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Fine-tuning multiprotein complexes using small molecules
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Europe PubMed Central
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3517816
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
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5 February 2020
title
Fine-tuning multiprotein complexes using small molecules
(English)
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
3517816
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
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5 February 2020
author
Amanda Dugan
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2
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Europe PubMed Central
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3517816
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
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5 February 2020
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Andrea D Thompson
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1
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Europe PubMed Central
PMC publication ID
3517816
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
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5 February 2020
Jason E Gestwicki
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3
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3517816
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
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5 February 2020
Anna K Mapp
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4
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3517816
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5 February 2020
language of work or name
English
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publication date
23 July 2012
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3517816
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5 February 2020
published in
ACS Chemical Biology
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stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
3517816
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
volume
7
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
3517816
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
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5 February 2020
issue
8
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
3517816
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
page(s)
1311-1320
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Europe PubMed Central
PMC publication ID
3517816
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
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5 February 2020
cites work
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Shape shifting leads to small-molecule allosteric drug discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Estimating the size of the human interactome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Towards a proteome-scale map of the human protein–protein interaction network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Diversity of protein-protein interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Development of thioquinazolinones, allosteric Chk1 kinase inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structure of the Hsp110:Hsc70 nucleotide exchange machine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structural Basis of J Cochaperone Binding and Regulation of Hsp70
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structural basis of IAP recognition by Smac/DIABLO
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Site-directed ligand discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structural analysis of substrate binding by the molecular chaperone DnaK
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Solution structure of the tetrameric minimum transforming domain of p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
The atomic structure of protein-protein recognition sites
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Gene activation by dissociation of an inhibitor from a transcriptional activation domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Uniform binding of aminoacyl-tRNAs to elongation factor Tu by thermodynamic compensation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Drug discovery: a historical perspective
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
How many drug targets are there?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Navigating chemical space for biology and medicine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Microtubule polymerization dynamics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
An essential switch in subunit composition of a chromatin remodeling complex during neural development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
The druggable genome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Biological and chemical approaches to diseases of proteostasis deficiency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Evolutionarily conserved networks of residues mediate allosteric communication in proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Unraveling hot spots in binding interfaces: progress and challenges
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Evolutionarily conserved pathways of energetic connectivity in protein families
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
7 April 2017
Structure-based model of allostery predicts coupling between distant sites
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Structural biology and drug discovery of difficult targets: the limits of ligandability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Heat shock protein 70 kDa chaperone/DnaJ cochaperone complex employs an unusual dynamic interface.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Caught in the act: covalent cross-linking captures activator-coactivator interactions in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Recent trends and observations in the design of high-quality screening collections
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
A homogeneous fluorescence resonance energy transfer system for monitoring the activation of a protein switch in real time
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Importazole, a small molecule inhibitor of the transport receptor importin-β
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Tuning the affinity of aminoacyl-tRNA to elongation factor Tu for optimal decoding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
The rise of fragment-based drug discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Treatment of systemic lupus erythematosus with epratuzumab.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Full protein flexibility is essential for proper hot-spot mapping.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Grand challenge commentary: Accessing new chemical space for 'undruggable' targets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Transient protein-protein interactions: structural, functional, and network properties
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Post-translational modifications in signal integration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Genetic chemistry: production of non-native compounds in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Electrophilic tuning of the chemoprotective natural product sulforaphane.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Enhancements of screening collections to address areas of unmet medical need: an industry perspective
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Current strategies for diversity-oriented synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Selecting chemicals: the emerging utility of DNA-encoded libraries
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Drugging challenging targets using fragment-based approaches
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Ligand detection in the allosteric world
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Allosteric inhibition of human porphobilinogen synthase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Ras signaling and therapies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Inhibitor hijacking of Akt activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
ATP-dependent chromatin remodeling in neural development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Covalent modifiers: an orthogonal approach to drug design
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Predicting druggable binding sites at the protein-protein interface.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Photocrosslinkers illuminate interactions in living cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
A structural understanding of the dynamic ribosome machine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
The biological impact of mass-spectrometry-based proteomics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
PocketDepth: a new depth based algorithm for identification of ligand binding sites in proteins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Methods for the detection and analysis of protein-protein interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Whence cometh the allosterome?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
A common allosteric site and mechanism in caspases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Type II cadherin ectodomain structures: implications for classical cadherin specificity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Protein surface recognition and proteomimetics: mimics of protein surface structure and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Protein translocation by the Sec61/SecY channel
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Methyl groups as probes of structure and dynamics in NMR studies of high-molecular-weight proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
The PDBbind database: collection of binding affinities for protein-ligand complexes with known three-dimensional structures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Defining interacting partners for drug discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
From the cradle to the grave: molecular chaperones that may choose between folding and degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Drug-like properties and the causes of poor solubility and poor permeability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Structural and mechanistic aspects of evolution of beta-lactamases and penicillin-binding proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 September 2017
Computational methods for identifying a layered allosteric regulatory mechanism for ALS-causing mutations of Cu-Zn superoxide dismutase 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
31 May 2018
Impact of nonnatural amino acid mutagenesis on the in vivo function and binding modes of a transcriptional activator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
31 May 2018
InterProSurf: a web server for predicting interacting sites on protein surfaces
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
31 May 2018
High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
Application of an allosteric model to describe the interactions among retinol binding protein 4, transthyretin, and small molecule retinol binding protein 4 ligands
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
Intramolecular signaling pathways revealed by modeling anisotropic thermal diffusion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
Structural characterisation and functional significance of transient protein-protein interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
Signal sequences control gating of the protein translocation channel in a substrate-specific manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
Dimerization as a regulatory mechanism in signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517816
retrieved
28 November 2018
Biochemistry. Exciting structures
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22725693
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1021/CB300255P
1 reference
stated in
Europe PubMed Central
PMC publication ID
3517816
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
PMC publication ID
3517816
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
3517816
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
PubMed publication ID
22725693
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
3517816
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22725693%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
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