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FBW7-mediated ubiquitination and degradation of KLF5
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PubMed
title
FBW7-mediated ubiquitination and degradation of KLF5
(English)
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main subject
protein ubiquitination
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based on heuristic
inferred from title
author name string
Luan Y
series ordinal
1
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stated in
PubMed
Wang P
series ordinal
2
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stated in
PubMed
language of work or name
English
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stated in
PubMed
publication date
26 May 2014
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stated in
PubMed
published in
World journal of biological chemistry
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volume
5
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stated in
PubMed
issue
2
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stated in
PubMed
page(s)
216-23
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stated in
PubMed
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Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer
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Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
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FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development
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A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α).
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F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.
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The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator
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Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
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SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.
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The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein
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28 September 2017
Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice
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Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells
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The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation
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The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs
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Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1.
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Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases
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SUMOylation regulates nuclear localization of Krüppel-like factor 5.
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KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells
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Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.
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The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114
retrieved
28 November 2018
FBXW7/hCDC4 is a general tumor suppressor in human cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114
retrieved
28 November 2018
Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114
retrieved
28 November 2018
Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114
retrieved
28 November 2018
Fbxw7 hotspot mutations and human colon cancer: mechanistic insights from new mouse models
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24921010
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24921010
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Klf5 is involved in self-renewal of mouse embryonic stem cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24921010
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
PMCID
4050114
1 reference
stated in
PubMed
PubMed ID
24921010
1 reference
stated in
PubMed
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