molecule ligands for RNA.

21 January 2018

1 reference

Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry

21 January 2018

1 reference

RNA as a drug target: chemical, modelling, and evolutionary tools

21 January 2018

1 reference

Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes

21 January 2018

1 reference

Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges

21 January 2018

1 reference

Recent advances in developing small molecules targeting RNA.

21 January 2018

1 reference

Methods to enable the design of bioactive small molecules targeting RNA.

21 January 2018

1 reference

Aminoglycoside antibiotics: old drugs and new therapeutic approaches

21 January 2018

1 reference

Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production

21 January 2018

1 reference

Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme

21 January 2018

1 reference

The oxazolidinones: past, present, and future.

21 January 2018

1 reference

On the nature of antibiotic binding sites in ribosomes

21 January 2018

1 reference

Inhibition of HIV-1 Rev-RRE interaction by diphenylfuran derivatives

21 January 2018

1 reference

Inhibitors of protein-RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules

21 January 2018

1 reference

Discovery of selective, small-molecule inhibitors of RNA complexes--I. The Tat protein/TAR RNA complexes required for HIV-1 transcription

21 January 2018

1 reference

The design of RNA binders: targeting the HIV replication cycle as a case study

21 January 2018

1 reference

Targeting frameshifting in the human immunodeficiency virus

21 January 2018

1 reference

Structure based approaches for targeting non-coding RNAs with small molecules

21 January 2018

1 reference

Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays

21 January 2018

1 reference

Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR.

21 January 2018

1 reference

Artificial nucleobase-amino acid conjugates: a new class of TAR RNA binding agents

21 January 2018

1 reference

Bioavailable inhibitors of HIV-1 RNA biogenesis identified through a Rev-based screen

21 January 2018

1 reference

Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA

21 January 2018

1 reference

SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain

21 January 2018

1 reference

Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches

21 January 2018

1 reference

Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA.

21 January 2018

1 reference

Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site

21 January 2018

1 reference

2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

21 January 2018

1 reference

A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site.

21 January 2018

1 reference

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication

21 January 2018

1 reference

Targeting Influenza A Virus RNA Promoter

21 January 2018

1 reference

Anti-frameshifting ligand reduces the conformational plasticity of the SARS virus pseudoknot

21 January 2018

1 reference

Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins

21 January 2018

1 reference

Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates

21 January 2018

1 reference

Multivalency in the recognition and antagonism of a HIV TAR RNA-TAT assembly using an aminoglycoside benzimidazole scaffold

21 January 2018

1 reference

Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA.

21 January 2018

1 reference

Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1.

21 January 2018

1 reference

Small molecule modulators of HIV Rev/Rev response element interaction identified by random screening

21 January 2018

1 reference

Heterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication

21 January 2018

1 reference

Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells.

21 January 2018

1 reference

Hepatitis C therapeutics: current status and emerging strategies

21 January 2018

1 reference

Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules

21 January 2018

1 reference

Biaryl guanidine inhibitors of in vitro HCV-IRES activity

21 January 2018

1 reference

Ligand-responsive RNA mechanical switches

21 January 2018

1 reference

Functional conservation despite structural divergence in ligand-responsive RNA switches

21 January 2018

1 reference

Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution

21 January 2018

1 reference

An efficient new route to dihydropyranobenzimidazole inhibitors of HCV replication.

21 January 2018

1 reference

Structural and energetic analysis of 2-aminobenzimidazole inhibitors in complex with the hepatitis C virus IRES RNA using molecular dynamics simulations

21 January 2018

1 reference

Computational study of the structural plasticity and the ligand binding affinity of the IRES subdomain IIa.

21 January 2018

1 reference

A short guide for molecular dynamics simulations of RNA systems.

21 January 2018

1 reference

Catalytic metallodrugs targeting HCV IRES RNA.

21 January 2018

1 reference

Insight into the recognition, binding, and reactivity of catalytic metallodrugs targeting stem loop IIb of hepatitis C IRES RNA

21 January 2018

1 reference

Catalytic metallodrugs based on the LaR2C peptide target HCV SLIV IRES RNA.

21 January 2018

1 reference

Mechanisms and implications of programmed translational frameshifting

21 January 2018

1 reference

A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal

21 January 2018

1 reference

An atypical RNA pseudoknot stimulator and an upstream attenuation signal for -1 ribosomal frameshifting of SARS coronavirus

21 January 2018

1 reference

Programmed -1 frameshifting efficiency correlates with RNA pseudoknot conformational plasticity, not resistance to mechanical unfolding

21 January 2018

1 reference

Structure of influenza A polymerase bound to the viral RNA promoter

21 January 2018

1 reference

Biophysical analysis of influenza A virus RNA promoter at physiological temperatures

21 January 2018

1 reference

Structural features of an influenza virus promoter and their implications for viral RNA synthesis

21 January 2018

1 reference

Aminoglycoside antibiotics bind to the influenza A virus RNA promoter.

21 January 2018

1 reference

Carbon-oxygen hydrogen bonding in biological structure and function

21 January 2018

1 reference

C-H...O and other weak hydrogen bonds. From crystal engineering to virtual screening

21 January 2018

1 reference

Adaptive Ligand Binding by the Purine Riboswitch in the Recognition of Guanine and Adenine Analogs

21 January 2018

1 reference

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

21 January 2018

1 reference

Riboswitches as antibacterial drug targets

21 January 2018

1 reference

21 January 2018

1 reference

Functional RNA elements in the dengue virus genome

21 January 2018

1 reference

Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome

21 January 2018

1 reference

Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication

21 January 2018

1 reference

RNA Structure Duplications and Flavivirus Host Adaptation

21 January 2018

1 reference

Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic

21 January 2018

1 reference

Functional non-coding RNAs derived from the flavivirus 3' untranslated region.

21 January 2018

1 reference

RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA

21 January 2018

1 reference

Analysis of the role of predicted RNA secondary structures in Ebola virus replication

21 January 2018

1 reference

The Ebola virus genomic replication promoter is bipartite and follows the rule of six.

21 January 2018

1 reference

Filovirus replication and transcription

21 January 2018

1 reference

Characterization of Ebolavirus regulatory genomic regions

21 January 2018

1 reference

Ebola virus VP30-mediated transcription is regulated by RNA secondary structure formation

21 January 2018

1 reference

The marburg virus 3' noncoding region structurally and functionally differs from that of ebola virus

21 January 2018

1 reference

Kaposi's sarcoma-associated herpesvirus vCyclin open reading frame contains an internal ribosome entry site

21 January 2018

1 reference

Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein

21 January 2018

1 reference

Functional analysis of Kaposi's sarcoma-associated herpesvirus vFLIP expression reveals a new mode of IRES-mediated translation

21 January 2018

1 reference

New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA.

21 January 2018

1 reference

Structure and function of the encapsidation signal of hepadnaviridae.

21 January 2018

1 reference

Transcriptional Regulation in Ebola Virus: Effects of Gene Border Structure and Regulatory Elements on Gene Expression and Polymerase Scanning Behavior

21 January 2018

1 reference

KSHV vFLIP is essential for the survival of infected lymphoma cells

21 January 2018

1 reference

A polypyrimidine tract facilitates the expression of Kaposi's sarcoma-associated herpesvirus vFLIP through an internal ribosome entry site

21 January 2018

1 reference

Conservation of a triple-helix-forming RNA stability element in noncoding and genomic RNAs of diverse viruses

21 January 2018

1 reference

Poly(A) Tail Recognition by a Viral RNA Element Through Assembly of a Triple Helix

21 January 2018

1 reference

Hepatitis B virus replication

21 January 2018

1 reference

In vitro epsilon RNA-dependent protein priming activity of human hepatitis B virus polymerase.

21 January 2018

1 reference

Evidence for multiple distinct interactions between hepatitis B virus P protein and its cognate RNA encapsidation signal during initiation of reverse transcription

21 January 2018

1 reference

Sequences in the terminal protein and reverse transcriptase domains of the hepatitis B virus polymerase contribute to RNA binding and encapsidation

21 January 2018

1 reference

A SELEX-screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication.

21 January 2018

1 reference

Selective small-molecule inhibition of an RNA structural element

21 January 2018

1 reference

Targeting RNA with small molecules

21 January 2018

1 reference

12 December 2020

Targeting HIV transcription: the quest for a functional cure

1 reference

12 December 2020

Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA

1 reference

12 December 2020

The hepatitis C virus internal ribosome-entry site: a new target for antiviral research

1 reference

12 December 2020

Targeting hepatitis C virus translation: stopping HCV where it starts.

1 reference

12 December 2020

Throwing a spanner in the works: antibiotics and the translation apparatus

1 reference

12 December 2020

1 reference

12 December 2020

Design of novel RNA ligands that bind stem-bulge HIV-1 TAR RNA

1 reference

12 December 2020

Binding of neomycin to the TAR element of HIV-1 RNA induces dissociation of Tat protein by an allosteric mechanism

1 reference

12 December 2020

Targeting the HIV RNA genome: high-hanging fruit only needs a longer ladder

1 reference

12 December 2020

The influenza virus panhandle is involved in the initiation of transcription

1 reference

12 December 2020

Exploration of metal ion binding sites in RNA folds by Brownian-dynamics simulations

1 reference

12 December 2020

Promoter elements in the influenza vRNA terminal structure.

1 reference

12 December 2020

Hepatitis C IRES: translating translation into a therapeutic target

1 reference

12 December 2020

Identification of RNA pseudoknot-binding ligand that inhibits the -1 ribosomal frameshifting of SARS-coronavirus by structure-based virtual screening

1 reference

12 December 2020

Identifiers

DOI

10.1002/WRNA.1373

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27307213%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27307213%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PubMed publication ID

27307213

1 reference