(Q38541019)

PubMed publication ID

3 September 2017

1 reference

title

The pharmacology of second-generation chimeric antigen receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

13 May 2020

1 reference

Sjoukje J C van der Stegen

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

13 May 2020

Mohamad Hamieh

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

13 May 2020

Michel Sadelain

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

13 May 2020

publication date

1 July 2015

1 reference

PubMed publication ID

26129802

Nature Reviews Drug Discovery

3 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

13 May 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

13 May 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

13 May 2020

page(s)

499-509

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

Targeting tumours with genetically enhanced T lymphocytes

13 May 2020

cites work

1 reference

Adoptive immunotherapy: engineering T cell responses as biologic weapons for tumor mass destruction

31 March 2020

1 reference

Cancer regression in patients after transfer of genetically engineered lymphocytes

31 March 2020

1 reference

Adoptive immunotherapy of disseminated leukemia with TCR-transduced, CD8+ T cells expressing a known endogenous TCR.

31 March 2020

1 reference

The promise and potential pitfalls of chimeric antigen receptors

31 March 2020

1 reference

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

31 March 2020

1 reference

CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

31 March 2020

1 reference

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

31 March 2020

1 reference

Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia

31 March 2020

1 reference

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

31 March 2020

1 reference

Chimeric antigen receptor T cells for sustained remissions in leukemia

31 March 2020

1 reference

Chimeric Antigen Receptor Therapy for B-cell Malignancies

31 March 2020

1 reference

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

31 March 2020

1 reference

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

31 March 2020

1 reference

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

31 March 2020

1 reference

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

31 March 2020

1 reference

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia.

31 March 2020

1 reference

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

31 March 2020

1 reference

Transfer of specificity by murine alpha and beta T-cell receptor genes

31 March 2020

1 reference

An enigmatic tail of CD28 signaling

31 March 2020

1 reference

Molecular cloning of the zeta chain of the T cell antigen receptor

31 March 2020

1 reference

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

31 March 2020

1 reference

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

31 March 2020

1 reference

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.

31 March 2020

1 reference

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors

31 March 2020

1 reference

New simplified molecular design for functional T cell receptor

31 March 2020

1 reference

Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes

31 March 2020

1 reference

Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen

31 March 2020

1 reference

Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes

31 March 2020

1 reference

Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule

31 March 2020

1 reference

Differential T cell costimulatory requirements in CD28-deficient mice

31 March 2020

1 reference

Molecular mechanisms of T cell co-stimulation and co-inhibition

31 March 2020

1 reference

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

31 March 2020

1 reference

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

31 March 2020

1 reference

A new member of the immunoglobulin superfamily--CTLA-4

31 March 2020

1 reference

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

31 March 2020

2 references

31 March 2020

12 December 2020

Monoclonal antibody 9.3 and anti-CD11 antibodies define reciprocal subsets of lymphocytes

1 reference

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

31 March 2020

1 reference

Immunobiology of CD28 expression on human neutrophils. I. CD28 regulates neutrophil migration by modulating CXCR-1 expression

31 March 2020

1 reference

Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway

31 March 2020

1 reference

T cell activation determined by T cell receptor number and tunable thresholds.

31 March 2020

1 reference

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

31 March 2020

1 reference

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

31 March 2020

1 reference

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

31 March 2020

1 reference

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

31 March 2020

1 reference

Signals from CD28 induce stable epigenetic modification of the IL-2 promoter

31 March 2020

1 reference

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

31 March 2020

1 reference

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming

31 March 2020

1 reference

Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by

31 March 2020

1 reference

c-Rel is required for chromatin remodeling across the IL-2 gene promoter

31 March 2020

1 reference

A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory

31 March 2020

1 reference

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

31 March 2020

1 reference

Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

31 March 2020

1 reference

The CD28 signaling pathway regulates glucose metabolism

31 March 2020

1 reference

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

31 March 2020

1 reference

IL-7 enhances the survival and maintains the size of naive T cells

31 March 2020

1 reference

Growth factors can influence cell growth and survival through effects on glucose metabolism

31 March 2020

1 reference

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

31 March 2020

1 reference

CD28-mediated co-stimulation: a quantitative support for TCR signalling

31 March 2020

1 reference

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

31 March 2020

1 reference

The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression

31 March 2020

1 reference

Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells.

31 March 2020

1 reference

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation

31 March 2020

1 reference

Induction, binding specificity and function of human ICOS

31 March 2020

1 reference

CD28 co-stimulation stabilizes the expression of the CD40 ligand on T cells

31 March 2020

1 reference

NF-kappaB and AP-1 regulate activation-dependent CD137 (4-1BB) expression in T cells

31 March 2020

1 reference

Memory CD8+ T cells require CD28 costimulation.

31 March 2020

1 reference

Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response

31 March 2020

1 reference

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function

31 March 2020

1 reference

Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes

31 March 2020

1 reference

Differential down-regulation of CD28 by B7-1 and B7-2 engagement

31 March 2020

1 reference

Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription

31 March 2020

1 reference

Regulation of CD28 expression on CD8+ T cells by CTLA-4

31 March 2020

1 reference

4-1BBL costimulation retrieves CD28 expression in activated T cells

31 March 2020

1 reference

Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production

31 March 2020

1 reference

Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.

31 March 2020

1 reference

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

31 March 2020

1 reference

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

31 March 2020

1 reference

Restoring function in exhausted CD8 T cells during chronic viral infection

31 March 2020

1 reference

PD-1 signaling in primary T cells

31 March 2020

1 reference

Costimulation of T cells by OX40, 4-1BB, and CD27.

31 March 2020

1 reference

Isolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones

31 March 2020

1 reference

cDNA sequences of two inducible T-cell genes

31 March 2020

1 reference

A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family

31 March 2020

1 reference

4-1BB signal stimulates the activation, expansion, and effector functions of γδ T cells in mice and humans.

31 March 2020

1 reference

NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies.

31 March 2020

1 reference

CD137 promotes proliferation and survival of human B cells

31 March 2020

1 reference

Cutting edge: Expression of functional CD137 receptor by dendritic cells

31 March 2020

1 reference

CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity.

31 March 2020

1 reference

Differentiation-dependent and stimulus-specific expression of ILA, the human 4-1BB-homologue, in cells of mesenchymal origin

31 March 2020

1 reference

Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells

31 March 2020

1 reference

Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor

31 March 2020

1 reference

4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells

31 March 2020

1 reference

Molecular and biological characterization of human 4-1BB and its ligand

31 March 2020

1 reference

CD137 ligand prevents the development of T-helper type 2 cell-mediated allergic asthma by interferon-gamma-producing CD8+ T cells

31 March 2020

1 reference

The Structure of the Trimer of Human 4-1BB Ligand Is Unique among Members of the Tumor Necrosis Factor Superfamily

31 March 2020

1 reference

Dual immunoregulatory pathways of 4-1BB signaling

31 March 2020

1 reference

Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo

31 March 2020

1 reference

Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses.

31 March 2020

1 reference

IL-15-dependent induction of 4-1BB promotes antigen-independent CD8 memory T cell survival.

31 March 2020

1 reference

Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes

31 March 2020

1 reference

4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy

31 March 2020

1 reference

4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function

31 March 2020

1 reference

Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B

31 March 2020

1 reference

4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

31 March 2020

1 reference

CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand

31 March 2020

1 reference

Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

31 March 2020

1 reference

ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo

31 March 2020

1 reference

Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells

31 March 2020

1 reference

Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response

31 March 2020

1 reference

TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs

31 March 2020

1 reference

4-1BB enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1.

31 March 2020

1 reference

Costimulation of human CD28- T cells by 4-1BB ligand

31 March 2020

1 reference

Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging.

31 March 2020

1 reference

During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion

31 March 2020

1 reference

4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses

31 March 2020

1 reference

TNF family ligands define niches for T cell memory.

31 March 2020

1 reference

Immune responses in 4-1BB (CD137)-deficient mice

31 March 2020

1 reference

TNF/TNFR family members in costimulation of T cell responses

31 March 2020

1 reference

Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells

31 March 2020

1 reference

Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection

31 March 2020

1 reference

Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells

31 March 2020

1 reference

Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death

31 March 2020

1 reference

Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins.

31 March 2020

1 reference

Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes

31 March 2020

1 reference

Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts

31 March 2020

1 reference

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

31 March 2020

1 reference

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

31 March 2020

1 reference

4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies

31 March 2020

1 reference

Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication

31 March 2020

1 reference

CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo

31 March 2020

1 reference

T cells bearing a chimeric antigen receptor against prostate-specific membrane antigen mediate vascular disruption and result in tumor regression.

31 March 2020

1 reference

Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain

31 March 2020

1 reference

ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

31 March 2020

1 reference

Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling

31 March 2020

1 reference

IL-2: the first effective immunotherapy for human cancer.

31 March 2020

1 reference

Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells

31 March 2020

1 reference

CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation

31 March 2020

1 reference

Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

31 March 2020

1 reference

T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms.

31 March 2020

1 reference

Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells

31 March 2020

1 reference

BRAF and MEK inhibition variably affect GD2-specific chimeric antigen receptor (CAR) T-cell function in vitro

31 March 2020

1 reference

In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)

31 March 2020

1 reference

Sequence, structure, function, immunity: structural genomics of costimulation.

31 March 2020

1 reference

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

31 March 2020

1 reference

Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model.

31 March 2020

1 reference

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.

31 March 2020

1 reference

CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia.

31 March 2020

1 reference

Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity

31 March 2020

1 reference

IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers

31 March 2020

1 reference

T-helper-1-cell cytokines drive cancer into senescence

31 March 2020

1 reference

Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFNγ-dependent cell-cycle arrest.

31 March 2020

1 reference

CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.

31 March 2020

1 reference

The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation.

31 March 2020

1 reference

Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells

31 March 2020

1 reference

Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

31 March 2020

1 reference

PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

31 March 2020

1 reference

Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.

31 March 2020

1 reference

Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy

31 March 2020

1 reference

Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition

31 March 2020

1 reference

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver

31 March 2020

1 reference

Identification of the earliest B lineage stage in mouse bone marrow

31 March 2020

1 reference

T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect

31 March 2020

1 reference

CARs on track in the clinic

31 March 2020

1 reference

Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans

31 March 2020

1 reference

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

31 March 2020

1 reference

CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

31 March 2020

1 reference

Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

31 March 2020

1 reference

Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

31 March 2020

1 reference

Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy

31 March 2020

1 reference

Current concepts in the diagnosis and management of cytokine release syndrome

31 March 2020

1 reference

How do CARs work?: Early insights from recent clinical studies targeting CD19.

31 March 2020

1 reference

The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.

31 March 2020

1 reference

Bcl-6 directly represses the gene program of the glycolysis pathway

31 March 2020

1 reference

ICOS co-stimulatory receptor is essential for T-cell activation and function

31 March 2020

1 reference

ICOS is essential for effective T-helper-cell responses

31 March 2020

1 reference

ICOS controls the pool size of effector-memory and regulatory T cells.

31 March 2020

1 reference

Chimeric antigen receptor containing ICOS signaling domain mediates specific and efficient antitumor effect of T cells against EGFRvIII expressing glioma

31 March 2020

1 reference

OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection

31 March 2020

1 reference

OX40 drives protective vaccinia virus-specific CD8 T cells

31 March 2020

1 reference

The role of TNF superfamily members in T-cell function and diseases

31 March 2020

1 reference

Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

31 March 2020

1 reference

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

31 March 2020

1 reference

Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor

31 March 2020

1 reference

CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation.

31 March 2020

1 reference

The Pim kinases control rapamycin-resistant T cell survival and activation

31 March 2020

1 reference

Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology

31 March 2020

1 reference

NKG2D CARs as cell therapy for cancer

31 March 2020

1 reference

A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells

31 March 2020

1 reference

Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection

31 March 2020

1 reference

Chimeric NKG2D CAR-expressing T cell-mediated attack of human ovarian cancer is enhanced by histone deacetylase inhibition

31 March 2020

1 reference

Chimeric NKG2D T cells require both T cell- and host-derived cytokine secretion and perforin expression to increase tumor antigen presentation and systemic immunity

31 March 2020

1 reference

Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells.

31 March 2020

1 reference

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

31 March 2020

1 reference

Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains

31 March 2020

1 reference

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

31 March 2020

1 reference

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

31 March 2020

1 reference

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

31 March 2020

1 reference

Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling.

31 March 2020

1 reference

Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo

31 March 2020

1 reference

Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells

31 March 2020

1 reference

The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

31 March 2020

1 reference

Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane.

31 March 2020

1 reference

The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens

31 March 2020

1 reference

Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model

31 March 2020

1 reference

The optimal antigen response of chimeric antigen receptors harboring the CD3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogenous TCR/CD3 complex.

31 March 2020

1 reference

The journey from discoveries in fundamental immunology to cancer immunotherapy

31 March 2020

1 reference

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

31 March 2020

1 reference

Agonist antibodies to TNFR molecules that costimulate T and NK cells

31 March 2020

1 reference

Advances in targeting cell surface signalling molecules for immune modulation

31 March 2020

1 reference

Mitigating the toxic effects of anticancer immunotherapy

31 March 2020

1 reference

OX40 is a potent immune-stimulating target in late-stage cancer patients

31 March 2020

1 reference

A phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors

31 March 2020

1 reference

A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma

31 March 2020

1 reference

A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia.

31 March 2020

1 reference

Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma

31 March 2020

1 reference

Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab

31 March 2020

1 reference

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

31 March 2020

1 reference

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

31 March 2020

1 reference

Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial

31 March 2020

1 reference

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

31 March 2020

1 reference

CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes

31 March 2020

1 reference

12 December 2020

Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal

1 reference

12 December 2020

Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus.

1 reference

12 December 2020

Chimeric Fv-zeta or Fv-epsilon receptors are not sufficient to induce activation or cytokine production in peripheral T cells

1 reference

12 December 2020

Human eosinophils express and release IL-13 following CD28-dependent activation

1 reference

12 December 2020

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody

1 reference

12 December 2020

The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression

1 reference

12 December 2020

The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation

1 reference

12 December 2020

Enhanced antitumor activity mediated by human 4-1BB-engineered T cells

1 reference

12 December 2020

Metabolism of activated T lymphocytes.

1 reference

12 December 2020

Changes in lymphocytes' telomerase activity by 4-1BB costimulation

1 reference

12 December 2020

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system

1 reference

12 December 2020

Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells.

1 reference

12 December 2020

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1 reference

12 December 2020

Inducible T cell antigen 4-1BB. Analysis of expression and function

1 reference

12 December 2020

ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages

1 reference

12 December 2020

CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response

1 reference

12 December 2020

Costimulation of CD28- T lymphocytes by 4-1BB ligand

1 reference

12 December 2020

Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells

1 reference

12 December 2020

Recombinant retroviruses pseudotyped with the vesicular stomatitis virus G glycoprotein mediate both stable gene transfer and pseudotransduction in human peripheral blood lymphocytes

1 reference

12 December 2020

Harnessing Syk family tyrosine kinases as signaling domains for chimeric single chain of the variable domain receptors: optimal design for T cell activation

1 reference

12 December 2020

Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product

1 reference

12 December 2020

Qualitative and quantitative effects of CD28/B7-mediated costimulation on naive T cells in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4597

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

release_6x24ukzzebe3xmge7fe5vuxnjq

13 May 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6x24ukzzebe3xmge7fe5vuxnjq

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json

13 May 2020

PubMed publication ID

26129802

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410718&resulttype=core&format=json