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Synthetic biology of antimicrobial discovery
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scholarly article
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PubMed
title
Synthetic biology of antimicrobial discovery
(English)
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main subject
synthetic biology
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based on heuristic
inferred from title
author name string
Bijan Zakeri
series ordinal
1
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stated in
Crossref
Timothy K. Lu
series ordinal
2
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
19 July 2013
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stated in
PubMed
published in
ACS Synthetic Biology
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stated in
Crossref
volume
2
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stated in
PubMed
issue
7
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stated in
PubMed
page(s)
358-72
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stated in
PubMed
cites work
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Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes
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Bacteriophage lysins as effective antibacterials
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In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides
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Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance
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Crystal Structure of the Minor Pilin FctB Reveals Determinants of Group A Streptococcal Pilus Anchoring
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Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics
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Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure
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Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.
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The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
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Isopeptide bonds block the mechanical extension of pili in pathogenic Streptococcus pyogenes
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The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification
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Chemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.
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A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains
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28 September 2017
Renaissance in antibacterial discovery from actinomycetes
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Yeast surface display for protein engineering and characterization
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Expanding the metabolic engineering toolbox: more options to engineer cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Selection of single domain binding proteins by covalent DNA display
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28 September 2017
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis
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28 September 2017
A singular enzymatic megacomplex from Bacillus subtilis
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28 September 2017
Molecular engineering approaches to peptide, polyketide and other antibiotics
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28 September 2017
Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis.
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28 September 2017
Pili with strong attachments: Gram-positive bacteria do it differently
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28 September 2017
Genetics of Streptomyces rimosus, the oxytetracycline producer.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Cell-penetrating peptides and antimicrobial peptides: how different are they?
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Protein splicing in cis and in trans
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action
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28 September 2017
The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria.
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28 September 2017
Sampling the antibiotic resistome
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28 September 2017
Phage display systems and their applications
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Biofilms and antibiotic therapy: is there a role for combating bacterial resistance by the use of novel drug delivery systems?
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Synthesis of (-)-tetracycline
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Bioactive microbial metabolites
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Glycopeptide and lipoglycopeptide antibiotics
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Binding Affinities of Host–Guest, Protein–Ligand, and Protein–Transition‐State Complexes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Vancomycin assembly: nature's way.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Genetic engineering using homologous recombination
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
The pyocins of Pseudomonas aeruginosa
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Combinatorial biosynthesis of antibiotics: challenges and opportunities
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Improved activity of a synthetic indolicidin analog.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Subtiligase: a tool for semisynthesis of proteins
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Classics in infectious diseases: on the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae by Alexander Fleming, Reprinted from the British Journal of Experimental Pathology [...]
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 September 2017
A system for the continuous directed evolution of biomolecules
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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31 May 2018
Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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31 May 2018
The role of carbohydrates in biologically active natural products
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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31 May 2018
Molecular requirements for the inhibition of the tetracycline antiport protein and the effect of potent inhibitors on the growth of tetracycline-resistant bacteria.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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31 May 2018
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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31 May 2018
Modular organization of genes required for complex polyketide biosynthesis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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31 May 2018
Turning a new phage
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Antibiotic resistance is ancient: implications for drug discovery
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
DNA construction: homemade or ordered out?
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Coupling molecular dynamics simulations with experiments for the rational design of indolicidin-analogous antimicrobial peptides
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Identification of OxyE as an ancillary oxygenase during tetracycline biosynthesis.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
An engineered R-type pyocin is a highly specific and sensitive bactericidal agent for the food-borne pathogen Escherichia coli O157:H7.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Rational design and assembly of synthetic trimodular polyketide synthases.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Antibacterial discovery and development--the failure of success?
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
retrieved
28 November 2018
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Experimental evolution of resistance to an antimicrobial peptide.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Inhibition of daptomycin by pulmonary surfactant: in vitro modeling and clinical impact
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
BIOSYNTHESIS OF THE TETRACYCLINES. 8. CHARACTERIZATION OF 4-HYDROXY-6-METHYLPRETETRAMID.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Biosynthesis of the tetracyclines. IX. 4-Aminodedimethylaminoanhydrodemethylchlortetracycline from a mutant of Streptomyces aureofaciens
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716841
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28 November 2018
Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/23654251
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
4-Dedimethylamino-4-epiamino-5a,6-anhydrotetracycline
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23654251
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
BIOSYNTHESIS OF THE TETRACYCLINES. VII. 4-HYDROXY-6-METHYLPRETETRAMID, AN INTERMEDIATE ACCUMULATED BY A BLOCKED MUTANT OF STREPTOMYCES AUREOFACIENS
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23654251
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Biosynthesis of the tetracyclines. XII. Anhydrodemethylchlortetracycline from a mutant of Streptomyces aureofaciens
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23654251
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1021/SB300101G
0 references
PMC publication ID
3716841
1 reference
stated in
PubMed
PubMed publication ID
23654251
1 reference
stated in
PubMed
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