(Q27666020)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21095570%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21095570%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

0 references

0 references

0 references

Clostridium difficile

0 references

author

Aimee Shen

7

1 reference

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16 January 2020

6

Matthew Bogyo

1 reference

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16 January 2020

author name string

Aaron W Puri

1

1 reference

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16 January 2020

Patrick J Lupardus

2

1 reference

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16 January 2020

Edgar Deu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21095570%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Victoria E Albrow

4

1 reference

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16 January 2020

K Christopher Garcia

5

1 reference

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16 January 2020

publication date

1 November 2010

1 reference

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16 January 2020

published in

Chemistry and Biology

1 reference

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16 January 2020

volume

17

1 reference

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16 January 2020

issue

11

1 reference

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16 January 2020

page(s)

1201-1211

1 reference

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describes a project that uses

16 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3005307/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing in Clostridium difficile Toxin A

20 March 2017

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20 March 2017

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Toxin B is essential for virulence of Clostridium difficile

7 April 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Automated protein model building combined with iterative structure refinement

20 March 2017

1 reference

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20 March 2017

1 reference

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Autoprocessing of the Vibrio cholerae RTX toxin by the cysteine protease domain

20 March 2017

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Clostridium difficile infection: new developments in epidemiology and pathogenesis

20 March 2017

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Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins

7 April 2017

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Structural organization of the functional domains of Clostridium difficile toxins A and B

29 September 2017

1 reference

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Allosteric regulation of protease activity by small molecules.

29 September 2017

1 reference

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Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors

29 September 2017

1 reference

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Using small molecules to dissect mechanisms of microbial pathogenesis

29 September 2017

1 reference

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Bacterial toxins: an overview on bacterial proteases and their action as virulence factors

29 September 2017

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Positional scanning synthetic combinatorial libraries for substrate profiling

29 September 2017

1 reference

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Trapping moving targets with small molecules

29 September 2017

1 reference

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Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium

29 September 2017

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Clostridium difficile--more difficult than ever

29 September 2017

1 reference

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Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells

29 September 2017

1 reference

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Processing of Clostridium difficile toxins

29 September 2017

1 reference

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29 September 2017

1 reference

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Current and future treatment modalities for Clostridium difficile-associated disease

29 September 2017

1 reference

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Clostridium difficile toxins: more than mere inhibitors of Rho proteins

29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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Cellular uptake of Clostridium difficile toxin B. Translocation of the N-terminal catalytic domain into the cytosol of eukaryotic cells

29 September 2017

1 reference

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Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells

29 September 2017

1 reference

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Drug-like properties and the causes of poor solubility and poor permeability

29 September 2017

1 reference

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Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005307

Glucosylation of Rho proteins by Clostridium difficile toxin B.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005307

Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005307

Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005307

Viral proteases: evolution of diverse structural motifs to optimize function

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005307

Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005307

Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005307

The complete receptor-binding domain of Clostridium difficile toxin A is required for endocytosis

27 November 2018

1 reference

12 December 2020

Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity

1 reference

12 December 2020

Purification of a functional receptor for Clostridium difficile toxin A from intestinal brush border membranes of infant hamsters

1 reference

12 December 2020

Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones

1 reference

12 December 2020

10.1016/J.CHEMBIOL.2010.09.011

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21095570%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21095570%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

21095570

1 reference