(Q28074931)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

review article

2 references

8 February 2021

Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

alternative mRNA splicing, via spliceosome

22 March 2020

main subject

1 reference

8 September 2019

1 reference

14 September 2020

1 reference

8 February 2021

Nancy Martínez-Montiel

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

Rebeca Martinez-Contreras

22 March 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

author name string

Nora Hilda Rosas-Murrieta

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Mónica Martínez-Montiel

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Mayra Patricia Gaspariano-Cholula

4

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

language of work or name

1 reference

16 August 2016

5 references

3 April 2019

8 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

14 September 2020

8 February 2021

BioMed Research International

6 references

3 April 2019

8 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

14 September 2020

8 February 2021

2016

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

page(s)

3681094

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

22 March 2020

copyright license

4 references

3 April 2019

8 September 2019

14 September 2020

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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1 reference

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Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

20 March 2017

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Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155

20 March 2017

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Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP

20 March 2017

1 reference

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The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo

20 March 2017

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

20 March 2017

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The spliceosome: design principles of a dynamic RNP machine

20 March 2017

1 reference

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Spliceosomal UsnRNP biogenesis, structure and function

20 March 2017

1 reference

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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

20 March 2017

1 reference

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Plants and phytochemicals for Huntington's disease

20 March 2017

1 reference

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Chemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plants

20 March 2017

1 reference

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Pre-mRNA splicing: awash in a sea of proteins

20 March 2017

1 reference

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Understanding alternative splicing: towards a cellular code

7 April 2017

1 reference

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Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.

7 April 2017

1 reference

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Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy

29 September 2017

1 reference

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Alternatively spliced isoforms of IL-32 differentially influence cell death pathways in cancer cell lines

29 September 2017

1 reference

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Herboxidiene biosynthesis, production, and structural modifications: prospect for hybrids with related polyketide

29 September 2017

1 reference

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Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

"Pruning of biomolecules and natural products (PBNP)": an innovative paradigm in drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Total synthesis of GEX1Q1, assignment of C-5 stereoconfiguration and evaluation of spliceosome inhibitory activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

High antitumor activity of pladienolide B and its derivative in gastric cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

SnapShot-Seq: a method for extracting genome-wide, in vivo mRNA dynamics from a single total RNA sample

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Hallmarks of alternative splicing in cancer

29 September 2017

1 reference

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Oncogenic alternative splicing switches: role in cancer progression and prospects for therapy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Aberrant alternative splicing is another hallmark of cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Enantioselective syntheses of FR901464 and spliceostatin A: potent inhibitors of spliceosome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Phase I pharmacokinetic and pharmacodynamic study of the first-in-class spliceosome inhibitor E7107 in patients with advanced solid tumors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

The spliceosome as a target of novel antitumour drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Role of splice variants in the metastatic progression of prostate cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Garbled messages and corrupted translations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Phytochemical investigation of Cycas circinalis and Cycas revoluta leaflets: moderately active antibacterial biflavonoids

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

The spliceosome as target for anticancer treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Alternative splicing and disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Increase in pladienolide D production rate using a Streptomyces strain overexpressing a cytochrome P450 gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

A synthetic entry to pladienolide B and FD-895

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Total synthesis of herboxidiene/GEX 1A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Molecular anatomy of a speckle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Multiple U2AF65 binding sites within SF3b155: thermodynamic and spectroscopic characterization of protein-protein interactions among pre-mRNA splicing factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Biflavones from Chamaecyparis obtusa.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

2 June 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

Biflavone glucosides from Ginkgo biloba yellow leaves

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

Effect of biflavones of Ginkgo biloba against UVB-induced cytotoxicity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

Neuroprotective effects of naturally occurring biflavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

Human Telomerase RNA Processing and Quality Control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

CRISPR/Cas9-mediated target validation of the splicing inhibitor Pladienolide B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3681094

GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. I. Taxonomy, production, isolation, physicochemical properties and biological activities

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Isolation and characterization of a new 12-membered macrolide FD-895

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004037

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation

27 November 2018

1 reference

12 December 2020

Natural inhibitors targeting osteoclast-mediated bone resorption

1 reference

12 December 2020

Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression

1 reference

12 December 2020

Total synthesis of the potent antitumor macrolides pladienolide B and D

1 reference

12 December 2020

Total synthesis of GEX1A

1 reference

12 December 2020

Inhibition of arachidonate release from rat peritoneal macrophage by biflavonoids

1 reference

12 December 2020

Biflavonoids from Caper (Capparis spinosa L.) fruits and their effects in inhibiting NF-kappa B activation

1 reference

12 December 2020

Total synthesis of (+)-herboxidiene from two chiral lactate-derived ketones

1 reference

12 December 2020

SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications

1 reference

12 December 2020

Comparison of splicing factor 3b inhibitors in human cells

1 reference

12 December 2020

Enantioselective synthesis of pladienolide B and truncated analogues as new anticancer agents

1 reference

12 December 2020

[Alternative splicing regulation: implications in cancer diagnosis and treatment]

1 reference

12 December 2020

Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids

1 reference

12 December 2020

Separation of splicing factor SF3 into two components and purification of SF3a activity

1 reference

12 December 2020

New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action

1 reference

12 December 2020

Trichostatin A and herboxidiene up-regulate the gene expression of low density lipoprotein receptor

1 reference

12 December 2020

Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue

1 reference

12 December 2020

GEX1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. I. Taxonomy, Production, Isolation, Physicochemical Properties and Biological Activities.

1 reference

COCI

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.55.855

12 April 2024

Identifiers

DOI

10.1155/2016/3681094

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610372%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

2 references