(Q27679062)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

0 references

8

1 reference

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5 March 2020

7

Nouri Neamati

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

Yanbin Ji

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Subhabrata Majumder

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Melissa Millard

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Radhika Borra

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Tao Bi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Ahmed Y Elnagar

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Julio A Camarero

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

language of work or name

English

0 references

publication date

25 July 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

Journal of the American Chemical Society

5 March 2020

published in

1 reference

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5 March 2020

volume

135

1 reference

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5 March 2020

issue

31

1 reference

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5 March 2020

page(s)

11623-11633

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX Interactions

5 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Apamin as a novel template for structure-based rational design of potent peptide activators of p53

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

MDMX: a novel p53-binding protein with some functional properties of MDM2

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Regulation of p53 stability by Mdm2

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Synthesis of proteins by native chemical ligation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Participation of p53 protein in the cellular response to DNA damage

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Biological synthesis of circular polypeptides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Small-molecule inhibitors of p53-MDM2 interaction: the 2006-2010 update.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Awakening guardian angels: drugging the p53 pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Cyclotides as templates in drug design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Cytoplasmic functions of the tumour suppressor p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Turning a scorpion toxin into an antitumor miniprotein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Analysis of the MDM2 antagonist nutlin-3 in human prostate cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

The P53 pathway: what questions remain to be explored?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Profiling bladder cancer using targeted antibody arrays

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

p53 oncogene mutations in three human prostate cancer cell lines

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767463

Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53

27 November 2018

1 reference

12 December 2020

Miniature protein inhibitors of the p53-hDM2 interaction

1 reference

12 December 2020

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

1 reference

12 December 2020

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

1 reference

12 December 2020

Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA405108P

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23848581%20AND%20SRC:MED&resulttype=core&format=json