(Q27322930)

English

Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer

scientific article (publication date: 2011)

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scholarly article

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Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer (English)

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hepatocellular carcinoma

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based on heuristic

inferred from title

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inferred from title

Gregory Michelotti

object named as

Gregory A Michelotti

14

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author name string

George M Philips

1

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Isaac S Chan

2

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Marzena Swiderska

3

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Vanessa T Schroder

4

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Cynthia Guy

5

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Gamze F Karaca

6

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Cynthia Moylan

7

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Talaignair Venkatraman

8

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Sebastian Feuerlein

9

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Wing-Kin Syn

10

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Youngmi Jung

11

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Rafal P Witek

12

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Steve Choi

13

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Fatima Rangwala

15

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Elmar Merkle

16

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Christopher Lascola

17

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Anna Mae Diehl

18

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language of work or name

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publication date

2011

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6

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9

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e23943

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copyright license

Creative Commons Attribution 4.0 International

2 September 2011

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April 2022 Public Data File from Crossref

copyright status

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Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

21 March 2017

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

1 reference

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21 March 2017

Role of multidrug resistance 3 deficiency in pediatric and adult liver disease: one gene for three diseases

1 reference

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21 March 2017

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

21 March 2017

Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

21 March 2017

Influence of bile salts on hepatic mdr2 P-glycoprotein expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

21 March 2017

Hedgehog signals regulate multiple aspects of gastrointestinal development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

21 March 2017

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

7 April 2017

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

7 April 2017

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Increased production of sonic hedgehog by ballooned hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Hepatocellular carcinoma: current management and perspectives for the future

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Hedgehog signaling in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Signals from dying hepatocytes trigger growth of liver progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

CD44, a therapeutic target for metastasising tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Liver diseases related to MDR3 (ABCB4) gene deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Liver cirrhosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Sinusoidal remodeling and angiogenesis: a new function for the liver-specific pericyte?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Hedgehog signaling maintains resident hepatic progenitors throughout life

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Role for hedgehog signaling in hepatic stellate cell activation and viability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Cancer stem cells: repair gone awry?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

28 September 2017

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

31 May 2018

Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

31 May 2018

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

31 May 2018

Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166282

31 May 2018

Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Molecular mechanisms of liver carcinogenesis in the mdr2-knockout mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Activation of the hedgehog pathway in human hepatocellular carcinomas.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Hedgehog signaling in human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Osteopontin combined with CD44, a novel prognostic biomarker for patients with hepatocellular carcinoma undergoing curative resection

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023943

21 January 2018

Expression of CD44 in human hepatocellular carcinoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21912653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog-mediated mesenchymal–epithelial interactions modulate hepatic response to bile duct ligation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21912653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21912653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteopontin: A missing link between hedgehog signaling and fibrosis in nonalcoholic steatohepatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21912653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0023943

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2011PLoSO...623943P

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release_2ir3qaj5mvdebhxh7tdz2dqxy4

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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