(Q27683710)

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Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 June 2017

Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

structural biology

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object named as

Ludmila Leroy

3

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Allen M Orville

object named as

Allen M Orville

13

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Alexei S Soares

15

object named as

Alexei S Soares

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Europe PubMed Central

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25 June 2017

author name string

Xingyu Yin

1

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Europe PubMed Central

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25 June 2017

Alexander Scalia

2

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Europe PubMed Central

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25 June 2017

Christina M Cuttitta

4

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25 June 2017

Gina M Polizzo

5

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Europe PubMed Central

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25 June 2017

Daniel L Ericson

6

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Europe PubMed Central

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25 June 2017

Christian G Roessler

7

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Europe PubMed Central

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25 June 2017

Olven Campos

8

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Europe PubMed Central

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25 June 2017

Millie Y Ma

9

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Europe PubMed Central

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25 June 2017

Rakhi Agarwal

10

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25 June 2017

Rick Jackimowicz

11

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Europe PubMed Central

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25 June 2017

Marc Allaire

12

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25 June 2017

Robert M Sweet

14

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25 June 2017

publication date

30 April 2014

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Europe PubMed Central

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25 June 2017

Acta Crystallographica Section D: Biological Crystallography

1 reference

Europe PubMed Central

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25 June 2017

70

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Europe PubMed Central

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25 June 2017

Pt 5

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Europe PubMed Central

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25 June 2017

1177-1189

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Europe PubMed Central

PubMed publication ID

25 June 2017

Missing Fragments: Detecting Cooperative Binding in Fragment-Based Drug Design

1 reference

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20 March 2017

On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin

1 reference

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Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening

1 reference

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CrystalDirect: a new method for automated crystal harvesting based on laser-induced photoablation of thin films

1 reference

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Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy

1 reference

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20 March 2017

Macro-to-Micro Structural Proteomics: Native Source Proteins for High-Throughput Crystallization

1 reference

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Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance Raman, and UV-visible spectroscopic analysis of a Rieske-type demethylase

1 reference

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The DINGO dataset: a comprehensive set of data for the SAMPL challenge

1 reference

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From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1)

1 reference

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Acoustically mounted microcrystals yield high-resolution X-ray structures.

1 reference

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Towards a restriction proteinase: construction of a self-activating enzyme

1 reference

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Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors

1 reference

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Molecular Shape and Medicinal Chemistry: A Perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

20 March 2017

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

20 March 2017

Characterization of the CHK1 allosteric inhibitor binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

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Operator-assisted harvesting of protein crystals using a universal micromanipulation robot

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

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Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency

1 reference

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Understanding binding selectivity toward trypsin and factor Xa: the role of aromatic interactions

1 reference

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Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

20 March 2017

Real-space refinement of the structure of hen egg-white lysozyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

20 March 2017

REFMAC5 for the refinement of macromolecular crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

20 March 2017

Overview of the CCP4 suite and current developments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

20 March 2017

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

20 March 2017

ARP/wARP and molecular replacement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

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Bioactive contaminants leach from disposable laboratory plasticware

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

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Acoustic methods for high-throughput protein crystal mounting at next-generation macromolecular crystallographic beamlines

1 reference

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1 reference

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Nanolitre-scale crystallization using acoustic liquid-transfer technology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

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Fragment screening purely with protein crystallography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014116

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From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance

1 reference

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1 reference

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Fragment approaches in structure-based drug discovery

1 reference

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29 September 2017

SPR-based fragment screening: advantages and applications

1 reference

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Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets.

1 reference

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1 reference

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1 reference

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1 reference

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Advanced beamline automation for biological crystallography experiments.

1 reference

https://api.crossref.org/works/10.1107%2FS1399004713034603

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Fragment-Based Drug Discovery

1 reference

https://api.crossref.org/works/10.1107%2FS1399004713034603

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ChemSpider: An Online Chemical Information Resource

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https://api.crossref.org/works/10.1107%2FS1399004713034603

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12 December 2020

based on heuristic

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The influence of lead discovery strategies on the properties of drug candidates

1 reference

https://pubmed.ncbi.nlm.nih.gov/24816088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implementing surface plasmon resonance biosensors in drug discovery

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https://pubmed.ncbi.nlm.nih.gov/24816088

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A molecular clip with allosteric binding properties

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4 June 2024

https://opencitations.net/index/api/v1/citations/10.1021/JA00017A063

Identifiers

10.1107/S1399004713034603

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 June 2017

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