(Q27025271)

Yun Xie

series ordinal

2

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Yitzhak Tor

series ordinal

3

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language of work or name

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2011

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Wiley interdisciplinary reviews. RNA

published in

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volume

2

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issue

2

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page(s)

209-32

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Oxazolidinones: activity, mode of action, and mechanism of resistance.

cites work

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Lipopeptides, focusing on daptomycin, for the treatment of Gram-positive infections

21 January 2018

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Targeting RNA with small molecules

21 January 2018

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Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation

21 January 2018

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Current topics in RNA-protein recognition: control of specificity and biological function through induced fit and conformational capture

21 January 2018

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Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition

21 January 2018

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Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme

21 January 2018

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Application of a Theory of Enzyme Specificity to Protein Synthesis

21 January 2018

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Induced fit in RNA-protein recognition

21 January 2018

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The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit

21 January 2018

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Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

21 January 2018

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Recognition of cognate transfer RNA by the 30S ribosomal subunit

21 January 2018

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Selection of tRNA by the ribosome requires a transition from an open to a closed form

21 January 2018

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Structure of the 70S ribosome complexed with mRNA and tRNA

21 January 2018

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The structures of four macrolide antibiotics bound to the large ribosomal subunit

21 January 2018

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Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit

21 January 2018

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Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

21 January 2018

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Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit

21 January 2018

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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

21 January 2018

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Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

21 January 2018

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Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

21 January 2018

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Structural insight into the role of the ribosomal tunnel in cellular regulation

21 January 2018

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Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression

21 January 2018

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Structural basis for the antibiotic activity of ketolides and azalides

21 January 2018

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Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

21 January 2018

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Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin

21 January 2018

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Structural basis for cross-resistance to ribosomal PTC antibiotics

21 January 2018

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Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

21 January 2018

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Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit

21 January 2018

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A Steric Block in Translation Caused by the Antibiotic Spectinomycin

21 January 2018

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Structural basis for hygromycin B inhibition of protein biosynthesis

21 January 2018

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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

21 January 2018

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The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation.

21 January 2018

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Structure-based drug design meets the ribosome

21 January 2018

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Refinement of the AMBER force field for nucleic acids: improving the description of alpha/gamma conformers

21 January 2018

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Molecular dynamics and quantum mechanics of RNA: conformational and chemical change we can believe in

21 January 2018

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Structures of the ribosome in intermediate states of ratcheting

21 January 2018

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Recognition of the codon-anticodon helix by ribosomal RNA.

21 January 2018

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Interaction of antibiotics with functional sites in 16S ribosomal RNA

21 January 2018

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RNA sequence determinants for aminoglycoside binding to an A-site rRNA model oligonucleotide

21 January 2018

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Thermodynamics of aminoglycoside-rRNA recognition: the binding of neomycin-class aminoglycosides to the A site of 16S rRNA.

21 January 2018

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Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic

21 January 2018

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Structural origins of gentamicin antibiotic action

21 January 2018

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Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site

21 January 2018

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Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site

21 January 2018

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Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide

21 January 2018

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Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding

21 January 2018

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Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex

21 January 2018

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Molecular recognition of RNA by neomycin and a restricted neomycin derivative.

21 January 2018

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Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group

21 January 2018

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Apramycin recognition by the human ribosomal decoding site

21 January 2018

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Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites

21 January 2018

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Inhibition of ribosomal translocation by aminoglycoside antibiotics

21 January 2018

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Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation

21 January 2018

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Catalysis of ribosomal translocation by sparsomycin

21 January 2018

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Rapid kinetic analysis of EF-G-dependent mRNA translocation in the ribosome

21 January 2018

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Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation

21 January 2018

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Aminoglycoside activity observed on single pre-translocation ribosome complexes

21 January 2018

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Sequence-specific recognition of the major groove of RNA by deoxystreptamine.

21 January 2018

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Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: an analysis of x-ray crystal structures

21 January 2018

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Aminoglycoside binding to human and bacterial A-Site rRNA decoding region constructs

21 January 2018

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Basis for prokaryotic specificity of action of aminoglycoside antibiotics

21 January 2018

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Structural origins of aminoglycoside specificity for prokaryotic ribosomes

21 January 2018

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Defining the basis for the specificity of aminoglycoside-rRNA recognition: a comparative study of drug binding to the A sites of Escherichia coli and human rRNA.

21 January 2018

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A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae

21 January 2018

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Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity

21 January 2018

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A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4.

21 January 2018

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How antibiotic-producing organisms avoid suicide

21 January 2018

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Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria

21 January 2018

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Inactivation of antibiotics and the dissemination of resistance genes

21 January 2018

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Contribution of the MexXY Multidrug Transporter to Aminoglycoside Resistance in Pseudomonas aeruginosa Clinical Isolates

21 January 2018

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Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens.

21 January 2018

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Aminoglycoside antibiotics: old drugs and new therapeutic approaches

21 January 2018

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Improving on nature: antibiotics that target the ribosome

21 January 2018

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Design, synthesis, and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics

21 January 2018

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Branched aminoglycosides: biochemical studies and antibacterial activity of neomycin B derivatives

21 January 2018

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Evaluation of amphiphilic aminoglycoside-peptide triazole conjugates as antibacterial agents

21 January 2018

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Conformational constraint as a means for understanding RNA-aminoglycoside specificity.

21 January 2018

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Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance

21 January 2018

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Design of novel antibiotics that bind to the ribosomal acyltransfer site

21 January 2018

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Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay

21 January 2018

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The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides

21 January 2018

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Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome

21 January 2018

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Structure-activity relationships of novel antibacterial translation inhibitors: 3,5-diamino-piperidinyl triazines.

21 January 2018

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Defining the molecular forces that determine the impact of neomycin on bacterial protein synthesis: importance of the 2'-amino functionality

21 January 2018

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The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography

21 January 2018

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Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry

21 January 2018

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Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins

21 January 2018

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A structure-based strategy to identify new molecular scaffolds targeting the bacterial ribosomal A-site

21 January 2018

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Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry

21 January 2018

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Measuring dissociation constants of RNA and aminoglycoside antibiotics by electrospray ionization mass spectrometry

21 January 2018

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SAR by MS: a ligand based technique for drug lead discovery against structured RNA targets

21 January 2018

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Discovery of aminoglycoside mimetics by NMR-based screening of Escherichia coli A-site RNA.

21 January 2018

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Application of NMR SHAPES screening to an RNA target.

21 January 2018

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Monitoring molecular recognition of the ribosomal decoding site

21 January 2018

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Fluorescence-based approach for detecting and characterizing antibiotic-induced conformational changes in ribosomal RNA: comparing aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA sequences.

21 January 2018

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FRET enabled real time detection of RNA-small molecule binding

21 January 2018

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Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites

21 January 2018

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How ribosomes make peptide bonds

21 January 2018

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Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction

21 January 2018

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An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA.

21 January 2018

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Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA.

21 January 2018

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Chloramphenicol resistance mutations in the single 23S rRNA gene of the archaeon Halobacterium halobium

21 January 2018

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Interaction of the antibiotics clindamycin and lincomycin with Escherichia coli 23S ribosomal RNA.

21 January 2018

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The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome

21 January 2018

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The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome

21 January 2018

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Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes.

21 January 2018

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Inhibition of protein synthesis by streptogramins and related antibiotics

21 January 2018

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Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis.

21 January 2018

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Oxazolidinone antibiotics.

21 January 2018

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Linezolid for the treatment of multidrug-resistant, gram-positive infections: experience from a compassionate-use program

21 January 2018

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Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors

21 January 2018

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Cross-linking in the Living Cell Locates the Site of Action of Oxazolidinone Antibiotics

21 January 2018

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The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.

21 January 2018

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Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center

21 January 2018

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Linezolid resistance in a clinical isolate of Staphylococcus aureus

21 January 2018

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Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics

21 January 2018

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Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics

21 January 2018

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The structural basis of ribosome activity in peptide bond synthesis

21 January 2018

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Regulatory nascent peptides in the ribosomal tunnel

21 January 2018

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Instruction of translating ribosome by nascent peptide

21 January 2018

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The ribosomal exit tunnel functions as a discriminating gate

21 January 2018

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Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A

21 January 2018

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Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin

21 January 2018

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Relationship of structures and microbiological activities of the 16-membered macrolides

21 January 2018

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Ketolides-telithromycin, an example of a new class of antibacterial agents

21 January 2018

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The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA.

21 January 2018

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Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

21 January 2018

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Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae

21 January 2018

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Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes.

21 January 2018

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Resistance phenotypes conferred by macrolide phosphotransferases.

21 January 2018

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Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins

21 January 2018

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Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae

21 January 2018

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Erythromycin resistance by ribosome modification

21 January 2018

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Macrolide resistance conferred by base substitutions in 23S rRNA.

21 January 2018

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Functional, biophysical, and structural bases for antibacterial activity of tigecycline

21 January 2018

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Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance

21 January 2018

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Ribosomal translocation: one step closer to the molecular mechanism

21 January 2018

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Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding

21 January 2018

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Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice.

21 January 2018

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Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin

21 January 2018

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Potential new antibiotic sites in the ribosome revealed by deleterious mutations in RNA of the large ribosomal subunit.

21 January 2018

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RNA as a drug target: chemical, modelling, and evolutionary tools

21 January 2018

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Discovery of novel antibacterials

21 January 2018

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The discovery of antibacterial agents using diversity-oriented synthesis

21 January 2018

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Recent developments in antibacterial drug discovery: microbe-derived natural products--from collection to the clinic

21 January 2018

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Controlling bacterial biofilms

21 January 2018

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The magic bullet in the new millennium -- cause for optimism.

21 January 2018

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Biochemical and kinetic characteristics of the interaction of the antitumor antibiotic sparsomycin with prokaryotic and eukaryotic ribosomes

21 January 2018

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Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit

21 January 2018

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Action of Sparsomycin on Ribosome-catalysed Peptidyl Transfer

21 January 2018

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