(Q27651104)

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The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

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scholarly article

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The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change (English)

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Joseph A. Beavo

4

object named as

Joseph A Beavo

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author name string

Sergio E Martinez

1

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Clemens C Heikaus

2

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Rachel E Klevit

3

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language of work or name

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publication date

19 September 2008

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Journal of Biological Chemistry

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283

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25913-9

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38

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Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Intrinsically disordered -subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

NMR View: A computer program for the visualization and analysis of NMR data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Developments in the CCP4 molecular-graphics project

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Maximum-likelihood density modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Automated MAD and MIR structure solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

20 March 2017

Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

7 April 2017

The CCP4 molecular-graphics project

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

7 April 2017

Backbone dynamics of Escherichia coli ribonuclease HI: correlations with structure and function in an active enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

7 April 2017

Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

Properties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

Binding of cGMP to GAF domains in amphibian rod photoreceptor cGMP phosphodiesterase (PDE). Identification of GAF domains in PDE alphabeta subunits and distinct domains in the PDE gamma subunit involved in stimulation of cGMP binding to GAF domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

G proteins and phototransduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

The GAF domain: an evolutionary link between diverse phototransducing proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

Visual transduction in vertebrate rods and cones: a tale of two transmitters, calcium and cyclic GMP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533791

29 September 2017

A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802891200

21 January 2018

[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802891200

21 January 2018

The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structure.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802891200

21 January 2018

Direct interaction of the inhibitory gamma-subunit of Rod cGMP phosphodiesterase (PDE6) with the PDE6 GAFa domains.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802891200

21 January 2018

Molecular determinants of cGMP binding to chicken cone photoreceptor phosphodiesterase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802891200

21 January 2018

Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802891200

21 January 2018

Molecular organization of bovine rod cGMP-phosphodiesterase 6.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802891200

21 January 2018

The GAFa domains of rod cGMP-phosphodiesterase 6 determine the selectivity of the enzyme dimerization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802891200

21 January 2018

The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802891200

21 January 2018

Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614542

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subunit structure of rod cGMP-phosphodiesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614542

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614542

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614542

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a bovine cone photoreceptor phosphodiesterase purified by cyclic GMP-sepharose chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614542

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural determinants of the PDE6 GAF A domain for binding the inhibitory gamma-subunit and noncatalytic cGMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614542

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A subset of GAF domains are evolutionarily conserved sodium sensors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614542

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M802891200

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