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Defects in mitochondrial metabolism and cancer
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stated in
PubMed
title
Defects in mitochondrial metabolism and cancer
(English)
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stated in
PubMed
main subject
mitochondrion
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based on heuristic
inferred from title
author
Christian Frezza
object named as
Christian Frezza
series ordinal
2
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author name string
Edoardo Gaude
series ordinal
1
1 reference
stated in
Crossref
publication date
17 July 2014
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stated in
PubMed
published in
Cancer & Metabolism
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stated in
Crossref
volume
2
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PubMed
page(s)
10
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stated in
PubMed
exact match
https://scigraph.springernature.com/pub.10.1186/2049-3002-2-10
0 references
cites work
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Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
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20 March 2017
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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Recurring mutations found by sequencing an acute myeloid leukemia genome
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20 March 2017
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
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20 March 2017
The consensus coding sequences of human breast and colorectal cancers
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20 March 2017
On the Origin of Cancer Cells
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Dimers of mitochondrial ATP synthase form the permeability transition pore
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20 March 2017
Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2
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20 March 2017
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
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20 March 2017
Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion
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20 March 2017
IDH mutation impairs histone demethylation and results in a block to cell differentiation
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Mitochondria and cancer
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
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7 April 2017
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
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7 April 2017
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability
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7 April 2017
Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes
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7 April 2017
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
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7 April 2017
The hydrogen hypothesis for the first eukaryote
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7 April 2017
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.
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29 September 2017
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.
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29 September 2017
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
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29 September 2017
Metabolism addiction in pancreatic cancer
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29 September 2017
Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma
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29 September 2017
Isocitrate dehydrogenase 2 mutation is a frequent event in osteosarcoma detected by a multi-specific monoclonal antibody MsMab-1.
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29 September 2017
The role of mitochondria in the oncogenic signal transduction
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29 September 2017
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
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29 September 2017
Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells.
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29 September 2017
Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells
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29 September 2017
Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment
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29 September 2017
Succinate dehydrogenase expression in breast cancer.
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29 September 2017
Succinate: a new epigenetic hacker
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29 September 2017
The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.
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29 September 2017
Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells.
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29 September 2017
Suppression of mitochondrial complex I influences cell metastatic properties
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29 September 2017
Decreased expression of the mitochondrial metabolic enzyme aconitase (ACO2) is associated with poor prognosis in gastric cancer
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Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor
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29 September 2017
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency
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29 September 2017
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
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29 September 2017
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29 September 2017
Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.
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29 September 2017
Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth
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29 September 2017
Mitochondria as sensors and regulators of calcium signalling
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29 September 2017
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
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29 September 2017
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
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29 September 2017
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
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29 September 2017
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling
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29 September 2017
Impaired OXPHOS complex III in breast cancer
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29 September 2017
Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas
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29 September 2017
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29 September 2017
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations
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29 September 2017
Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2
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29 September 2017
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
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29 September 2017
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29 September 2017
Forced cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells.
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29 September 2017
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29 September 2017
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29 September 2017
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis
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29 September 2017
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29 September 2017
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29 September 2017
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29 September 2017
Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
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29 September 2017
mtDNA mutations increase tumorigenicity in prostate cancer
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29 September 2017
Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hürthle cell tumors
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29 September 2017
Origin and evolution of eukaryotic apoptosis: the bacterial connection
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29 September 2017
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
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Somatic mutations of the mitochondrial genome in human colorectal tumours
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29 September 2017
Citrate as an in vivo marker to discriminate prostate cancer from benign prostatic hyperplasia and normal prostate peripheral zone: detection via localized proton spectroscopy
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29 September 2017
Symbiotic theory of the origin of eukaryotic organelles; criteria for proof
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
29 September 2017
Diminished tumorigenic phenotype after depletion of mitochondrial DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
2 June 2018
Active oxidative decarboxylation of malate by mitochondria isolated from L-1210 ascites tumor cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
2 June 2018
Sodium, potassium, calcium, magnesium, zinc, citrate and chloride content of human prostatic and seminal fluid.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
2 June 2018
Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
SDH mutations establish a hypermethylator phenotype in paraganglioma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
Enhanced citrate synthase activity in human pancreatic cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
Cooperation and competition in the evolution of ATP-producing pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108232
retrieved
27 November 2018
High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25057353
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mitochondrial diseases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25057353
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1186/2049-3002-2-10
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2548559
Dimensions Publication ID
1019627735
0 references
OpenCitations bibliographic resource ID
2548559
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2548559
PMCID
4108232
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2548559
PubMed ID
25057353
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2548559
ResearchGate publication ID
264201577
0 references
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