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Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens
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scholarly article
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PubMed
review article
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PubMed
retrieved
23 October 2022
title
Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens
(English)
1 reference
stated in
PubMed
main subject
RNA interference
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based on heuristic
inferred from title
author
Amy H Buck
object named as
A. Buck
series ordinal
17
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John Stambas
object named as
J. Stambas
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7
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Iain Fraser
object named as
I. Fraser
series ordinal
11
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Musa Mhlanga
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12
object named as
M. Mhlanga
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Crossref
author name string
V. A. Meliopoulos
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1
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L. E. Andersen
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2
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K. F. Birrer
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3
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K. J. Simpson
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J. W. Lowenthal
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5
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A. G. D. Bean
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C. R. Stewart
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S. M. Tompkins
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9
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V. W. van Beusechem
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S. Barichievy
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Q. Smith
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D. Leake
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J. Karpilow
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G. Jona
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R. A. Tripp
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language of work or name
English
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PubMed
publication date
April 2012
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PubMed
1 April 2012
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PubMed Central
retrieved
23 October 2022
published in
FASEB Journal
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stated in
PubMed
stated in
PubMed Central
retrieved
23 October 2022
volume
26
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PubMed
issue
4
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stated in
PubMed
page(s)
1372-86
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PubMed
cites work
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Statistical methods for analysis of high-throughput RNA interference screens
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
NF-kappaB signaling differentially regulates influenza virus RNA synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Apoptosis leads to a degradation of vital components of active nuclear transport and a dissociation of the nuclear lamina
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Drosophila RNAi screen identifies host genes important for influenza virus replication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Host factors for replication and transcription of the influenza virus genome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Modifications in small interfering RNA that separate immunostimulation from RNA interference
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Emerging applications of network and pathway analysis in drug discovery and development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Increasing the robustness and validity of RNAi screens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Double-stranded regions are essential design components of potent inhibitors of RISC function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
RNA interference: from gene silencing to gene-specific therapeutics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Signalling by PI3K isoforms: insights from gene-targeted mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
RNA interference: the molecular immune system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Active NF-kappaB signalling is a prerequisite for influenza virus infection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
MEK inhibition impairs influenza B virus propagation without emergence of resistant variants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
The Ubiquitin‐Vacuolar Protein Sorting System is Selectively Required During Entry of Influenza Virus into Host Cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Caspase 3 activation is essential for efficient influenza virus propagation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Influenza-virus-induced signaling cascades: targets for antiviral therapy?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
MAP kinases in the immune response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Global impact of influenza virus on cellular pathways is mediated by both replication-dependent and -independent events
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Caspases disrupt the nuclear-cytoplasmic barrier
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Entry of influenza viruses into cells is inhibited by a highly specific protein kinase C inhibitor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
JNK2 and IKKbeta are required for activating the innate response to viral infection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 September 2017
The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
31 May 2018
Therapeutic applications of RNAi for silencing virus replication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
31 May 2018
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
31 May 2018
Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
31 May 2018
Distinct characteristics of heregulin signals mediated by HER3 or HER4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
31 May 2018
Increase in viral yield in eggs and MDCK cells of reassortant H5N1 vaccine candidate viruses caused by insertion of 38 amino acids into the NA stalk
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 November 2018
Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 November 2018
Characterization of the host cell entry of filamentous influenza virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 November 2018
Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 November 2018
Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 November 2018
Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3316894
retrieved
28 November 2018
Effects of protein kinase C inhibitors on viral entry and infectivity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22247330
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
2'-O-methyl-modified RNAs act as TLR7 antagonists
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22247330
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Signaling through protein kinase C
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22247330
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1096/FJ.11-193466
0 references
Fatcat ID
release_ahllkqcofjdntlvgcbxkud6kle
0 references
PMCID
3316894
1 reference
stated in
PubMed
PubMed ID
22247330
1 reference
stated in
PubMed
ResearchGate publication ID
221749584
0 references
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