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The multidrug transporter P-glycoprotein in pharmacoresistance to antiepileptic drugs
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title
The multidrug transporter P-glycoprotein in pharmacoresistance to antiepileptic drugs
(English)
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PubMed
main subject
multiple drug resistance
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author
Stanisław Jerzy Czuczwar
series ordinal
4
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Czuczwar SJ
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PubMed
author name string
Stępień KM
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1
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PubMed
Tomaszewski M
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2
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PubMed
Tomaszewska J
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3
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PubMed
language of work or name
English
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PubMed
publication date
2012
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published in
Pharmacological Reports
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PubMed
volume
64
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PubMed
issue
5
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PubMed
page(s)
1011-9
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PubMed
cites work
Exposure to antiepileptic drugs does not alter the functionality of P-glycoprotein in brain capillary endothelial and kidney cell lines.
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7 January 2021
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Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy
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Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain
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Cerebral expression of drug transporters in epilepsy
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Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays.
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7 January 2021
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Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein
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A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier
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The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy
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Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis
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Epilepsy
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Patients' experiences of injury as a result of epilepsy.
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Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein
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Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents.
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Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study
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Pharmacoresistance: modern concept and basic data derived from human brain tissue
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Epileptic seizures caused by low valproic acid levels from an interaction with meropenem
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Identification of the in vivo phosphorylation sites for acidic-directed kinases in murine mdr1b P-glycoprotein.
1 reference
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7 January 2021
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C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation
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Genetic analysis of the multidrug transporter
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The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research
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7 January 2021
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ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis
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Crossref
reference URL
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Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)
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7 January 2021
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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
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Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.
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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
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Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy
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Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy
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Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis
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Functional test of multidrug transporter activity in hippocampal-neocortical brain slices from epileptic patients
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Potential role of drug transporters in the pathogenesis of medically intractable epilepsy
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Drug-resistant epilepsy
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Basic mechanisms of antiepileptic drugs and their pharmacokinetic/pharmacodynamic interactions: an update
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Potential role of multidrug resistant proteins in refractory epilepsy and antiepileptic drugs interactions
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7 January 2021
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ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy
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Mitochondrial superoxide production in kainate-induced hippocampal damage.
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The clinical impact of pharmacogenetics on the treatment of epilepsy
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Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected
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7 January 2021
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inferred from DOI database lookup
Drug resistance in brain diseases and the role of drug efflux transporters.
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reference URL
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7 January 2021
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inferred from DOI database lookup
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
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7 January 2021
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Role of multidrug transporters in pharmacoresistance to antiepileptic drugs
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Crossref
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Several major antiepileptic drugs are substrates for human P-glycoprotein
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
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The effect of carbapenem antibiotics on plasma concentrations of valproic acid
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
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inferred from DOI database lookup
Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
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Antiepileptic drugs modulate P-glycoproteins in the brain: a mice study with (11)C-desmethylloperamide.
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
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Association of ABCB1 genetic variants 3435C>T and 2677G>T to ABCB1 mRNA and protein expression in brain tissue from refractory epilepsy patients.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
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Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain
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7 January 2021
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Predisposition to epilepsy--does the ABCB1 gene play a role?
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7 January 2021
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Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey
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7 January 2021
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ABCG2: structure, function and role in drug response
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
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Modulating P-glycoprotein regulation: future perspectives for pharmacoresistant epilepsies?
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular and cellular mechanisms of pharmacoresistance in epilepsy
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
retrieved
7 January 2021
based on heuristic
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Why does epilepsy become intractable? Prevention of chronic epilepsy
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Does P-glycoprotein play a role in pharmacoresistance to antiepileptic drugs?
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
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New developments in antiepileptic drug resistance: an integrative view
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Multidrug-resistance transporters
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Drug resistance in epilepsy: not futile, but complex?
1 reference
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Over-expression of P-glycoprotein in malformations of cortical development.
1 reference
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7 January 2021
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Pharmacogenetics of membrane transporters: an update on current approaches
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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P-glycoprotein activity and biological response.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Interaction of antiepileptic drugs with human P-glycoprotein in vitro
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The transport of antiepileptic drugs by P-glycoprotein
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
based on heuristic
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Regulation of the stability of P-glycoprotein by ubiquitination
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https://api.crossref.org/works/10.1016%2FS1734-1140%2812%2970900-3
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7 January 2021
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Identifiers
DOI
10.1016/S1734-1140(12)70900-3
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PubMed publication ID
23238460
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PubMed
ResearchGate publication ID
233914109
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