(Q27824821)

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PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

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PubMed publication ID

13 November 2016

PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder (English)

1 reference

PubMed publication ID

13 November 2016

Martha Wadleigh

6

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Martha Wadleigh

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Martha

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Wadleigh

1 reference

PubMed publication ID

20 October 2023

author name string

Jing Chen

1

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Jing

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Chen

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PubMed publication ID

20 October 2023

Daniel J Deangelo

2

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Daniel J

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Deangelo

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20 October 2023

Jeffery L Kutok

3

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Jeffery L

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Kutok

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20 October 2023

Ifor R Williams

4

author given names

Ifor R

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Williams

1 reference

PubMed publication ID

20 October 2023

Benjamin H Lee

5

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Benjamin H

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Lee

1 reference

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20 October 2023

Nicole Duclos

7

author given names

Nicole

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Duclos

1 reference

PubMed publication ID

20 October 2023

Sarah Cohen

8

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Sarah

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Cohen

1 reference

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20 October 2023

Jennifer Adelsperger

9

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Jennifer

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Adelsperger

1 reference

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20 October 2023

Rachel Okabe

10

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Rachel

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Okabe

1 reference

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20 October 2023

Allison Coburn

11

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Allison

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Coburn

1 reference

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20 October 2023

Ilene Galinsky

12

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Ilene

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Galinsky

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20 October 2023

Brian Huntly

13

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Brian

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Huntly

1 reference

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20 October 2023

Pamela S Cohen

14

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Pamela S

author last names

Cohen

1 reference

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20 October 2023

Thomas Meyer

15

author given names

Thomas

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Meyer

1 reference

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20 October 2023

Doriano Fabbro

16

author given names

Doriano

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Fabbro

1 reference

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20 October 2023

Johannes Roesel

17

author given names

Johannes

author last names

Roesel

1 reference

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20 October 2023

Lolita Banerji

18

author given names

Lolita

author last names

Banerji

1 reference

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20 October 2023

James D Griffin

19

author given names

James D

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Griffin

1 reference

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20 October 2023

Sheng Xiao

20

author given names

Sheng

author last names

Xiao

1 reference

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20 October 2023

Jonathan A Fletcher

21

author given names

Jonathan A

author last names

Fletcher

1 reference

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20 October 2023

Richard M Stone

22

author given names

Richard M

author last names

Stone

1 reference

PubMed publication ID

20 October 2023

D Gary Gilliland

23

author given names

D Gary

author last names

Gilliland

1 reference

PubMed publication ID

20 October 2023

language of work or name

0 references

publication date

5 October 2004

0 references

Proceedings of the National Academy of Sciences of the United States of America

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101

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40

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14479-84

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8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

20 March 2017

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

7 April 2017

FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

29 September 2017

PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

29 September 2017

Imatinib alone and in combination for chronic myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

29 September 2017

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

29 September 2017

Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

29 September 2017

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

29 September 2017

A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

29 September 2017

A new myeloproliferative disorder associated with chromosomal translocations involving 8p11: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

29 September 2017

Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

29 September 2017

Aberrant expression of type I fibroblast growth factor receptor in human pancreatic adenocarcinomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

2 June 2018

Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

2 June 2018

Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521956

2 June 2018

Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3).

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404438101

21 January 2018

CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404438101

21 January 2018

Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404438101

21 January 2018

Phosphorylation of phospholipase C gamma 1 and its association with the FGF receptor is developmentally regulated and occurs during mesoderm induction in Xenopus laevis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15448205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKC412--a protein kinase inhibitor with a broad therapeutic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/15448205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.0404438101

0 references

2004PNAS..10114479C

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PMC publication ID

1 reference

PubMed publication ID

13 November 2016

PubMed publication ID

1 reference

PubMed publication ID

13 November 2016

ResearchGate publication ID

0 references

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