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The role of transporters in toxicity and disease
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title
The role of transporters in toxicity and disease
(English)
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author name string
J. D. Schuetz
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1
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P. W. Swaan
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2
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D. J. Tweedie
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3
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language of work or name
English
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publication date
April 2014
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published in
Drug Metabolism and Disposition
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volume
42
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issue
4
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page(s)
541-5
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cites work
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Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump
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Regulation of the function of the human ABCG2 multidrug transporter by cholesterol and bile acids: effects of mutations in potential substrate and steroid binding sites
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Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.
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In vitro methods to support transporter evaluation in drug discovery and development
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Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry
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Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties
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The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel
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28 September 2017
Organic anion transporter (Slc22a) family members as mediators of toxicity
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Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.
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Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance
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Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.
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28 November 2018
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28 November 2018
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28 November 2018
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28 November 2018
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28 November 2018
Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice
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28 November 2018
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).
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28 November 2018
A perspective on the contribution of metabolites to drug-drug interaction potential: the need to consider both circulating levels and inhibition potency
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retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24598705
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice
1 reference
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reference URL
https://pubmed.ncbi.nlm.nih.gov/24598705
retrieved
12 December 2020
based on heuristic
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Identifiers
DOI
10.1124/DMD.114.057539
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3754232
OpenCitations bibliographic resource ID
3754232
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3754232
PMC publication ID
3965901
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3754232
PubMed publication ID
24598705
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3754232
ResearchGate publication ID
260562457
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