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Anthrax lethal and edema toxins in anthrax pathogenesis
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PubMed
title
Anthrax lethal and edema toxins in anthrax pathogenesis
(English)
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PubMed
main subject
pathogenesis
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based on heuristic
inferred from title
author
Stephen H. Leppla
series ordinal
3
object named as
Leppla SH
2 references
stated in
PubMed
PubMed ID
24684968
retrieved
25 November 2018
stated in
Crossref
Mahtab Moayeri
series ordinal
2
object named as
Mahtab Moayeri
1 reference
stated in
Crossref
Shihui Liu
series ordinal
1
object named as
Shihui Liu
1 reference
stated in
Crossref
language of work or name
English
1 reference
stated in
PubMed
publication date
June 2014
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stated in
PubMed
published in
Trends in Microbiology
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stated in
PubMed
volume
22
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stated in
PubMed
issue
6
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stated in
PubMed
page(s)
317-25
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stated in
PubMed
cites work
Raxibacumab
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
7 April 2017
Evidence against a human cell-specific role for LRP6 in anthrax toxin entry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
7 April 2017
The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
7 April 2017
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
7 April 2017
Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
7 April 2017
Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
7 April 2017
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor
1 reference
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PubMed Central
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retrieved
7 April 2017
Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
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7 April 2017
Bacillus anthracis edema factor substrate specificity: evidence for new modes of action
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
7 April 2017
Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity
1 reference
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PubMed Central
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7 April 2017
The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes
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PubMed Central
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7 April 2017
LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
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7 April 2017
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
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PubMed Central
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7 April 2017
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7 April 2017
Identification of the cellular receptor for anthrax toxin
1 reference
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7 April 2017
Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling
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7 April 2017
Vemurafenib: the first drug approved for BRAF-mutant cancer
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7 April 2017
Monoclonal antibody therapies against anthrax
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7 April 2017
The effects of anthrax lethal toxin on host barrier function
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7 April 2017
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
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7 April 2017
Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome
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7 April 2017
Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages
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7 April 2017
Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo
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7 April 2017
Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin
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28 September 2017
Circulating lethal toxin decreases the ability of neutrophils to respond to Bacillus anthracis
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28 September 2017
Deletion modification enhances anthrax specific immunity and protective efficacy of a hepatitis B core particle-based anthrax epitope vaccine
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Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions
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Key tissue targets responsible for anthrax-toxin-induced lethality
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Anthrax vaccines: present status and future prospects.
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28 September 2017
Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor
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28 September 2017
Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection
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28 September 2017
The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax
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28 September 2017
Cholera: pathophysiology and emerging therapeutic targets
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28 September 2017
A single-dose PLGA encapsulated protective antigen domain 4 nanoformulation protects mice against Bacillus anthracis spore challenge.
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Mutations in ANTXR1 cause GAPO syndrome.
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28 September 2017
B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model
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28 September 2017
Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A
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28 September 2017
Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity
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28 September 2017
Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors
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28 September 2017
The receptors that mediate the direct lethality of anthrax toxin
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Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1
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Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages
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Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax
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Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis
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28 September 2017
Novel approaches to the treatment of systemic anthrax
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28 September 2017
Updating perspectives on the initiation of Bacillus anthracis growth and dissemination through its host
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TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types
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28 September 2017
Binding and cell intoxication studies of anthrax lethal toxin
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28 September 2017
The dark sides of capillary morphogenesis gene 2.
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28 September 2017
Anthrax edema toxin impairs clearance in mice
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28 September 2017
Lipoprotein biosynthesis by prolipoprotein diacylglyceryl transferase is required for efficient spore germination and full virulence of Bacillus anthracis
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28 September 2017
Emergence of anthrax edema toxin as a master manipulator of macrophage and B cell functions
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28 September 2017
Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin
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28 September 2017
Noninvasive imaging technologies reveal edema toxin as a key virulence factor in anthrax
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28 September 2017
MEK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 melanoma cells.
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28 September 2017
Targeting the anthrax receptors, TEM-8 and CMG-2, for anti-angiogenic therapy
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28 September 2017
Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment
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Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice
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Recombinant anthrax toxin receptor-Fc fusion proteins produced in plants protect rabbits against inhalational anthrax
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28 September 2017
Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst
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28 September 2017
Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin
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28 September 2017
Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1
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Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b.
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28 September 2017
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28 September 2017
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Membrane translocation by anthrax toxin
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The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).
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28 September 2017
Mouse models of altered protein kinase A signaling
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28 September 2017
Anthrax toxin: pathologic effects on the cardiovascular system
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28 September 2017
Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature
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28 September 2017
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature
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Anthrax protective antigen cleavage and clearance from the blood of mice and rats
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Anthrax toxin: receptor binding, internalization, pore formation, and translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Manipulation of host signalling pathways by anthrax toxins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Anthrax toxins: A paradigm of bacterial immune suppression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Regulatory networks for virulence and persistence of Bacillus anthracis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
The alveolar macrophage: the Trojan horse of Bacillus anthracis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 September 2017
In vivo germination of Bacillus anthracis spores during murine cutaneous infection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 November 2018
Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 November 2018
Ratio of lethal and edema factors in rabbit systemic anthrax
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 November 2018
Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte-derived cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041834
retrieved
28 November 2018
cAMP Signaling by Anthrax Edema Toxin Induces Transendothelial Cell Tunnels, which Are Resealed by MIM via Arp2/3-Driven Actin Polymerization
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24684968
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24684968
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TIM.2014.02.012
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3138497
OpenCitations bibliographic resource ID
3138497
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3138497
PMCID
4041834
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3138497
PubMed ID
24684968
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3138497
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