(Q27704228)

GOA release 2020-03-11

1 reference

10

Christopher J Winrow

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Chad A Brautigam

3

object named as

Chad A Brautigam

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author name string

Jie Yin

1

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Kerim Babaoglu

2

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Lindsay Clark

4

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Zhenhua Shao

5

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Thomas H Scheuermann

6

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Charles M Harrell

7

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Anthony L Gotter

8

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Anthony J Roecker

9

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John J Renger

11

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Paul J Coleman

12

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Daniel M Rosenbaum

Nature Structural & Molecular Biology

13

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publication date

April 2016

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published in

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volume

23

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issue

4

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page(s)

293-9

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cites work

The hypocretins/orexins: integrators of multiple physiological functions

1 reference

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

20 April 2017

1 reference

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

20 April 2017

1 reference

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

20 April 2017

1 reference

Role of lateral hypothalamic orexin neurons in reward processing and addiction

20 April 2017

1 reference

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

20 April 2017

1 reference

Structure of the agonist-bound neurotensin receptor

20 April 2017

1 reference

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

20 April 2017

1 reference

Crystal structure of rhodopsin: A G protein-coupled receptor

20 April 2017

1 reference

Crystal structure of a lipid G protein-coupled receptor

20 April 2017

1 reference

Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor

20 April 2017

1 reference

Study of Human Orexin-1 and -2 G-Protein-Coupled Receptors with Novel and Published Antagonists by Modeling, Molecular Dynamics Simulations, and Site-Directed Mutagenesis

20 April 2017

1 reference

Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B

20 April 2017

1 reference

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

20 April 2017

1 reference

Structure of the δ-opioid receptor bound to naltrindole

20 April 2017

1 reference

Linking Crystallographic Model and Data Quality

20 April 2017

1 reference

Phasercrystallographic software

20 April 2017

1 reference

PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 April 2017

1 reference

Features and development of Coot

20 April 2017

1 reference

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

20 April 2017

1 reference

MolProbity: all-atom structure validation for macromolecular crystallography

20 April 2017

1 reference

Environment and exposure to solvent of protein atoms. Lysozyme and insulin

20 April 2017

1 reference

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

20 April 2017

1 reference

Crystallizing membrane proteins using lipidic mesophases

20 April 2017

1 reference

Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

20 April 2017

1 reference

Differential expression of orexin receptors 1 and 2 in the rat brain

20 April 2017

1 reference

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

21 January 2018

1 reference

Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes

21 January 2018

1 reference

Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens

21 January 2018

1 reference

A role for lateral hypothalamic orexin neurons in reward seeking

21 January 2018

1 reference

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

21 January 2018

1 reference

Orexin-A, an hypothalamic peptide with analgesic properties

21 January 2018

1 reference

A key role for orexin in panic anxiety.

21 January 2018

1 reference

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

21 January 2018

1 reference

Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity

21 January 2018

1 reference

Crystallizing membrane proteins for structure determination: use of lipidic mesophases

21 January 2018

1 reference

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia

21 January 2018

1 reference

Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding

21 January 2018

1 reference

Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists

21 January 2018

1 reference

Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino

21 January 2018

1 reference

Scoring and lessons learned with the CSAR benchmark using an improved iterative knowledge-based scoring function

21 January 2018

1 reference

Comparative assessment of scoring functions on an updated benchmark: 2. Evaluation methods and general results

21 January 2018

1 reference

GPCRDB: an information system for G protein-coupled receptors

21 January 2018

1 reference

Structure-function of the G protein-coupled receptor superfamily

21 January 2018

1 reference

Update 1 of: Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders

21 January 2018

1 reference

Truncated Orexin Peptides: Structure-Activity Relationship Studies

21 January 2018

1 reference

Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation

21 January 2018

1 reference

Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2.

21 January 2018

1 reference

SEDPHAT--a platform for global ITC analysis and global multi-method analysis of molecular interactions.

21 January 2018

1 reference

Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor

21 January 2018

1 reference

Crystal structure of an archaeal glycogen synthase: insights into oligomerization and substrate binding of eukaryotic glycogen synthases

21 January 2018

1 reference

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

Fitting molecular fragments into electron density

21 January 2018

1 reference

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

21 January 2018

1 reference

FHL2 binds calcineurin and represses pathological cardiac growth

21 January 2018

1 reference

High-precision isothermal titration calorimetry with automated peak-shape analysis.

21 January 2018

1 reference

Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)

21 January 2018

1 reference

Mapping of the binding sites for the OX1 orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaeras

31 March 2020

1 reference

Xanthines as Adenosine Receptor Antagonists

31 March 2020

1 reference

Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring

31 March 2020

1 reference

Towards predictive docking at aminergic G-protein coupled receptors

31 March 2020

1 reference

Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26950369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Solution structure of human orexin-A: regulator of appetite and wakefulness

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26950369