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Beyond empiricism: informing vaccine development through innate immunity research
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scholarly article
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PubMed
title
Beyond empiricism: informing vaccine development through innate immunity research
(English)
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stated in
PubMed
main subject
vaccine development
0 references
vaccine
1 reference
based on heuristic
inferred from title
author name string
Stuart M. Levitz
series ordinal
1
1 reference
stated in
Crossref
Douglas T. Golenbock
series ordinal
2
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stated in
Crossref
language of work or name
English
1 reference
stated in
PubMed
publication date
16 March 2012
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stated in
PubMed
published in
Cell
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stated in
PubMed
volume
148
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stated in
PubMed
issue
6
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stated in
PubMed
page(s)
1284-92
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PubMed
cites work
STING is a direct innate immune sensor of cyclic di-GMP
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7 April 2017
Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
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7 April 2017
Immune signaling by RIG-I-like receptors
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7 April 2017
Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant
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7 April 2017
Future Vaccination Strategies against Tuberculosis: Thinking outside the Box
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7 April 2017
Vaccines with aluminum-containing adjuvants: optimizing vaccine efficacy and thermal stability
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7 April 2017
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
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7 April 2017
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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7 April 2017
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
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7 April 2017
What led to the Nigerian boycott of the polio vaccination campaign?
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7 April 2017
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling
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7 April 2017
Lyme disease: Uphill Struggle
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7 April 2017
An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells
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7 April 2017
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
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7 April 2017
Rational design of a meningococcal antigen inducing broad protective immunity
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7 April 2017
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
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7 April 2017
Pathogen recognition and innate immunity
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7 April 2017
Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis
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7 April 2017
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
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7 April 2017
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
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7 April 2017
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
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7 April 2017
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
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7 April 2017
Promiscuous peptide of 16 kDa antigen linked to Pam2Cys protects against Mycobacterium tuberculosis by evoking enduring memory T-cell response
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28 September 2017
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
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28 September 2017
Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis
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28 September 2017
Assessing the safety of adjuvanted vaccines
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28 September 2017
Safety and efficacy of the RTS, S/AS01 E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial
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28 September 2017
Immunological mechanisms of vaccination
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28 September 2017
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.
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28 September 2017
Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88
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PubMed Central
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28 September 2017
Salmonella synthesizing 1-dephosphorylated [corrected] lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity.
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28 September 2017
Regulation of the antimicrobial response by NLR proteins.
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28 September 2017
Myeloid C-type lectin receptors in pathogen recognition and host defense
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28 September 2017
ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells.
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PubMed Central
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28 September 2017
The safety evaluation of adjuvants during vaccine development: the AS04 experience
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28 September 2017
Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines
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28 September 2017
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
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28 September 2017
Microbial manipulation of receptor crosstalk in innate immunity
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28 September 2017
Programming the magnitude and persistence of antibody responses with innate immunity
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28 September 2017
Targeted antigen delivery and activation of dendritic cells in vivo: steps towards cost effective vaccines
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28 September 2017
Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity.
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28 September 2017
The unexpected link between infection-induced apoptosis and a TH17 immune response.
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28 September 2017
Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine
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28 September 2017
Flagellin as an adjuvant: cellular mechanisms and potential.
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28 September 2017
Reverse vaccinology: developing vaccines in the era of genomics
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28 September 2017
Vaccine adjuvants: putting innate immunity to work
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28 September 2017
Robust stimulation of humoral and cellular immune responses following vaccination with antigen-loaded beta-glucan particles
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28 September 2017
New adjuvants for human vaccines
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28 September 2017
Sensing and signaling in antiviral innate immunity
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28 September 2017
The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant
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28 September 2017
Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate
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28 September 2017
Intracellular DNA recognition
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28 September 2017
Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists
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28 September 2017
Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination
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28 September 2017
AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity
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28 September 2017
MF59-adjuvanted versus non-adjuvanted influenza vaccines: integrated analysis from a large safety database.
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28 September 2017
Towards an understanding of the adjuvant action of aluminium
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28 September 2017
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines
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28 September 2017
Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant
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28 September 2017
Molecular and cellular signatures of human vaccine adjuvants.
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28 September 2017
A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression
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28 September 2017
How do adjuvants work? Important considerations for new generation adjuvants
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28 September 2017
Review of hepatitis B surface antigen-1018 ISS adjuvant-containing vaccine safety and efficacy.
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28 September 2017
Cross-protection against H5N1 influenza virus infection is afforded by intranasal inoculation with seasonal trivalent inactivated influenza vaccine.
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28 September 2017
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.
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28 September 2017
Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only
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28 September 2017
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
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28 September 2017
In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
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28 September 2017
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
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28 September 2017
Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts
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28 September 2017
Generation of a Listeria vaccine strain by enhanced caspase-1 activation
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31 May 2018
The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity
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31 May 2018
Promotion of B cell immune responses via an alum-induced myeloid cell population
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31 May 2018
Vaccines for the twenty-first century society.
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28 November 2018
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children
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28 November 2018
DNA released from dying host cells mediates aluminum adjuvant activity
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28 November 2018
Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125, STF2.HA1 SI).
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125
retrieved
28 November 2018
Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125
retrieved
28 November 2018
An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125
retrieved
28 November 2018
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125
retrieved
28 November 2018
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125
retrieved
28 November 2018
A model vaccine exploiting fungal mannosylation to increase antigen immunogenicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125
retrieved
28 November 2018
Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125
retrieved
28 November 2018
Dendritic cells internalize vaccine adjuvant after intramuscular injection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125
retrieved
28 November 2018
Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22424235
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22424235
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Toll-dependent selection of microbial antigens for presentation by dendritic cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22424235
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22424235
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22424235
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The nonspecific effects of vaccines and the expanded program on immunization
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22424235
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELL.2012.02.012
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1600214
Fatcat ID
release_rnpl53lnhfeyvol24u4bizjczy
0 references
OpenCitations bibliographic resource ID
1600214
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1600214
PMCID
3308125
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1600214
PubMed ID
22424235
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1600214
ResearchGate publication ID
221712669
0 references
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