(Q26747572)

title

One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug (English)

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27199640%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Katarina Nikolic

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27199640%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Rona R Ramsay

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27199640%20AND%20SRC:MED&resulttype=core&format=json

Frontiers in Neuroscience

6 June 2020

language of work or name

English

0 references

publication date

2016

0 references

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27199640%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27199640%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

177

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27199640%20AND%20SRC:MED&resulttype=core&format=json

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

6 June 2020

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28 September 2017

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28 September 2017

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Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis

28 September 2017

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AlzPlatform: an Alzheimer's disease domain-specific chemogenomics knowledgebase for polypharmacology and target identification research

28 September 2017

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Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease

28 September 2017

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Fyn kinase inhibition as a novel therapy for Alzheimer's disease

28 September 2017

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Drug repositioning: an opportunity to develop novel treatments for Alzheimer's disease

28 September 2017

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Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease

28 September 2017

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Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

28 September 2017

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Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.

28 September 2017

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The multifactorial nature of Alzheimer's disease for developing potential therapeutics.

28 September 2017

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Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro

28 September 2017

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Therapeutics of Alzheimer's disease: Past, present and future

28 September 2017

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Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline

28 September 2017

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28 September 2017

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Multitarget ligands in antibacterial research: progress and opportunities

28 September 2017

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The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of [...]

28 September 2017

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Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease

28 September 2017

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Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

28 September 2017

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28 September 2017

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A phase II trial of huperzine A in mild to moderate Alzheimer disease

28 September 2017

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Neuroprotective therapeutics for Alzheimer's disease: progress and prospects

28 September 2017

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28 September 2017

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28 September 2017

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Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy

28 September 2017

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Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease

28 September 2017

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Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Modifications of neuronal phosphorylated tau immunoreactivity induced by NMDA toxicity

28 September 2017

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28 September 2017

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Site-Activated Chelators Derived from Anti-Parkinson Drug Rasagiline as a Potential Safer and More Effective Approach to the Treatment of Alzheimer’s Disease

31 May 2018

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31 May 2018

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Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition

31 May 2018

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Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.

31 May 2018

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Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride

31 May 2018

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N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.

28 November 2018

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Wnt signaling pathway, a potential target for Alzheimer's disease treatment, is activated by a novel multitarget compound ASS234.

28 November 2018

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Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.

28 November 2018

1 reference

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Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease

28 November 2018

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Synthesis, molecular modeling and evaluation of novel N'-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aβ aggregation

28 November 2018

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Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

28 November 2018

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Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases

28 November 2018

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Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors

28 November 2018

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The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

28 November 2018

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Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

28 November 2018

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Drug discovery. Repurposing with a difference.

28 November 2018

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Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

28 November 2018

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Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo

28 November 2018

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A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease

28 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27199640

12 December 2020

inferred from PubMed ID database lookup

Immunotherapy for Alzheimer's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27199640

12 December 2020

inferred from PubMed ID database lookup

Parallel Screening: A Novel Concept in Pharmacophore Modeling and Virtual Screening†

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27199640

12 December 2020

inferred from PubMed ID database lookup

Cheminformatic/bioinformatic analysis of large corporate databases: Application to drug repurposing

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFNINS.2016.00177

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3389/FNINS.2016.00177

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27199640%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27199640%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

27199640

2 references