(Q27677853)

English

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

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scholarly article

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Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity (English)

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12

object named as

Eric Oldfield

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author name string

Joo Hwan No

1

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Fernando de Macedo Dossin

2

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Yonghui Zhang

3

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Yi-Liang Liu

4

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Wei Zhu

5

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Xinxin Feng

6

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Jinyoung Anny Yoo

7

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Eunhae Lee

8

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Ke Wang

9

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Raymond Hui

10

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Lucio H Freitas-Junior

11

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language of work or name

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publication date

13 March 2012

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Proceedings of the National Academy of Sciences of the United States of America

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109

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11

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4058-63

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Mechanism of action and inhibition of dehydrosqualene synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

Artemisinin resistance: current status and scenarios for containment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus : In Vitro, in Vivo, and Crystallographic Results †

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation †

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

20 March 2017

Carotenoid biosynthesis in intraerythrocytic stages of Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

24 May 2017

The relationship between the chemistry and biological activity of the bisphosphonates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

Intraerythrocytic stages of Plasmodium falciparum biosynthesize menaquinone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

Quinuclidine derivatives as potential antiparasitics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

Pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica: molecular cloning, recombinant expression and inhibition by pyrophosphate analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

29 September 2017

Thermodynamics of bisphosphonates binding to human bone: a two-site model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

2 June 2018

Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

2 June 2018

Protein prenyl transferase activities of Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306666

2 June 2018

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1118215109

21 January 2018

Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1118215109

21 January 2018

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1118215109

21 January 2018

Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1118215109

21 January 2018

(31)P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1118215109

21 January 2018

NMR investigations of the static and dynamic structures of bisphosphonates on human bone: a molecular model

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1118215109

21 January 2018

Activity of bisphosphonates against Trypanosoma brucei rhodesiense

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1118215109

21 January 2018

Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1118215109

21 January 2018

Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1118215109

21 January 2018

Electrospray ionization mass spectrometry analysis of polyisoprenoid alcohols via Li+ cationization

1 reference

https://pubmed.ncbi.nlm.nih.gov/22392982

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1118215109

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2012PNAS..109.4058N

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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ResearchGate publication ID

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