(Q42427957)

English

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

scientific article published on 5 January 2017

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scholarly article

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Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae (English)

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Serine/threonine-protein kinase GCN2 YDR283C

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

based on heuristic

inferred from title

Saccharomyces cerevisiae

1 reference

based on heuristic

inferred from title

author name string

Wenjie Yuan

1

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Shuguang Guo

2

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Jiaoqi Gao

3

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Mingming Zhong

4

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Gonghong Yan

5

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Wangmeng Wu

6

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Yapeng Chao

7

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Yu Jiang

8

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

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publication date

5 January 2017

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

292

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

7

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

2660-2669

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Amino acid signalling upstream of mTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

The eIF2α kinases: their structures and functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Leucyl-tRNA synthetase: double duty in amino acid sensing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

The TOR complex 1 is a direct target of Rho1 GTPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Leucyl-tRNA synthetase controls TORC1 via the EGO complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Nutritional control of cell growth via TOR signaling in budding yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Amino acid signaling in TOR activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

The Vam6 GEF controls TORC1 by activating the EGO complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Molecular mechanisms of mTOR-mediated translational control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Biochemical methods to monitor autophagy-related processes in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Translational responses to growth factors and stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

mTOR signaling: RAG GTPases transmit the amino acid signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

TOR signaling and S6 kinase 1: Yeast catches up.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Rapamycin activates Tap42-associated phosphatases by abrogating their association with Tor complex 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

TOR signaling in growth and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

The TOR and EGO protein complexes orchestrate microautophagy in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

The Role of Phosphatases in TOR Signaling in Yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Regulation of translation initiation by amino acids in eukaryotic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Translational control during amino acid starvation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

5 June 2018

Control of the translational machinery by amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

16 August 2018

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

16 August 2018

Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

16 August 2018

Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

16 August 2018

Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314164

16 August 2018

Structure of TOR and Its Complex with KOG1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.772194

21 January 2018

Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/28057755

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28057755

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M116.772194

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

release_azkdvpguergtdmlhf2lniha2da

1 reference

https://api.fatcat.wiki/v0/release/azkdvpguergtdmlhf2lniha2da

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 June 2018

http://europepmc.org/abstract/PMC/5314164

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