(Q27548667)

English

Gcn1p YGL195W

fungal protein found in Saccharomyces cerevisiae S288c

GCN1
YGL195W
Gcn1p

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

10 December 2016

Translational activator Gcn1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33892

Armadillo-like helical

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33892

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33892

Gcn1, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TOG domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HEAT, type 2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

9 references

9 May 2019

Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Evidence that Yih1 resides in a complex with ribosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

translation initiation factor binding

determination method

1 reference

9 May 2019

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

ATP-dependent protein binding

determination method

1 reference

9 May 2019

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

ribosome binding

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

cytosolic ribosome

determination method

1 reference

9 May 2019

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

determination method

1 reference

9 May 2019

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

determination method

polysomal ribosome

determination method

3 references

9 May 2019

Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

biological process

cellular response to stress

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33892&geneProductId=UniProtKB:P33892

determination method

regulation of translational elongation

determination method

1 reference

9 May 2019

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

positive regulation of protein phosphorylation

determination method

3 references

9 May 2019

Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

cellular response to amino acid starvation

determination method

4 references

9 May 2019

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

regulation of protein kinase activity

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

cellular response to hydrogen peroxide

determination method

1 reference

9 May 2019

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

positive regulation of translational initiation in response to starvation

determination method

2 references

9 May 2019

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

9 May 2019

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

cellular response to benomyl

determination method

1 reference

9 May 2019

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

cellular stress response to acidic pH

determination method

1 reference

9 May 2019

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

positive regulation of macroautophagy

determination method

1 reference

9 May 2019

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

negative regulation of TORC1 signaling

determination method

1 reference

9 May 2019

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33892

determination method

Gcn1, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33892

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33892

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33892

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Saccharomyces Genome Database ID

1 reference

20 March 2022

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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