(Q27657973)

6

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Nicolas Winssinger

object named as

Nicolas Winssinger

8

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Len Neckers

7

object named as

Len Neckers

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author name string

Sofia Barluenga

1

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Jean-Gonzague Fontaine

2

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Cuihua Wang

3

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Kais Aouadi

4

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Ruihong Chen

SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers

5

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language of work or name

1 reference

23 November 2009

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published in

ChemBioChem

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volume

10

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issue

17

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page(s)

2753-9

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cites work

1 reference

12 December 2020

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents

1 reference

12 December 2020

Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update

1 reference

12 December 2020

Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues

1 reference

12 December 2020

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

1 reference

12 December 2020

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol

1 reference

12 December 2020

Diversity-oriented synthesis of pochonins and biological evaluation against a panel of kinases

1 reference

12 December 2020

Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.

1 reference

12 December 2020

Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors

1 reference

12 December 2020

Discovery and development of purine-scaffold Hsp90 inhibitors

1 reference

12 December 2020

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

1 reference

12 December 2020

HSP90 and the chaperoning of cancer

1 reference

12 December 2020

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

1 reference

12 December 2020

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

1 reference

12 December 2020

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

1 reference

12 December 2020

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

1 reference

12 December 2020

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

1 reference

12 December 2020

Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation

1 reference

12 December 2020

Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

1 reference

12 December 2020

Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor

1 reference

12 December 2020

Intrinsic inhibition of the Hsp90 ATPase activity

1 reference

12 December 2020

Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms

1 reference

12 December 2020

The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts

1 reference

12 December 2020

Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol

1 reference

12 December 2020

Discovery and development of heat shock protein 90 inhibitors

1 reference

12 December 2020

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

1 reference

12 December 2020

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

1 reference

12 December 2020

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

12 December 2020

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

1 reference

12 December 2020

Discovery and development of pyrazole-scaffold Hsp90 inhibitors

1 reference

12 December 2020

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

1 reference

12 December 2020

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

1 reference

12 December 2020

Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

1 reference

12 December 2020

Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study

1 reference

12 December 2020

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

1 reference

12 December 2020

Targeting Hsp90: small-molecule inhibitors and their clinical development

1 reference

12 December 2020

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

1 reference

12 December 2020

Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

1 reference

12 December 2020

Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands

1 reference

12 December 2020

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

1 reference

12 December 2020

Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?

1 reference

12 December 2020

Pharmacological prevention of Parkinson disease in Drosophila.

1 reference

12 December 2020

Identifiers

DOI

10.1002/CBIC.200900494

1 reference

Consolidated OpenCitations Corpus – April 2017

4402568

4402568

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference