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New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors
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scholarly article
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title
New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors
(English)
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PubMed
main subject
G protein-coupled receptor
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protein design
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author name string
K. A. Jacobson
series ordinal
1
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S. Costanzi
series ordinal
2
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Crossref
language of work or name
English
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PubMed
publication date
September 2012
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PubMed
published in
Molecular Pharmacology
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PubMed
volume
82
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PubMed
issue
3
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PubMed
page(s)
361-71
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PubMed
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422707
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28 September 2017
Structure-based discovery of beta2-adrenergic receptor ligands
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422707
retrieved
28 September 2017
Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422707
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28 September 2017
On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422707
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28 September 2017
A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422707
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28 September 2017
Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening
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PubMed Central
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28 September 2017
Local peptide movement in the photoreaction intermediate of rhodopsin
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PubMed Central
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28 September 2017
A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator
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PubMed Central
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28 September 2017
Crystallographic analysis of primary visual photochemistry
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422707
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28 September 2017
Structure of bovine rhodopsin in a trigonal crystal form.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422707
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28 September 2017
Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors
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28 September 2017
Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.
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28 September 2017
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
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31 May 2018
Identification of novel adenosine A(2A) receptor antagonists by virtual screening.
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31 May 2018
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment
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31 May 2018
Use of the X-ray structure of the beta2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds
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28 November 2018
Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422707
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28 November 2018
The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
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PubMed Central
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28 November 2018
Identifiers
DOI
10.1124/MOL.112.079335
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Fatcat ID
release_bey24gcs4bdgdpsoqbmdpbgxui
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PMC publication ID
3422707
1 reference
stated in
PubMed
PubMed publication ID
22695719
1 reference
stated in
PubMed
ResearchGate publication ID
225307130
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