(Q27640311)

3

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Milton T Stubbs

object named as

Milton T Stubbs

7

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author name string

Sabine Reyda

1

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Christian Sohn

2

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Kathrin Rall

4

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Dirk Ullmann

5

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Hans Dieter Jakubke

Journal of Molecular Biology

6

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language of work or name

English

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publication date

31 January 2003

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published in

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volume

325

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page(s)

963-77

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issue

5

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cites work

Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids

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High-throughput three-dimensional protein structure determination.

7 January 2021

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Synthetic inhibitors of thrombin and factor Xa: from bench to bedside

7 January 2021

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Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design

7 January 2021

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Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety

7 January 2021

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Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position

7 January 2021

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Structure of human des(1-45) factor Xa at 2.2 A resolution

7 January 2021

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X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

7 January 2021

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Structural basis for chemical inhibition of human blood coagulation factor Xa

7 January 2021

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Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa

7 January 2021

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Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors

7 January 2021

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Crystal structures of human factor Xa complexed with potent inhibitors

7 January 2021

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Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

7 January 2021

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Design of benzamidine-type inhibitors of factor Xa

7 January 2021

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Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.

7 January 2021

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Rational design, synthesis, and biological activity of benzoxazinones as novel factor Xa inhibitors

7 January 2021

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Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors

7 January 2021

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Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

7 January 2021

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Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies

7 January 2021

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Converting trypsin to chymotrypsin: the role of surface loops

7 January 2021

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Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants

7 January 2021

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New enzyme lineages by subdomain shuffling

7 January 2021

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Relocating a negative charge in the binding pocket of trypsin

7 January 2021

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Enzymatic coupling of specific peptides at nonspecific ligation sites: effect of Asp189Glu mutation in trypsin on substrate mimetic-mediated reactions

7 January 2021

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A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues

7 January 2021

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Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases

7 January 2021

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Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

7 January 2021

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Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

7 January 2021

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Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator

7 January 2021

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The use of composite crystal-field environments in molecular recognition and the de novo design of protein ligands

7 January 2021

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Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

7 January 2021

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(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.

7 January 2021

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Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enz

7 January 2021

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The Na+ binding site of thrombin

7 January 2021

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The coagulation cascade: initiation, maintenance, and regulation

7 January 2021

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Haemophilia B: database of point mutations and short additions and deletions, fifth edition, 1994.

7 January 2021

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X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

7 January 2021

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Surface loop 199-204 in blood coagulation factor IX is a cofactor-dependent site involved in macromolecular substrate interaction

7 January 2021

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Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity

7 January 2021

1 reference

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Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa

7 January 2021

1 reference

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Substitution of asparagine for arginine 347 of recombinant factor Xa markedly reduces factor Va binding

7 January 2021

1 reference

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Definition of a factor Va binding site in factor Xa.

7 January 2021

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Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

7 January 2021

1 reference

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Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity.

7 January 2021

1 reference

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Substitution of aspartic acid for methionine-306 in factor VIIa abolishes the allosteric linkage between the active site and the binding interface with tissue factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

7 January 2021

1 reference

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Structure of human factor VIIa and its implications for the triggering of blood coagulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Probing inhibitor-induced conformational changes along the interface between tissue factor and factor VIIa.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

The factor VII zymogen structure reveals reregistration of beta strands during activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

The mechanism of activation of human plasminogen by streptokinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Crystal structure of the catalytic domain of human plasmin complexed with streptokinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Human plasminogen catalytic domain undergoes an unusual conformational change upon activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Crystal structure of the proenzyme domain of plasminogen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Structural basis of the activation and action of trypsin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Enzymatic properties of the one- and two-chain form of tissue plasminogen activator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-tryp

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Protein structure modeling for structural genomics.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Synthetic inhibitors of bovine factor Xa and thrombin comparison of their anticoagulant efficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

The graphical determination of Km and Ki

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Processing of X-ray diffraction data collected in oscillation mode

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

Improved methods for building protein models in electron density maps and the location of errors in these models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2901337-2

10.1016/S0022-2836(02)01337-2

7 January 2021

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

619779

OpenCitations bibliographic resource ID

619779

1 reference