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Recent advances in T-cell engineering for use in immunotherapy
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scholarly article
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PubMed
review article
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Europe PubMed Central
title
Recent advances in T-cell engineering for use in immunotherapy
(English)
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stated in
PubMed
main subject
immunotherapy
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based on heuristic
inferred from title
author name string
Preeti Sharma
series ordinal
1
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Crossref
David M. Kranz
series ordinal
2
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
19 September 2016
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stated in
PubMed
published in
F1000Research
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Crossref
volume
5
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stated in
PubMed
copyright license
Creative Commons Attribution 4.0 International
start time
19 September 2016
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stated in
April 2022 Public Data File from Crossref
copyright status
copyrighted
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High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
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29 September 2017
Target antigen density governs the efficacy of anti-CD20-CD28-CD3 ζ chimeric antigen receptor-modified effector CD8+ T cells
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T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
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Insights into the initiation of TCR signaling
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A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control
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RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer
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29 September 2017
Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.
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29 September 2017
Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells
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Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
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29 September 2017
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
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29 September 2017
Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
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29 September 2017
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29 September 2017
Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients
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29 September 2017
SHP-1 phosphatase activity counteracts increased T cell receptor affinity
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29 September 2017
Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
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Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategies
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29 September 2017
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
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29 September 2017
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Attenuated T cell responses to a high-potency ligand in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Functional development of the T cell receptor for antigen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
The impact of TCR-binding properties and antigen presentation format on T cell responsiveness
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Genetically engineered T cells to target EGFRvIII expressing glioblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Facilitating matched pairing and expression of TCR chains introduced into human T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
A mutant chaperone converts a wild-type protein into a tumor-specific antigen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Dynamics of Cell Surface Molecules During T Cell Recognition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
TCRs with high affinity for foreign pMHC show self-reactivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Positive and negative selection of T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
29 September 2017
Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
2 June 2018
Functional comparison of engineered T cells carrying a native TCR versus TCR-like antibody-based chimeric antigen receptors indicates affinity/avidity thresholds
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
2 June 2018
A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
2 June 2018
Complete but curtailed T-cell response to very low-affinity antigen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
2 June 2018
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
2 June 2018
Serial triggering of many T-cell receptors by a few peptide-MHC complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
2 June 2018
Chimeric antigen receptor T cells for cancer immunotherapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
The first structures of T cell receptors bound to peptide-MHC.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
T cell killing does not require the formation of a stable mature immunological synapse.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
Stable, soluble T-cell receptor molecules for crystallization and therapeutics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
Direct observation of ligand recognition by T cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
T cell activation by recombinant FcepsilonRI gamma-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5031132
retrieved
27 November 2018
Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27703664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27703664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27703664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Molecular design of the Calphabeta interface favors specific pairing of introduced TCRalphabeta in human T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27703664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.12688/F1000RESEARCH.9073.1
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3461955
OpenCitations bibliographic resource ID
3461955
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3461955
PMC publication ID
5031132
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3461955
PubMed publication ID
27703664
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3461955
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