(Q26747418)

19 September 2019

cytoskeletal proteins

1 reference

11 December 2019

nerve tissue proteins

1 reference

19 December 2019

Clément Despres

7

0 references

Isabelle Huvent

Isabelle Huvent

4

0 references

Juan López

Juan Lopez

9

0 references

Isabelle Huvent

Isabelle Huvent

4

0 references

Isabelle Landrieu

Isabelle Landrieu

2

0 references

Neha S. Gandhi

Neha S Gandhi

5

0 references

Caroline Smet

Caroline Smet

3

0 references

Guy Lippens

Guy Lippens

1

0 references

author name string

Benoît Gigant

6

0 references

Haoling Qi

Creative Commons Attribution

8

0 references

language of work or name

English

0 references

publication date

2016

0 references

7 June 2016

3 references

19 September 2019

11 December 2019

19 December 2019

4 references

19 September 2019

11 December 2019

19 December 2019

6

0 references

issue

2

0 references

page(s)

28

0 references

copyright license

3 references

19 September 2019

11 December 2019

19 December 2019

0 references

Nuclear Tau and Its Potential Role in Alzheimer's Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Overexpression, purification, and functional analysis of recombinant human tubulin dimer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

A role for FKBP52 in Tau protein function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Transmission and spreading of tauopathy in transgenic mouse brain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Tau protein binds to microtubules through a flexible array of distributed weak sites

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

A protein factor essential for microtubule assembly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Stabilizer-Guided Inhibition of Protein-Protein Interactions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Folding of the Tau Protein on Microtubules

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Design and Characterization of Modular Scaffolds for Tubulin Assembly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Towards a Pharmacophore for Amyloid

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

The 4 A X-ray structure of a tubulin:stathmin-like domain complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Graded Control of Microtubule Severing by Tubulin Glutamylation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Assigning backbone NMR resonances for full length tau isoforms: efficient compromise between manual assignments and reduced dimensionality

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Structural polymorphism of 441-residue tau at single residue resolution

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Surface-decoration of microtubules by human tau

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Isomerization and Oligomerization of Truncated and Mutated Tau Forms by FKBP52 are Independent Processes

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Proline Conformation in a Functional Tau Fragment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Identification of disulfide cross-linked tau dimer responsible for tau propagation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Spin Labeling and Characterization of Tau Fibrils Using Electron Paramagnetic Resonance (EPR).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Structural Impact of Tau Phosphorylation at Threonine 231.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

The structure of fibrils from 'misfolded' proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Oligomer formation of tau protein hyperphosphorylated in cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Coupled folding and binding of the disordered protein PUMA does not require particular residual structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Molecular structures of amyloid and prion fibrils: consensus versus controversy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Imbalance of Hsp70 family variants fosters tau accumulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Taxol-stabilized microtubules promote the formation of filaments from unmodified full-length Tau in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Tau protein diffuses along the microtubule lattice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Systematic identification of tubulin-interacting fragments of the microtubule-associated protein Tau leads to a highly efficient promoter of microtubule assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

A diversity of assembly mechanisms of a generic amyloid fold

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

The acetylation of tau inhibits its function and promotes pathological tau aggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Solid-state NMR studies of amyloid fibril structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Acetylation of tau inhibits its degradation and contributes to tauopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

The propagation of prion-like protein inclusions in neurodegenerative diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Quantitative characterization of heparin binding to Tau protein: implication for inducer-mediated Tau filament formation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Development of tau aggregation inhibitors for Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Template-assisted filament growth by parallel stacking of tau.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Evidence for two distinct binding sites for tau on microtubules

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Random-coil chemical shifts of phosphorylated amino acids.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Structural characterization of the core of the paired helical filament of Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Conformational features of tau fibrils from Alzheimer's disease brain are faithfully propagated by unmodified recombinant protein

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Spectroscopic studies of GSK3{beta} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

NMR investigation of the interaction between the neuronal protein tau and the microtubules

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Oxidative regulation of fatty acid-induced tau polymerization.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Alzheimer's disease and tau proteins.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Proline-directed random-coil chemical shift values as a tool for the NMR assignment of the tau phosphorylation sites

31 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Graphical interpretation of Boolean operators for protein NMR assignments.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Selective backbone labelling of ILV methyl labelled proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

A new strategy for sequential assignment of intrinsically unstructured proteins based on 15N single isotope labelling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Automatic assignment of the intrinsically disordered protein Tau with 441-residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Unraveling a phosphorylation event in a folded protein by NMR spectroscopy: phosphorylation of the Pin1 WW domain by PKA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Global hairpin folding of tau in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

NMR analysis of a Tau phosphorylation pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

The "jaws" of the tau-microtubule interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Structural basis for the regulation of tubulin by vinblastine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Regions of tau implicated in the paired helical fragment core as defined by NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Difference in fibril core stability between two tau four-repeat domain proteins: a hydrogen-deuterium exchange coupled to mass spectrometry study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Amplification of Tau fibrils from minute quantities of seeds

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Accepting its Random Coil Nature Allows a Partial NMR Assignment of the Neuronal Tau Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Tau protein binding forms a 1nm thick layer along protofilaments without affecting the radial elasticity of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Theory and applications of the transferred nuclear overhauser effect to the study of the conformations of small ligands bound to proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Mechanism of Tau-Promoted Microtubule Assembly As Probed by NMR Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020028

Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919923

Fibrillogenic nuclei composed of P301L mutant tau induce elongation of P301L tau but not wild-type tau

28 November 2018

1 reference

12 December 2020

CH-π interaction in VQIVYK sequence elucidated by NMR spectroscopy is essential for PHF formation of tau

1 reference

12 December 2020

Tuning bulk electrostatics to regulate protein function

1 reference

12 December 2020

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

1 reference

12 December 2020

Isotopically discriminated NMR spectroscopy: a tool for investigating complex protein interactions in vitro

1 reference

12 December 2020

C-H ... π interplay between Ile308 and Tyr310 residues in the third repeat of microtubule binding domain is indispensable for self-assembly of three- and four-repeat tau

1 reference

12 December 2020

Binding of vinblastine to stabilized microtubules

1 reference

12 December 2020

A six-dimensional alpha proton detection-based APSY experiment for backbone assignment of intrinsically disordered proteins

1 reference

12 December 2020

Negative nuclear Overhauser effects as probes of macromolecular structure

1 reference

12 December 2020

The dynamic structure of filamentous tau

1 reference

12 December 2020

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

1 reference

12 December 2020