(Q27641154)

1

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Susan Arent

2

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Olof Björnberg

3

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Mette Ottosen

4

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Kaj Frank Jensen

6

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Sine Larsen

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

1 August 2003

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published in

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volume

278

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issue

31

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page(s)

28812-22

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cites work

The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase

1 reference

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Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans.

21 January 2018

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Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

21 January 2018

1 reference

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Sequence analysis and identification of the pyrKDbF operon from Lactococcus lactis including a novel gene, pyrK, involved in pyrimidine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

The B form of dihydroorotate dehydrogenase from Lactococcus lactis consists of two different subunits, encoded by the pyrDb and pyrK genes, and contains FMN, FAD, and [FeS] redox centers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Analysis of the kinetic mechanism of the bovine liver mitochondrial dihydroorotate dehydrogenase

21 January 2018

1 reference

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Mechanistic studies with deuterated dihydroorotates on the dihydroorotate oxidase from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303767200

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303767200

Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

1 reference

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Automated refinement of protein models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

RASMOL: biomolecular graphics for all

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Raster3D: photorealistic molecular graphics

21 January 2018

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Flavoenzymes: diverse catalysts with recurrent features

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Histidine to alanine mutants of human dihydroorotate dehydrogenase. Identification of a brequinar-resistant mutant enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Redoxal as a new lead structure for dihydroorotate dehydrogenase inhibitors: a kinetic study of the inhibition mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

Structure of Dihydroorotate Dehydrogenase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200

On the treatment of negative intensity observations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303767200