(Q37968899)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22173434%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Designing antimicrobial peptides: form follows function (English)

1 reference

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18 January 2020

main subject

antimicrobial peptide

1 reference

Erratum: Designing antimicrobial peptides: form follows function

inferred from title

corrigendum / erratum

0 references

author

Christopher Fjell

series ordinal

1

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18 January 2020

Jan Alexander Hiss

series ordinal

2

1 reference

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18 January 2020

Gisbert Schneider

series ordinal

4

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18 January 2020

3

Robert E W Hancock

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18 January 2020

publication date

16 December 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22173434%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

18 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22173434%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

11

1 reference

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18 January 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22173434%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

37-51

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https://scigraph.springernature.com/pub.10.1038/nrd3591

18 January 2020

exact match

0 references

cites work

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Antibacterial peptides: basic facts and emerging concepts

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Antibiotic peptides as mediators of innate immunity

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31 March 2020

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Clinical efficacy of a specifically targeted antimicrobial peptide mouth rinse: targeted elimination of Streptococcus mutans and prevention of demineralization

31 March 2020

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Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater

31 March 2020

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The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils

31 March 2020

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Antimicrobial peptide hLF1-11 directs granulocyte-macrophage colony-stimulating factor-driven monocyte differentiation toward macrophages with enhanced recognition and clearance of pathogens

31 March 2020

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Cathelicidins: a family of endogenous antimicrobial peptides

31 March 2020

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Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations.

31 March 2020

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Multifunctional cationic host defence peptides and their clinical applications

31 March 2020

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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?

31 March 2020

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Antibiotic proteins of human neutrophils

31 March 2020

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Synthesis of the antibacterial peptide cecropin A (1-33).

31 March 2020

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Antimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity

31 March 2020

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Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I.

31 March 2020

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Identification of a new member of the protegrin family by cDNA cloning

31 March 2020

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The role of defensins in lung biology and therapy

31 March 2020

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Interaction of polyphemusin I and structural analogs with bacterial membranes, lipopolysaccharide, and lipid monolayers

31 March 2020

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A multinational, randomized phase III trial of iseganan HCl oral solution for reducing the severity of oral mucositis in patients receiving radiotherapy for head-and-neck malignancy.

31 March 2020

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A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia

31 March 2020

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Cationic peptides: a new source of antibiotics

31 March 2020

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Extreme antimicrobial Peptide and polymyxin B resistance in the genus burkholderia

31 March 2020

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Peptide promiscuity: an evolutionary concept for plant defense.

31 March 2020

1 reference

Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation.

31 March 2020

1 reference

Antibiotics as probes of biological complexity

31 March 2020

1 reference

How to cope with the quest for new antibiotics.

31 March 2020

1 reference

Structure and mechanism of action of an indolicidin peptide derivative with improved activity against gram-positive bacteria

31 March 2020

1 reference

The co-evolution of host cationic antimicrobial peptides and microbial resistance

31 March 2020

1 reference

Experimental evolution of resistance to an antimicrobial peptide.

31 March 2020

1 reference

How many drug targets are there?

31 March 2020

1 reference

31 March 2020

1 reference

Molecular complexity and fragment-based drug discovery: ten years on.

31 March 2020

1 reference

Chemogenomic approaches to rational drug design

31 March 2020

1 reference

Compound library design for target families

31 March 2020

1 reference

Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.

31 March 2020

1 reference

Gaussian interaction profile kernels for predicting drug-target interaction.

31 March 2020

1 reference

Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides

31 March 2020

1 reference

A lipocentric view of peptide-induced pores.

31 March 2020

1 reference

Antimicrobial peptides: successes, challenges and unanswered questions

31 March 2020

1 reference

Label-free detection of melittin binding to a membrane using electrochemical-localized surface plasmon resonance

31 March 2020

1 reference

Bacterial membrane lipids in the action of antimicrobial agents

31 March 2020

1 reference

Lipid headgroup discrimination by antimicrobial peptide LL-37: insight into mechanism of action

31 March 2020

1 reference

Impact of LL-37 on anti-infective immunity.

31 March 2020

1 reference

Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells.

31 March 2020

1 reference

Intracellular receptor for human host defense peptide LL-37 in monocytes

31 March 2020

1 reference

Homeodomain-derived peptides. In and out of the cells

31 March 2020

1 reference

De novo generation of short antimicrobial peptides with simple amino acid composition

31 March 2020

1 reference

Cellular uptake of Antennapedia Penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation

31 March 2020

1 reference

Cell-free immunity in insects

31 March 2020

1 reference

N-terminal analogues of cecropin A: synthesis, antibacterial activity, and conformational properties.

31 March 2020

1 reference

The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis.

31 March 2020

1 reference

Cell-penetrating peptides: mechanisms and applications

31 March 2020

1 reference

Diversity of antimicrobial peptides and their mechanisms of action

31 March 2020

1 reference

The relationship between peptide structure and antibacterial activity

31 March 2020

1 reference

AMPer: a database and an automated discovery tool for antimicrobial peptides.

31 March 2020

1 reference

Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genome

31 March 2020

1 reference

CAMP: a useful resource for research on antimicrobial peptides

31 March 2020

1 reference

Prediction of antimicrobial peptides based on sequence alignment and feature selection methods

31 March 2020

1 reference

ANTIMIC: a database of antimicrobial sequences

31 March 2020

1 reference

Current trends in antimicrobial agent research: chemo- and bioinformatics approaches

31 March 2020

1 reference

APD: the Antimicrobial Peptide Database

31 March 2020

1 reference

APD2: the updated antimicrobial peptide database and its application in peptide design

31 March 2020

1 reference

Overview on plant antimicrobial peptides.

31 March 2020

1 reference

Antibacterials from the sea.

31 March 2020

1 reference

Computational methods for calculation of ligand-binding affinity.

31 March 2020

1 reference

31 March 2020

Drug-binding databases

1 reference

Hit finding: towards 'smarter' approaches

31 March 2020

1 reference

Computational design of highly selective antimicrobial peptides.

31 March 2020

1 reference

Knowledge-based computational methods for identifying or designing novel, non-homologous antimicrobial peptides

31 March 2020

1 reference

Protein epitope mimetics as anti-infectives

31 March 2020

1 reference

Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents

31 March 2020

1 reference

Alpha-helical cationic antimicrobial peptides: relationships of structure and function

31 March 2020

1 reference

Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an alpha-helical 'sequence template'

31 March 2020

1 reference

Exploring and profiling protein function with peptide arrays

31 March 2020

1 reference

High-throughput generation of small antibacterial peptides with improved activity

31 March 2020

1 reference

Sequence Requirements and an Optimization Strategy for Short Antimicrobial Peptides

31 March 2020

1 reference

A linguistic model for the rational design of antimicrobial peptides.

31 March 2020

1 reference

Design of model amphipathic peptides having potent antimicrobial activities

31 March 2020

1 reference

De novo generation of cationic antimicrobial peptides: influence of length and tryptophan substitution on antimicrobial activity

31 March 2020

1 reference

De novo design of potent antimicrobial peptides

31 March 2020

1 reference

Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity.

31 March 2020

1 reference

Rational design of α-helical antimicrobial peptides to target Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa: utilization of charge, 'specificity determinants,' total hydrophobicity, hydrophobe type and location as desig

31 March 2020

1 reference

Design and activity of a 'dual-targeted' antimicrobial peptide

31 March 2020

1 reference

De novo design of molecular architectures by evolutionary assembly of drug-derived building blocks

31 March 2020

1 reference

BREED: Generating novel inhibitors through hybridization of known ligands. Application to CDK2, p38, and HIV protease.

31 March 2020

1 reference

Effects of acyl versus aminoacyl conjugation on the properties of antimicrobial peptides

31 March 2020

1 reference

Antibacterial activity of ultrashort cationic lipo-beta-peptides

31 March 2020

1 reference

A new group of antifungal and antibacterial lipopeptides derived from non-membrane active peptides conjugated to palmitic acid

31 March 2020

1 reference

Computer simulation of antimicrobial peptides

31 March 2020

1 reference

Efficient drug lead discovery and optimization

31 March 2020

1 reference

Computer-based de novo design of drug-like molecules

31 March 2020

1 reference

Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide.

31 March 2020

1 reference

Structure-based design of an indolicidin peptide analogue with increased protease stability

31 March 2020

1 reference

Computational studies of protegrin antimicrobial peptides: a review.

31 March 2020

1 reference

Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes

31 March 2020

1 reference

Antimicrobial and cell-penetrating peptides: structure, assembly and mechanisms of membrane lysis via atomistic and coarse-grained molecular dynamics simulations.

31 March 2020

1 reference

Biophysical properties of membrane-active peptides based on micelle modeling: a case study of cell-penetrating and antimicrobial peptides

31 March 2020

1 reference

Membrane binding of an acyl-lactoferricin B antimicrobial peptide from solid-state NMR experiments and molecular dynamics simulations

31 March 2020

1 reference

Toroidal pores formed by antimicrobial peptides show significant disorder.

31 March 2020

1 reference

Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR.

31 March 2020

1 reference

Molecular dynamics simulations of helical antimicrobial peptides in SDS micelles: what do point mutations achieve?

31 March 2020

1 reference

Coupling molecular dynamics simulations with experiments for the rational design of indolicidin-analogous antimicrobial peptides

31 March 2020

1 reference

Phage display: concept, innovations, applications and future

31 March 2020

1 reference

Basic overview of chemoinformatics

31 March 2020

1 reference

Artificial neural networks for computer-based molecular design.

31 March 2020

1 reference

Computational approaches to therapeutic peptide discovery

31 March 2020

1 reference

Concepts and applications of "natural computing" techniques in de novo drug and peptide design.

31 March 2020

1 reference

A multiobjective evolutionary method for the design of peptidic mimotopes.

31 March 2020

1 reference

Evolutionary computation and multimodal search: a good combination to tackle molecular diversity in the field of peptide design.

31 March 2020

1 reference

31 March 2020

Evolutionary computation

1 reference

Adaptive combinatorial design of focused compound libraries

31 March 2020

1 reference

31 March 2020

1 reference

Voyages to the (un)known: adaptive design of bioactive compounds

31 March 2020

1 reference

The importance of discerning shape in molecular pharmacology

31 March 2020

1 reference

Application of QSAR and shape pharmacophore modeling approaches for targeted chemical library design

31 March 2020

1 reference

Peptide quantitative structure-activity relationships, a multivariate approach.

31 March 2020

1 reference

Antibiotic activity of pentadecapeptides modelled from amino acid descriptors

31 March 2020

1 reference

Prediction of antibiotic activity and synthesis of new pentadecapeptides based on lactoferricins

31 March 2020

1 reference

Increased antibacterial activity of 15-residue murine lactoferricin derivatives

31 March 2020

1 reference

Modelling of anti-HSV activity of lactoferricin analogues using amino acid descriptors

31 March 2020

1 reference

QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides derived from protegrin-1.

31 March 2020

1 reference

Protegrin structure-activity relationships: using homology models of synthetic sequences to determine structural characteristics important for activity.

31 March 2020

1 reference

Variable selection methods in QSAR: an overview.

31 March 2020

1 reference

Descriptors for antimicrobial peptides

31 March 2020

1 reference

Past and future perspectives of synthetic peptide libraries

31 March 2020

1 reference

Describing the mechanism of antimicrobial peptide action with the interfacial activity model

31 March 2020

1 reference

Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes

31 March 2020

1 reference

Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs

31 March 2020

1 reference

Identification of novel antibacterial peptides by chemoinformatics and machine learning

31 March 2020

1 reference

Optimization of antibacterial peptides by genetic algorithms and cheminformatics

31 March 2020

1 reference

Antibiotics in the clinical pipeline in 2011.

31 March 2020

1 reference

Safety and tolerability of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11)

31 March 2020

1 reference

A phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy.

31 March 2020

1 reference

Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream

31 March 2020

1 reference

Tethering antimicrobial peptides: current status and potential challenges

31 March 2020

1 reference

Screening and Characterization of Surface-Tethered Cationic Peptides for Antimicrobial Activity

31 March 2020

1 reference

ADMET in silico modelling: towards prediction paradise?

31 March 2020

1 reference

Chemoinformatics and library design

31 March 2020

1 reference

An evaluation of peptide-bond isosteres

31 March 2020

1 reference

Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents

31 March 2020

1 reference

A novel approach to the pulmonary delivery of liposomes in dry powder form to eliminate the deleterious effects of milling

31 March 2020

1 reference

Properties and structure-activity studies of cyclic beta-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I.

31 March 2020

1 reference

In silico prediction of ADMET properties: how far have we come?

31 March 2020

1 reference

In silico toxicology for the pharmaceutical sciences

31 March 2020

1 reference

Multiobjective optimization of combinatorial libraries

31 March 2020

1 reference

New directions in library design and analysis

31 March 2020

1 reference

Multi-dimensional QSAR in drug discovery

31 March 2020

1 reference

Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.

31 March 2020

1 reference

De novo drug design using multiobjective evolutionary graphs.

31 March 2020

1 reference

31 March 2020

1 reference

In silico pharmacology for drug discovery: applications to targets and beyond

31 March 2020

1 reference

Advances in methods for therapeutic peptide discovery, design and development

31 March 2020

1 reference

Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics

31 March 2020

1 reference

Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention

31 March 2020

1 reference

Control of cell selectivity of antimicrobial peptides

31 March 2020

1 reference

Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity

31 March 2020

1 reference

Structural Framework for the Modulation of the Activity of the Hybrid Antibiotic Peptide Cecropin A-Melittin [CA(1-7)M(2-9)] by Nε-Lysine Trimethylation

31 March 2020

1 reference

The generation of antimicrobial peptide activity: a trade-off between charge and aggregation?

31 March 2020

1 reference

Lipid complexes with cationic peptides and OAKs; their role in antimicrobial action and in the delivery of antimicrobial agents

31 March 2020

1 reference

Simultaneous observation of peptide backbone lipid solvation and α-helical structure by deep-UV resonance Raman spectroscopy

31 March 2020

1 reference

A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs

31 March 2020

1 reference

Cationic antimicrobial peptides: towards clinical applications

31 March 2020

1 reference

Genomics, systems biology and drug development for infectious diseases

31 March 2020

1 reference

The rational design of amino acid sequences by artificial neural networks and simulated molecular evolution: de novo design of an idealized leader peptidase cleavage site

31 March 2020

1 reference

Molecular mechanism of antimicrobial peptides: the origin of cooperativity

31 March 2020

1 reference

31 March 2020

The Protein Data Bank

1 reference

Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation

31 March 2020

1 reference

Scalable molecular dynamics with NAMD

31 March 2020

1 reference

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

31 March 2020

1 reference

Amylases in the Human Vagina

31 March 2020

1 reference

Analysis of amino acid indices and mutation matrices for sequence comparison and structure prediction of proteins

31 March 2020

1 reference

Stochastic Proximity Embedding: Methods and Applications.

31 March 2020

1 reference

Neighborhood-Preserving Visualization of Adaptive Structure-Activity Landscapes: Application to Drug Discovery

31 March 2020

1 reference

Peptide design aided by neural networks: biological activity of artificial signal peptidase I cleavage sites.

31 March 2020

1 reference

Peptide design by artificial neural networks and computer-based evolutionary search

31 March 2020

1 reference

ENPDA: an evolutionary structure-based de novo peptide design algorithm.

31 March 2020

1 reference

In silico panning for a non-competitive peptide inhibitor

31 March 2020

1 reference

A novel knowledge-based approach to design inorganic-binding peptides

31 March 2020

1 reference

Design of MHC I stabilizing peptides by agent-based exploration of sequence space

31 March 2020

1 reference

Evolutionary Pareto-optimization of stably folding peptides

31 March 2020

1 reference

Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection

31 March 2020

1 reference

RDP58 is a novel and potentially effective oral therapy for ulcerative colitis.

31 March 2020

1 reference

Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II.

31 March 2020

1 reference

Artificial neural networks and simulated molecular evolution are potential tools for sequence-oriented protein design.

31 March 2020

1 reference

12 December 2020

New strategies for novel antibiotics: peptides targeting bacterial cell membranes

1 reference

12 December 2020

RAPD: a database of recombinantly-produced antimicrobial peptides

1 reference

12 December 2020

Feature selection in quantitative structure-activity relationships.

1 reference

12 December 2020

Computational toxicology approaches at the US Food and Drug Administration

1 reference

12 December 2020

Development of simple fitness landscapes for peptides by artificial neural filter systems.

1 reference

12 December 2020

Virtual screening and fast automated docking methods.

1 reference

12 December 2020

Antimicrobial peptide resistance mechanisms of human bacterial pathogens.

1 reference

12 December 2020

The role of cathelicidins in the innate host defenses of mammals.

1 reference

12 December 2020

Antimicrobial factors of normal tissues and fluids.

1 reference

12 December 2020

Inducible expression of an antimicrobial peptide of the innate immunity in polymorphonuclear leukocytes.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3591

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22173434%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference