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Hedgehog signalling
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scholarly article
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review article
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title
Hedgehog signalling
(English)
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main subject
hedgehog protein
1 reference
stated in
PubMed
signal transduction
1 reference
stated in
PubMed
author
Philip W Ingham
object named as
Philip W Ingham
series ordinal
3
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author name string
Raymond Teck Ho Lee
series ordinal
1
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Zhonghua Zhao
series ordinal
2
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language of work or name
English
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publication date
1 February 2016
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published in
Development
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volume
143
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issue
3
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page(s)
367-72
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cites work
Noncanonical Hedgehog signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling mechanisms of non-conventional axon guidance cues: the Shh, BMP and Wnt morphogens.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hedgehog signalling: Kif7 is not that fishy after all.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of lipid metabolism in smoothened derepression in hedgehog signaling
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endocytosis of Hedgehog through dispatched regulates long-range signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling networks organizing regenerative growth of the zebrafish fin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wing tips: The wing disc as a platform for studying Hedgehog signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developmental roles and clinical significance of hedgehog signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sonic hedgehog induces the segregation of patched and smoothened in endosomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hedgehog signalling in the mouse requires intraflagellar transport proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ESCRT machinery regulates the secretion and long-range activity of Hedgehog.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Orchestrating ontogenesis: variations on a theme by sonic hedgehog
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The primary cilium: a signalling centre during vertebrate development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms and functions of Hedgehog signalling across the metazoa
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mechanisms of Hedgehog signalling and its roles in development and disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of heterotrimeric G proteins by Smoothened
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endocannabinoids are conserved inhibitors of the Hedgehog pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interactions between Hedgehog proteins and their binding partners come into view
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hedgehog signaling in animal development: paradigms and principles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Patched1 regulates hedgehog signaling at the primary cilium
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequential phosphorylation of smoothened transduces graded hedgehog signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppressor of fused regulates Gli activity through a dual binding mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytonemes as specialized signaling filopodia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1242%2FDEV.120154
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1242/DEV.120154
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PubMed ID
26839340
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