(Q27676497)

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Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

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Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation (English)

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digestive enzyme

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based on heuristic

inferred from title

Evette S. Radisky

6

object named as

Evette S Radisky

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Alexei S Soares

4

object named as

Alexei S Soares

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author name string

Jyotica Batra

1

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András Szabó

2

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Thomas R Caulfield

3

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Miklós Sahin-Tóth

5

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publication date

5 April 2013

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Journal of Biological Chemistry

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288

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14

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9848-59

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Chymotrypsin C mutations in chronic pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

A clogged gutter mechanism for protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Comparison of anionic and cationic trypsinogens: The anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Structure of bovine trypsinogen at 1.9 Å resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Likelihood-enhanced fast translation functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

ARP/wARP and molecular replacement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Automated protein model building combined with iterative structure refinement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

On the size of the active site in proteases. I. Papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

20 March 2017

Very fast empirical prediction and rationalization of protein pKa values

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

7 April 2017

Serine protease mechanism and specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

7 April 2017

Structural basis of substrate specificity in the serine proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

7 April 2017

Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Energetic analysis of fragment docking and application to structure-based pharmacophore hypothesis generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Fundamental aspects of protein-protein association kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Serine peptidases: classification, structure and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Crystal and molecular structure of chymotrypsin inhibitor 2 from barley seeds in complex with subtilisin Novo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Anchor residues in protein-protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Canonical protein inhibitors of serine proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

The role of the protein core in the inhibitory power of the classic serine protease inhibitor, chymotrypsin inhibitor 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Role of charged residues in the catalytic mechanism of hepatitis C virus NS3 protease: electrostatic precollision guidance and transition-state stabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Natural protein proteinase inhibitors and their interaction with proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

29 September 2017

Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

2 June 2018

Refined 1.2 A crystal structure of the complex formed between subtilisin Carlsberg and the inhibitor eglin c. Molecular structure of eglin and its detailed interaction with subtilisin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

2 June 2018

Influence of proline residues on protein conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

2 June 2018

Changing the inhibitory specificity and function of the proteinase inhibitor eglin c by site-directed mutagenesis: functional and structural investigation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

2 June 2018

Isolation and characterisation of a low molecular weight inhibitor (of chymotrypsin and human granulocytic elastase and cathepsin G) from leeches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617285

2 June 2018

Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Crystal and molecular structure of the bovine α-chymotrypsin-eglin c complex at 2.0 Å resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKa Values.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Motion of transfer RNA from the A/T state into the A-site using docking and simulations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Purification, cDNA cloning, and recombinant expression of chymotrypsin C from porcine pancreas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Mechanism of charge compensation and impairment of co-operative functions in haemoglobin Tacoma (Arg B12(30)β → ser)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Proline cis-trans isomerization and protein folding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Conformational energies and configurational statistics of copolypeptides containing l-proline

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Complementarity of Structure Ensembles in Protein-Protein Binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Structural Factors Contributing to the Hydrophobic Effect: The Partly Exposed Hydrophobic Minicore in Chymotrypsin Inhibitor 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.457382

21 January 2018

Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disulfide-linked propeptides stabilize the structure of zymogen and mature pancreatic serine proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A detailed structural comparison between the charge relay system in chymotrypsinogen and in alpha-chymotrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel method for generating structure-based pharmacophores using energetic analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dynamics simulations of human DNA methyltransferase 3B with selective inhibitor nanaomycin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal and molecular structure of the inhibitor eglin from leeches in complex with subtilisin Carlsberg

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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