(Q27683611)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Squalene synthase as a target for Chagas disease therapeutics (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

0 references

0 references

1 reference

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

Dolores Gonzalez-Pacanowska

17 March 2020

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Rey-Ting Guo

24

1 reference

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17 March 2020

19

Andrew H-J Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

3

Tzu-Ping Ko

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

17

Wanderley de Souza

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

23

Eric Oldfield

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

author name string

Na Shang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Qian Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Hsiu-Chien Chan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Jikun Li

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Yingying Zheng

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Chun-Hsiang Huang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Feifei Ren

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Chun-Chi Chen

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Zhen Zhu

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Melina Galizzi

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Zhu-Hong Li

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Carlos A Rodrigues-Poveda

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Phercyles Veiga-Santos

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Tecia Maria Ulisses de Carvalho

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Julio A Urbina

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Kai Li

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Yi-Liang Liu

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

language of work or name

English

0 references

publication date

1 May 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

page(s)

e1004114

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

17 March 2020

copyright license

start time

1 May 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Chemo-Immunotherapeutic Antimalarials Targeting Isoprenoid Biosynthesis

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Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets

20 March 2017

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Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

20 March 2017

1 reference

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Mechanism of action and inhibition of dehydrosqualene synthase

20 March 2017

1 reference

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Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

20 March 2017

1 reference

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A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

20 March 2017

1 reference

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Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis

20 March 2017

1 reference

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Protein structure prediction on the Web: a case study using the Phyre server

20 March 2017

1 reference

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Version 1.2 of the Crystallography and NMR system

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

20 March 2017

1 reference

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Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs

20 March 2017

1 reference

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Global economic burden of Chagas disease: a computational simulation model

20 March 2017

1 reference

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Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents

29 September 2017

1 reference

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Leishmaniasis: prevention, parasite detection and treatment

29 September 2017

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The V-ATPase as a target for antifungal drugs

29 September 2017

1 reference

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Terpene biosynthesis: modularity rules

29 September 2017

1 reference

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Targeting isoprenoid biosynthesis for drug discovery: bench to bedside

29 September 2017

1 reference

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Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators

29 September 2017

1 reference

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Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006925

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006925

In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi

29 September 2017

1 reference

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Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006925

Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006925

Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.

29 September 2017

1 reference

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1-Hydroxy-3-(methylpentylamino)-propylidene-1,1-bisphosphonic acid as a potent inhibitor of squalene synthase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006925

Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease

29 September 2017

1 reference

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Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method

29 September 2017

1 reference

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A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems

29 September 2017

1 reference

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Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease.

29 September 2017

1 reference

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Trinuclear Metal Clusters in Catalysis by Terpenoid Synthases

2 June 2018

1 reference

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Thermodynamics of bisphosphonates binding to human bone: a two-site model

2 June 2018

1 reference

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Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus

2 June 2018

1 reference

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In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006925

Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives

2 June 2018

1 reference

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Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006925

Chagas disease: pushing through the pipeline

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004114

Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004114

Structural insights into the catalytic mechanism of human squalene synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004114

Geometric characteristics of hydrogen bonds involving sulfur atoms in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004114

A solanesyl-diphosphate synthase localizes in glycosomes of Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004114

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004114

Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004114

Preparation and antimycotic properties of derivatives of 1-phenethylimidazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004114

Trial renews interest in Chagas' disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006925

Isotopes incorporated in the Nucleic Acids of Trypanosoma mega

27 November 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004114

Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24789335

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24789335

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24789335

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PPAT.1004114

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

24789335

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789335%20AND%20SRC:MED&resulttype=core&format=json