(Q27654261)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19309137%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19309137%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

0 references

2

1 reference

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24 January 2020

Rey-Ting Guo

5

1 reference

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24 January 2020

Kilannin Krysiak

6

1 reference

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24 January 2020

20

Andrew H-J Wang

1 reference

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24 January 2020

24

Eric Oldfield

1 reference

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24 January 2020

author name string

Yonghui Zhang

1

1 reference

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24 January 2020

Fenglin Yin

3

1 reference

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24 January 2020

Michael P Hudock

4

1 reference

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24 January 2020

Sujoy Mukherjee

7

1 reference

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24 January 2020

Yi-Gui Gao

8

1 reference

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24 January 2020

Howard Robinson

9

1 reference

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24 January 2020

Yongcheng Song

10

1 reference

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24 January 2020

Joo Hwan No

11

1 reference

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24 January 2020

Kyle Bergan

12

1 reference

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24 January 2020

Annette Leon

13

1 reference

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24 January 2020

Lauren Cass

14

1 reference

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24 January 2020

Amanda Goddard

15

1 reference

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24 January 2020

Ting-Kai Chang

16

1 reference

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24 January 2020

Fu-Yang Lin

17

1 reference

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24 January 2020

Ermond Van Beek

18

1 reference

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24 January 2020

Socrates Papapoulos

19

1 reference

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24 January 2020

Tadahiko Kubo

21

1 reference

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24 January 2020

Mitsuo Ochi

22

1 reference

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24 January 2020

Dushyant Mukkamala

23

1 reference

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24 January 2020

language of work or name

English

0 references

publication date

1 April 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19309137%20AND%20SRC:MED&resulttype=core&format=json

Journal of the American Chemical Society

24 January 2020

published in

1 reference

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24 January 2020

volume

131

1 reference

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24 January 2020

issue

14

1 reference

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24 January 2020

page(s)

5153-5162

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19309137%20AND%20SRC:MED&resulttype=core&format=json

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

24 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

SHELXL: high-resolution refinement

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Coot: model-building tools for molecular graphics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Bisphosphonates and cancer-induced bone disease: beyond their antiresorptive activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Bisphosphonates: preclinical review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Adaptive immune response of Vγ2Vδ2 T cells: a new paradigm

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Relationship between physicochemical and osteotropic properties of bisphosphonic derivatives: rational design for osteotropic drug delivery system (ODDS).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753403

27 November 2018

1 reference

12 December 2020

Zoledronic acid-induced IPP/ApppI production in vivo

1 reference

12 December 2020

Bisphosphonates in cancer therapy

1 reference

12 December 2020

Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA808285E

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19309137%20AND%20SRC:MED&resulttype=core&format=json

release_yza4syjhgralzbsft362nlndxq

24 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yza4syjhgralzbsft362nlndxq

24 November 2022

mapped directly with Wikidata item

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19309137%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

19309137

2 references