(Q27684590)

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Susceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with Peptide

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Susceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with Peptide (English)

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Marek Wieczorek

4

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author name string

Liusong Yin

1

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Peter Trenh

2

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Abigail Guce

3

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Sascha Lange

5

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Jana Sticht

6

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Wei Jiang

7

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Marissa Bylsma

8

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Elizabeth D Mellins

9

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Christian Freund

10

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Lawrence J Stern

11

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publication date

22 August 2014

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Journal of Biological Chemistry

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289

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34

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23449-64

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Disruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

Peptide linkage to the α-subunit of MHCII creates a stably inverted antigen presentation complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

Bidirectional binding of invariant chain peptides to an MHC class II molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

The CCPN data model for NMR spectroscopy: development of a software pipeline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

Editing of the HLA-DR-peptide repertoire by HLA-DM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

20 March 2017

The role of dynamic conformational ensembles in biomolecular recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

7 April 2017

A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

HLA-DM: arbiter conformationis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Conformational variation in structures of classical and non-classical MHCII proteins and functional implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

FoXS: a web server for rapid computation and fitting of SAXS profiles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Model for the peptide-free conformation of class II MHC proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

HLA-DM negatively regulates HLA-DR4-restricted collagen pathogenic peptide presentation and T cell recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Point Mutations in or Near the Antigen-Binding Groove of HLA-DR3 Implicate Class II-Associated Invariant Chain Peptide Affinity as a Constraint on MHC Class II Polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Distinct recognition by two subsets of T cells of an MHC class II-peptide complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

DM determines the cryptic and immunodominant fate of T cell epitopes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Aberrant intermolecular disulfide bonding in a mutant HLA-DM molecule: implications for assembly, maturation, and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Human monoclonal antibody with T-cell-like specificity recognizes MHC class I self-peptide presented by HLA-DR1 on activated cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

29 September 2017

A Peptide/MHCII conformer generated in the presence of exchange peptide is substrate for HLA-DM editing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

2 June 2018

T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

2 June 2018

Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

2 June 2018

Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

2 June 2018

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

2 June 2018

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

2 June 2018

The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4156084

2 June 2018

Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

Structural factors contributing to DM susceptibility of MHC class II/peptide complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

Indirect recognition of T-cell epitopes derived from the alpha 3 and transmembrane domain of HLA-A2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

Empty and peptide-loaded class II major histocompatibility complex proteins produced by expression in Escherichia coli and folding in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

Small-angle scattering studies of biological macromolecules in solution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

An insertion mutant in DQA1*0501 restores susceptibility to HLA-DM: implications for disease associations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

PRIMUS: a Windows PC-based system for small-angle scattering data analysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

Looking behind the Beamstop: X-Ray Solution Scattering Studies of Structure and Conformational Changes of Biological Macromolecules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.585539

21 January 2018

T Lymphocyte Responses to Nonpolymorphic HLA-Derived Peptides Are Associated With Chronic Renal Allograft Dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/25002586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperativity during the formation of peptide/MHC class II complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25002586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conformational change in the human major histocompatibility complex protein HLA-DR1 induced by peptide binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/25002586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/25002586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HLA-DRα chain residues located on the outer loops are involved in nonpolymorphic and polymorphic antibody-binding epitopes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25002586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A three-step kinetic mechanism for peptide binding to MHC class II proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25002586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR

1 reference

https://pubmed.ncbi.nlm.nih.gov/25002586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance

1 reference

https://pubmed.ncbi.nlm.nih.gov/25002586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperativity of hydrophobic anchor interactions: evidence for epitope selection by MHC class II as a folding process

1 reference

https://pubmed.ncbi.nlm.nih.gov/25002586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.585539

1 reference

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1 reference

Consolidated OpenCitations Corpus – April 2017

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1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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