(Q46533399)

http://europepmc.org/abstract/MED/26192747

22 December 2017

title

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice (English)

1 reference

http://europepmc.org/abstract/MED/26192747

22 December 2017

author

Meaghan Morris

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Sumihiro Maeda

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

7

Lennart Mucke

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

author name string

Giselle M Knudsen

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Jonathan C Trinidad

4

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14 June 2020

Alexandra Ioanoviciu

5

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14 June 2020

Alma L Burlingame

6

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14 June 2020

language of work or name

English

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publication date

20 July 2015

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http://europepmc.org/abstract/MED/26192747

22 December 2017

published in

Nature Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

volume

18

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14 June 2020

page(s)

1183-1189

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14 June 2020

issue

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nn.4067

14 June 2020

exact match

0 references

cites work

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Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

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Antisense reduction of tau in adult mice protects against seizures

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Tau reduction prevents disease in a mouse model of Dravet syndrome

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Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

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Seizure resistance without parkinsonism in aged mice after tau reduction

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Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

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Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

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The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

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Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry

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Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

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Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

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Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

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Acetylation of tau inhibits its degradation and contributes to tauopathy

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Protein PTMs: post-translational modifications or pesky trouble makers?

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Non-histone protein methylation as a regulator of cellular signalling and function

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Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

21 January 2018

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Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice

21 January 2018

1 reference

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

21 January 2018

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Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

21 January 2018

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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

21 January 2018

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Tau isoform regulation is region- and cell-specific in mouse brain.

21 January 2018

1 reference

Lysine acetylation: codified crosstalk with other posttranslational modifications

21 January 2018

1 reference

The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains

21 January 2018

1 reference

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

21 January 2018

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Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

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Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.

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Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

21 January 2018

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High-yield purification of fetal tau preserving its structure and phosphorylation pattern

21 January 2018

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Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice

21 January 2018

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Phosphorylation state of postsynaptic density proteins

21 January 2018

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Comprehensive identification of phosphorylation sites in postsynaptic density preparations

21 January 2018

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Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

21 January 2018

1 reference

Identification of protein O-GlcNAcylation sites using electron transfer dissociation mass spectrometry on native peptides

21 January 2018

1 reference

Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse

21 January 2018

1 reference

O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry

21 January 2018

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21 January 2018

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21 January 2018

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Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease

21 January 2018

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Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments

21 January 2018

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12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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12 December 2020

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.

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12 December 2020

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1 reference

12 December 2020

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

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12 December 2020

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization

1 reference

12 December 2020

Identifiers

DOI

10.1038/NN.4067

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference